Browse real student projects, abstracts, and awards.
ISEF · 2025
Microbiology
Francisella tularensis, a gram-negative bacterium, is the causative agent of tularemia, a severe zoonotic disease. The CDC classifies F. tularensis as a tier one biothreat agent, as it is hi…
ISEF · 2025
Microbiology
Cutavirus (CuV) belongs to the genus Protoparvovirus, which includes important viruses such as H-1PV, MVMp, and LuIII, known for their applications in cancer therapies and as gene therapy ve…
ISEF · 2025
Plant Sciences
Downy brome (Bromus tectorum) is an invasive annual, cool-season grass that invades disturbed land impacted by overgrazing, fire, drought, and road construction. The application of weed supp…
ISEF · 2025
Materials Science
Biomedical devices for personalized health monitoring are crucial for early disease detection and therapy, yet current devices are rigid and uncomfortable, causing issues with long-term wear…
ISEF · 2025
Computational Biology and Bioinformatics
Obesity-driven inflammation is primarily caused by pro-inflammatory immune cell infiltration, which leads to an increased secretion of pro-inflammatory cytokines like TNF and IL-6. This driv…
ISEF · 2025
Animal Sciences
The circadian rhythm is a 24-hour biological clock that regulates physiological and behavioral cycles in response to environmental light cues. While previous studies on circadian rhythms in…
ISEF · 2025
Biomedical Engineering
The ClearSight project aims to reduce myopia progression through targeted eye exercises that strengthen eye muscles. Myopia, or blurred distance vision, is rising globally due to genetic and…
ISEF · 2025
Behavioral and Social Sciences
The brain doesn’t always age at the same pace as the rest of the body. Some people's brains stay sharp well into old age, while others show signs of decline decades earlier. Detecting these…
ISEF · 2025
Microbiology
Bacteriophages are viruses that infect bacteria. During infection a phage attaches to a bacterium and proceeds to insert its genetic material into the cell. After that the phage follows one…
ISEF · 2025
Engineering Technology: Statics & Dynamics
The objective of the research was to design an automated mechanical clothesline system equipped with a rain sensor. This development provided an efficient solution for people who dry their c…
ISEF · 2025
Technology Enhances the Arts
Natural Language Processing has led to the development of voice recognition technology, and taking speech analysis further can lead to the development of technology to aid in treatment of sp…
ISEF · 2025
Animal Sciences
Stingless bees (Tetragonula (Tetragonilla) collina) are key pollinators in agriculture and ecosystems. However, they are at risk of extinction due to the rapid urbanization, unsustainable ha…
ISEF · 2025
Translational Medical Science
Colorectal cancer is the second leading cause of cancer-related deaths, and early detection is critical. However, traditional pathology is time-consuming, expensive, and dependent on subject…
ISEF · 2025
Technology Enhances the Arts
This project explores a color-to-haptic feedback system designed to assist individuals with visual impairments in perceiving color through touch. A wearable glove equipped with a Red, Blue,…
ISEF · 2025
Microbiology
Chronic inflammation is a significant health concern, damaging tissues and cells, leading to serious diseases like cancer, heart disease, and diabetes. Many anti-inflammatory treatments, suc…
ISEF · 2025
Plant Sciences
Meloidogyne spp., or the root-knot nematode, is the most destructive nematode disease worldwide and persists in threatening the sustainability of the vegetable industry in numerous regions.…
ISEF · 2025
Microbiology
Staphylococcus aureus is a gram-positive pathogenic bacteria that causes community-onset and nosocomial infections, making it a global healthcare threat. Its ability to evade host responses…
ISEF · 2025
Mathematics
This study delves into the computation and classification of combinatorial invariants associated with stable curves in genus 4. The work builds upon Zhang's decomposition formula, emphasizin…
ISEF · 2025
Translational Medical Science
Oral cancer kills over 300,000 lives across the world every year, and oral squamous cell carcinoma (OSCC) is a dominant type of oral cancer. Current diagnosis steps for OSCC typically involv…
ISEF · 2025
Plant Sciences
The parasitic plant, Striga hermonthica, threatens food security in Africa and affects the income of smallholder farmers, with impacts between $7-10 billion USD annually. A newly emerging st…
ISEF · 2025
Biomedical and Health Sciences
Chimeric Antigen Receptor (CAR) T Cells and Bispecific T Cell Engagers (BiTEs) have revolutionized the treatment of relapsed/refractory hematologic cancers. However, there are no head-to-hea…
ISEF · 2025
Energy: Sustainable Materials and Design
First-generation biofuel crops, like corn and peanuts, are effective for biodiesel production, but compete with food crops and require arable land use. Third-generation biofuels, such as bee…
ISEF · 2025
Translational Medical Science
Psoriasis is a chronic immune-mediated inflammatory disorder affecting over 125 million individuals worldwide, characterized by keratinocyte hyperproliferation and dysregulated inflammatory…
ISEF · 2025
Chemistry
Antibiotic-resistant bacteria cause over 2 million infections annually in the US, driving the need for new antimicrobials. Zinc oxide nanoparticles (ZnONPs) are a promising solution, but con…
ISEF · 2025
Plant Sciences
Sallyqueen is a rice variety derived from a Nipponbare × BASMATI370 cross. Its grain length and width are approximately 1.15 and 0.73 times that of Nipponbare, respectively. Some grains were…
ISEF · 2025
Energy: Sustainable Materials and Design
This science fair project is about Peltier Tiles and Piezoelectric Harvesters and determining which renewable energy source serves as a better source of electricity and applications for both…
ISEF · 2025
Robotics and Intelligent Machines
The citrus industry in Florida has been devastated with multiple diseases - greening, canker, and blackspot - leading to tree death, orchard closure, and lost orange production. Traditional…
ISEF · 2025
Microbiology
Tardigrades are one of the many organisms that have the capability of surviving extreme environments. They do this by going into a stasis known as cryptobiosis including the lack of water kn…
ISEF · 2025
Earth and Environmental Sciences
This project investigated the correlation between solar indices (AE, By, Bz, SYM_H, and F10.7), aurora activity, and TIMt layers. This research was motivated by the findings of Chu et al. 20…
ISEF · 2025
Computational Biology and Bioinformatics
Competitive target-mediated drug disposition (competitive TMDD) has been used to describe the behavior of two different types of ligands competing for a common receptor. Due to the complexit…