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Circulating Chymase and Chronic Kidney Disease: An Analysis of Current Treatments, Demographics, and Clinical Risk Factors

JSHS · 2024

Vaishnavi Kumbala, Dr. Jing Chen · Haynes Academy for Advanced Studies, Metairie, LA

Overview

Chronic kidney disease (CKD) results in a progressive loss of kidney function over time, affecting 37 million in the US. Chymase is the primary enzyme mediating angiotensin II formation independent of the angiotensin-converting enzyme, potentially causing renal fibrosis. This novel study investigated differences in chymase levels between CKD -affected populations and non -CKD-affected populations while adjusting for potential confounding of current treatment, clinical risk factors, and medical history. Popul ation was organized into two groups in New Orleans: participants diagnosed with CKD (n=163) and the control group, participants not diagnosed with CKD (n=186). Three models were created to measure differences in median chymase levels between the two groups while adjusting for common CKD risk factors and treatments. Medians and interquartile ranges for plasma chymase were calculated for both groups, and Mann-Whitney Utests determined differences in the unadjusted medians. Quantile regression was used to create the three models and obtain multivariable-adjusted medians for plasma chymase levels in both groups. Wald tests assessed differences in adjusted medians between the two groups for all three models. After adjustment for all variables tested, median plas ma chymase remained significantly higher (p=0.04) in CKD patients (1.7 pg/mL) compared to controls (1.2 pg/mL). This study established an association between elevated chymase levels and CKD, independent of all factors studied. Results provide the foundation for vital further research determining if chymase is a viable measure to predict CKD progression and assessing effectiveness of chymase inhibitors in improving renal outcomes for CKD patients.

Competition history

  • JSHS 2024 Category not listed

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