Browse real student projects, abstracts, and awards.
ISEF · 2026
Computational Biology and Bioinformatics
Major Depressive Disorder (MDD) negatively affects over 300 million people worldwide as the leading cause of disability, and suicide. Yet, current biomarkers fail to capture its biological h…
ISEF · 2026
Computational Biology and Bioinformatics
Parkinson's disease is the world's most rapidly growing neurodegenerative disease, and the cause is largely attributed to the misfolding of a protein in the brain known as alpha-synuclein (a…
ISEF · 2026
Translational Medical Science
Purpose: About 7.2 million Americans are living with Alzheimer's Disease (AD), with the number expected to to double by 2060. Currently used drugs for AD only reduce disease symptoms and mar…
ISEF · 2026
Chemistry
Industrial wastewaters from gold mining and other industries often contain highly toxic cyanide-based compounds that threaten ecosystems and human health. This project bibliographically inve…
ISEF · 2026
Materials Science
Many advanced technologies, from water purification membranes to battery electrolytes, rely on block copolymers (BCPs) because they can self-assemble into well-defined nanoscale morphologies…
ISEF · 2026
Physics and Astronomy
Dormant black holes (BHs) are believed to be among the most common types of BHs in the Milky Way; despite this, dormant BHs remain largely unstudied due to limitations of current methods of…
ISEF · 2026
Biochemistry
The main feature of cancer is that the cell's normal metabolic process has changed to allow for uncontrolled growth. Monocarboxylate transporter 2 (MCT2, encoded by SLC16A7) is responsible f…
ISEF · 2026
Materials Science
Antimicrobial resistance is expanding at an alarming rate, becoming the greatest global challenge of the 21st century with bacteria developing resistance to some of the best antibiotics and…
ISEF · 2026
Microbiology
Parkinson’s disease (PD) patients primarily receive the drug L-Dopa to replenish the natural stores of dopamine in the body to reduce PD symptoms (Nagatsu 2009). L-Dopa is structurally simil…
ISEF · 2026
Cellular and Molecular Biology
Flavonoids, a subclass of polyphenols, are known for their antioxidant and anti-inflammatory properties, potentially reducing the risk of cancer. This experiment tested the ability of five s…
ISEF · 2026
Biomedical Engineering
Expansion Microscopy (ExM) enhances spatial resolution by physically enlarging tissues, enabling detailed visualization without requiring advanced microscopy systems. ExM has proven effectiv…
ISEF · 2026
Physics and Astronomy
3D printing has the ability to control the internal structure of a product. Published research has not determined the strength-to-weight ratio of infill patterns. The isotropy of infill patt…
ISEF · 2026
Plant Sciences
Approximately 90% of plants have a mutualistic symbiosis with soil fungi, known as a mycorrhizal relationship. The plants and fungi exchange nutrients through the plant's roots. Mycorrhizae…
ISEF · 2026
Animal Sciences
Changes in temperature are known to have molecular effects on biological mechanisms. It has been found that when exposed to heat stress, Caenorhabditis elegans lose fertility and a general d…
ISEF · 2026
Plant Sciences
Before plants can be used as a food source for interplanetary missions, research must be conducted to determine the effects of microgravity on the growth of plants. This experiment was condu…
ISEF · 2026
Microbiology
Restoring severely eutrophic waters, especially in hardened urban river channels, is challenging and costly due to algal blooms, turbidity, microbial overgrowth, oxygen depletion, and nutrie…
ISEF · 2026
Animal Sciences
Global warming has become a major problem for organic agriculture, as changes in environmental conditions reduce the parasitization rate of Trichogramma, limiting the use and mass rearing of…
ISEF · 2026
Embedded Systems
Every year, on average, 37 children die from being left in vehicles out in the heat. This is a fatal mistake that can be avoided with a simple temperature detection and cooling system. The r…
ISEF · 2026
Plant Sciences
Leafy vegetables like Malabar spinach require optimal soil moisture (SM) to ensure steady physiological activity, improved nutrient uptake, and higher leaf yield. Excessive water application…
ISEF · 2026
Robotics and Intelligent Machines
Wetland ecosystems play critical roles in maintaining biodiversity, regulating hydrological processes, and supporting carbon sequestration—functions that align closely with United Nations Su…
ISEF · 2026
Earth and Environmental Sciences
Sub-Saharan Africa is vulnerable to variations in precipitation levels, as a large percentage of the population practices subsistence farming and most of their electricity is from hydropower…
ISEF · 2026
Mathematics
Strategic system stability depends on sustained cooperation, yet these frameworks frequently undergo phase transitions into competitive or destructive states. This research utilizes an entro…
ISEF · 2026
Computational Biology and Bioinformatics
It is well known that autism is a spectrum of various disorders rather than a single, discrete disorder. This makes it incredibly difficult to study since there appears to be a gradient in b…
ISEF · 2026
Biomedical and Health Sciences
This project is a three year study in investigating possible advancements that could made in the medical world. I created 3D printed casts and did comparative testing with different, more mo…
ISEF · 2026
Energy: Sustainable Materials and Design
Thermoelectric materials convert thermal energy directly into electrical energy based on Seebeck effect. An effective thermoelectric material must simultaneously possess a low thermal conduc…
ISEF · 2026
Biochemistry
It is crucial that cancer patients receive the proper medication dosage. Too high of a dose can be toxic; too low of a dose will not effectively kill cancer cells. Accurate dosing requires a…
ISEF · 2026
Embedded Systems
Commercial hearing aids struggle with poor speech clarity in noise, notably “cocktail party” settings. Many devices also distort the spatial cues critical for sound localization. As a result…
ISEF · 2026
Mathematics
Given P, a set of clients (points) in the plane, the task is to open a facility and connect each client to this facility while minimizing the connecting cost. If one assumes that this cost i…
ISEF · 2026
Plant Sciences
Weed infestations are considered as the most prominent biotic stressors threatening crop yields globally, contributing to 25-40% of annual crop losses. Currently, synthetic herbicides are mo…
ISEF · 2026
Robotics and Intelligent Machines
Animatronic Octopus Tentacle Kai McConnell Home school, Eustis, Florida, United States This engineering project, in the realm of soft robotics, has the opportunity to be world changing. This…