Browse real student projects, abstracts, and awards.
ISEF · 2025
Earth and Environmental Sciences
Mycorrhizal fungi establish underground networks that form symbiotic relationships with almost all plant species and facilitate crucial ecological processes, but habitat degradation is their…
ISEF · 2025
Cellular and Molecular Biology
Genetics is an ever-expanding field of research. The genetic field has rapidly expanded from Mendel’s studies to genetically modified treatments, multi-allele variation knowledge, and studie…
ISEF · 2025
Robotics and Intelligent Machines
Nearly 1 in 8 people in the U.S. suffer from movement disorders, significantly impacting their quality of life. Neuromuscular disabilities cost the healthcare system $420 billion annually. D…
ISEF · 2025
Technology Enhances the Arts
Over 2.1 million people in the United States live with limb loss, with approximately 185,000 amputations occurring annually. Limb differences often pose challenges in using input devices suc…
ISEF · 2025
Chemistry
This research, conducted during a paid summer internship through ACS Project SEED, focused on synthesizing and analyzing N-3-HPA for their potential use in seizure management. To develop eff…
ISEF · 2025
Microbiology
Oral mucositis is an inflammation that causes pain and ulcers that affect cancer patients undergoing radiotherapy and/or chemotherapy. The condition is marked by oral mucosa inflammation, wh…
ISEF · 2025
Biomedical and Health Sciences
Helicobacter pylori is a bacterial strain that attaches to gastric mucosal cells through its BabA adhesin, which begins growth of colonies that increase risk of peptic ulcers and gastric or…
ISEF · 2025
Biochemistry
Amyloid-ß (Aß) extracellular plaques in the brain are a primary cause of Alzheimer’s Disease. Previous studies have focused on understanding cerebral Aß production and prevention. However, n…
ISEF · 2025
Earth and Environmental Sciences
Coastal erosion costs around $500 million per year due to damages to essential infrastructure (NOAA, 2025). Scientists have explored nature-based solutions to coastal erosion, specifically t…
ISEF · 2025
Robotics and Intelligent Machines
The most sought-after goal in machine learning is achieving artificial general intelligence, which requires stable memory and flexibility in learning. Existing models are dependent on all da…
ISEF · 2025
Physics and Astronomy
Traditional exoplanet detection methods often overlook multi-planet systems containing long-period or non-transiting planets due to observational biases favoring short-period transiting plan…
ISEF · 2025
Behavioral and Social Sciences
Animals can engage in lifelong learning because they can form, consolidate, and recall memories. Because sleep plays a vital role in consolidating newly acquired information and aiding recal…
ISEF · 2025
Embedded Systems
Chronic stress can severely impact mental and physical health, contributing to conditions like anxiety, depression, and cardiovascular issues. Inspired by an ancient Buddhist mindfulness bre…
ISEF · 2025
Biomedical Engineering
Current lower limb prostheses rely on cumbersome procedures, need risky surgery, and are prohibitively expensive. As a result, many lower-limb amputees experience unnatural gait patterns and…
ISEF · 2025
Computational Biology and Bioinformatics
Accurate classification of brain tumors is essential for effective patient treatment. In recent years, artificial intelligence has shown significant promise in improving medical diagnostics.…
ISEF · 2025
Biomedical Engineering
Neuroprosthetics offer more advanced functionality compared to traditional prosthetics, but their high cost and invasive procedures limit accessibility. This research focuses on developing a…
ISEF · 2025
Translational Medical Science
CTE, a progressive neurodegenerative condition from repetitive head impacts in sports, lacks preventive interventions. This research examines curcumin and CoQ10's neuroprotective effects in…
ISEF · 2025
Biomedical and Health Sciences
The therapeutic value of traditional plants in the Philippines remains underexplored. Thus, this study investigates the neuroprotective potential of Premna odorata leaf extract for Alzheimer…
ISEF · 2025
Cellular and Molecular Biology
Current underlying mechanisms to treat neurodegenerative diseases (ND) are limited due to an incomplete understanding. Tight junctions (TJ) and efflux pumps on the BBB restrict drug permeabi…
ISEF · 2025
Biomedical Engineering
Neurodegenerative diseases (NDDs), conditions characterized by damaged cell networks in the neurological system, are becoming increasingly prevalent as the global life-expectancy continually…
ISEF · 2025
Earth and Environmental Sciences
This study describes a novel species of snail in the genus Japonia (subfamily Cyclophoridae, family Cyclophoridae) discovered in Hong Kong. This species is distinguished by unique long, spoo…
ISEF · 2025
Physics and Astronomy
The possible existence of sub-solar mass black holes poses a challenge to current models of stellar evolution, as there is no known formation mechanism to produce such objects. There is some…
ISEF · 2025
Translational Medical Science
The widespread use of drugs, together with their limited specificity and poor biodistribution, poses significant challenges. Antibiotic resistance, aggravated by decades of uncontrolled cons…
ISEF · 2025
Physics and Astronomy
Simply expressed, antibubbles are the material opposite of soap bubbles. They consist internally of a virtually spherical volume of fluid that is separated from the surrounding fluid, typica…
ISEF · 2025
Environmental Engineering
Water pollution is a pressing global issue, exacerbated by inefficient wastewater treatment technologies that fail to remove emerging contaminants such as pharmaceuticals, antibiotics, and a…
ISEF · 2025
Engineering Technology: Statics & Dynamics
Drones are widely used in military and civilian applications, with VTOL (Vertical Takeoff and Landing) drones combining the vertical lift capability of helicopters with the horizontal cruisi…
ISEF · 2025
Materials Science
Smart, thermo-responsive polymeric gel compositions were developed using alginate-p-NIPAM (poly-N-isopropylacrylamide) and biocompatible conductive segments. These waterborne formulations we…
ISEF · 2025
Earth and Environmental Sciences
Lake-effect precipitation, which significantly impacts regions downwind of the Great Lakes, poses unique forecasting challenges due to its dependence on localized processes and intricate int…
ISEF · 2025
Animal Sciences
Hot Springs National Park (HOSP) has had two inventories of its amphibians and reptiles in the last 20 years. Despite limited results, they remain the most conclusive research of HOSP’s herp…
ISEF · 2025
Behavioral and Social Sciences
This study introduces an innovative intervention using sleep wave simulation therapy to treat panic attacks. Panic disorder is a disabling condition characterized by recurrent, unexpected pa…