Browse real student projects, abstracts, and awards.
ISEF · 2026
Translational Medical Science
Can neuron resilience be predicted as topological failure of cellular identity? Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by TDP-43 aggregation and moto…
ISEF · 2026
Engineering Technology: Statics & Dynamics
Traditional forest fire monitoring suffers from inherent flaws, including early warning lag, safety risks of manual sensor deployment in complex terrain, limited flight endurance of conventi…
ISEF · 2026
Environmental Engineering
Mitigating climate change requires carbon dioxide removal, but conventional Direct Air Capture is prohibitively expensive. A scalable alternative is distributed, passive capture: embedding C…
ISEF · 2026
Animal Sciences
Black soldier fly larvae (BSFL) are increasingly recognized as a promising alternative protein source that can help address solid waste issues amid rapid global population growth. However, h…
ISEF · 2026
Energy: Sustainable Materials and Design
Due to population growth and technological advancement, global energy demand is on the rise. Yet 86% of the world's energy is from burning fossil fuels, with only 8% from sustainable methods…
ISEF · 2026
Translational Medical Science
Dementia affects 55 million people globally, projected to reach 139 million by 2050. Although deep learning models achieve 90–98% accuracy for dementia classification, clinical adoption is h…
ISEF · 2026
Computational Biology and Bioinformatics
XenoFold is a chemistry-conditioned generative framework designed to computationally propose enzymes capable of degrading xenobiotic pollutants. The system integrates reaction-aware molecula…
ISEF · 2026
Computational Biology and Bioinformatics
With over 1.8 million deaths from lung cancer annually, it is imperative to develop immunotherapies that precisely target these tumors while minimizing off-target effects on healthy cells. A…
ISEF · 2026
Computational Biology and Bioinformatics
Genetically complex multisystem disorders (CMDs) affecting neonatal populations arise from coordinated regulatory interactions across genes, tissues, and organ systems, yet their underlying…
ISEF · 2026
Engineering Technology: Statics & Dynamics
When disaster strikes, the difference between life and death often comes down to timely information. First responders need an aerial view immediately, but current drones capable of both vert…
ISEF · 2026
Energy: Sustainable Materials and Design
Hydrogen has emerged as a promising green energy storage solution due to its on-demand energy release through fuel cells. However, major barriers to wide-scale adoption remain: inefficiency…
ISEF · 2026
Plant Sciences
The fall armyworm is a destructive pest affecting more than 80 plant species, most notably maize, resulting in an estimated $9.4 billion in annual agricultural losses. As the global populati…
ISEF · 2026
Materials Science
Various factors, such as inflation, tariffs, deforestation, disease, and increasing manufacturing costs, have led to scarcity and high material costs in recent years. Annually, billions of p…
ISEF · 2026
Animal Sciences
Anti-apoptotic B-cell leukemia/lymphoma (Bcl-2) proteins are overexpressed in around half of human cancers, linked to tumorigenesis, chemotherapy resistance, and poor prognosis. Effectively…
ISEF · 2026
Physics and Astronomy
Neutrino oscillation measurements aim to find fundamental physics beyond the Standard Model, but precision is limited by our inability to distinguish genuine signals from interfering nuclear…
ISEF · 2026
Engineering Technology: Statics & Dynamics
Fixed-wing UAVs have greater efficiency, flight range, and speed compared to traditional multirotor drones, making them more suitable for applications like geological surveillance, weather s…
ISEF · 2025
Chemistry
Acetaminophen is a widely used non-opioid analgesic and antipyretic medication, with over sixty million weekly consumers in the U.S. alone. Unfortunately, its toxicity is a leading cause of…
ISEF · 2025
Behavioral and Social Sciences
Pain management for terminal cancer patients often relies on opioids and invasive procedures, causing systemic side effects and psychological distress. This study developed 3D-printed hollow…
ISEF · 2025
Robotics and Intelligent Machines
With 35–40 million people worldwide requiring prosthetic or orthotic services, only 1 in 10 receive the care they need, primarily due to high costs. Soft robotics has emerged as a promising…
ISEF · 2025
Microbiology
Every one in five adults carry a genetic mutation related disease (Cross 2017). Current neoadjuvant and nanoparticle therapies are ineffective in treatment due to rapid tumor drug resistance…
ISEF · 2025
Engineering Technology: Statics & Dynamics
This research introduces a bio-inspired robotic tail exoskeleton designed to assist human balance, drawing inspiration from animals like cats and kangaroos. The device aims to address the si…
ISEF · 2025
Computational Biology and Bioinformatics
Autism Spectrum Disorder (ASD) is a heterogeneous neurological disorder affecting approximately 1 in 100 children today. The diagnosis and treatment of ASD are complex, partly due to its obs…
ISEF · 2025
Systems Software
This study investigates the application of OpenAI's Whisper Automatic Speech Recognition (ASR) model, fine-tuned to improve speech recognition accuracy for individuals with moderate to mild…
ISEF · 2025
Behavioral and Social Sciences
To bridge the gap between the increasing demand in the STEM workforce and the mathematician shortage, we constructed a children's book that combined the definition and applications of a comp…
ISEF · 2025
Chemistry
In our project, we examined the use of acids in the building demolition industry. Many structures from the mid 20th century are nearing the end of their lifespan for safe and effective use.…
ISEF · 2025
Translational Medical Science
Neurodegenerative disorders like Alzheimer’s disease affect approximately 55 million people worldwide and are expected to double every 20 years. Standard detection methods, such as cerebrosp…
ISEF · 2025
Chemistry
The purpose of this experiment was to see how hydrogen (H2) incorporation during production of thin films affects the stability and opto-electronic properties of various thin films. It was p…
ISEF · 2025
Physics and Astronomy
The growth of space debris in Low Earth Orbit (LEO) risks the current operation of satellites and spacecrafts. The Kessler Syndrome, in which debris is projected to grow at an exponential ra…
ISEF · 2025
Earth and Environmental Sciences
This project was meant to assess the public health risk posed by arsenic (As) in Texas drinking water on a local and statewide scale, find out if climate was affecting As concentrations stat…
ISEF · 2025
Behavioral and Social Sciences
Have you ever used the excuse “I work better under pressure” or found yourself procrastinating as you believe that working under stress will better your performance? Well, we tested the vali…