Browse real student projects, abstracts, and awards.
ISEF · 2025
Physics and Astronomy
The high fuel consumption rates of heavy combination trucks are unsustainable and damaging to the environment. When travelling at the recommended speed on interstate highways, most of a truc…
ISEF · 2025
Robotics and Intelligent Machines
Speech disorders such as stuttering, articulation errors, and atypical vocal patterns affect millions of children worldwide, limiting communication and confidence. Traditional therapy, while…
ISEF · 2025
Robotics and Intelligent Machines
Ornithopters have never fully replicated the efficiency of birds, which rely on complex kinematics that integrate thrust, lift, drag, and weight to optimize flight efficiency (Landell-Mills,…
ISEF · 2025
Environmental Engineering
The ornamental stone industry is responsible for the production of granites and marbles, but not all extracted material is used, as waste is discarded into nature due to its lack of added va…
ISEF · 2025
Biochemistry
Cancer cells can develop chemoresistance, causing treatment failure in over 90% of metastatic cancer patients. GPX4 inhibitors are promising ferroptosis inducers for chemoresistant tumors bu…
ISEF · 2025
Translational Medical Science
Cancer remains one of the most significant global health challenges, with the c-MYC proto-oncogene implicated in over 50% of cases, particularly in solid tumors. When dysregulated, c-MYC pro…
ISEF · 2025
Cellular and Molecular Biology
Hypoxia is common in solid tumors. Hypoxia Inducible Factor 1 Alpha (Hif1a) is upregulated and stabilized under hypoxic conditions, leading to tumor growth. This experiment targets Hif1a bec…
ISEF · 2025
Translational Medical Science
Histone Lysine Demethylase 4 (KDM4) and Mammalian Bromodomain and Extra-Terminal Domain (BET) are proteins that are highly dysregulated in multiple kinds of cancers. This study researched th…
ISEF · 2025
Computational Biology and Bioinformatics
Diabetes significantly worsens breast cancer (BC) progression by enhancing pathological angiogenesis through metabolic stress, increasing mortality rates by up to 40%. As molecular factors a…
ISEF · 2025
Biomedical and Health Sciences
Cancer has remained the leading cause of death globally, with the mutation of the Tumor Suppressor Gene TP53 via DNMT1 methylation occurring in 50% of cases. Current epigenetic therapies mis…
ISEF · 2025
Earth and Environmental Sciences
Coral reef ecosystems are rapidly deteriorating as they endure global threats leading to negative economic impacts, loss of cultural understanding and a decrease in habitat and biodiversity.…
ISEF · 2025
Physics and Astronomy
This study explores the dynamics of the restricted three-body problem within the field of celestial mechanics by utilizing Taylor integration via programming in the Julia language. This exte…
ISEF · 2025
Biomedical and Health Sciences
Pulmonary hypertension (PH) is a pulmonary vascular disease exhibiting a high mean arterial pressure (25mmHg at rest). Cellular hyperproliferation contributes to vascular remodeling, leading…
ISEF · 2025
Behavioral and Social Sciences
The study of linguistics, specifically that of perception and production of non-native languages, helps researchers better understand language learning mechanisms. By utilizing uncommonly sp…
ISEF · 2025
Cellular and Molecular Biology
In 2022, 2.3 million cases of breast cancer were diagnosed worldwide, with approximately 17% classified as triple-negative breast cancer (TNBC). TNBC is challenging to treat due to the absen…
ISEF · 2025
Chemistry
Heavy metal water contamination, specifically by hexavalent chromium (Cr(VI)), a carcinogenic byproduct of textile, rubber, and artificial fertilizer production, severely harms marine organi…
ISEF · 2025
Energy: Sustainable Materials and Design
The purpose of this project was to determine how to maximize the energy produced by a wind turbine. Wind turbines are an effective way to generate power without burning fossil fuels. Burning…
ISEF · 2025
Plant Sciences
Cotton is a cash fiber crop impacting the economies of over 80 countries. Salinity, an abiotic stress, is a major issue affecting cotton yield and fiber production. Improving salt tolerance…
ISEF · 2025
Microbiology
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter essential for stress regulation, mood stability, and anxiety reduction. Dietary factors such as artificial and flavors have b…
ISEF · 2025
Energy: Sustainable Materials and Design
Hand-powered generators are essential during natural disasters, military missions, and in developing nations. The paperfuge is a paper centrifuge that uses the supercoiling of string to reac…
ISEF · 2025
Computational Biology and Bioinformatics
Cancer is a complex disease affecting millions globally, encompassing various types such as breast, pancreatic and brain cancers, each requiring tailored treatment. A crucial enzyme in many…
ISEF · 2025
Animal Sciences
Damage to DNA can have serious health repercussions, like cancer and neurodegenerative disorders. However, antioxidants like ascorbic acid (also known as vitamin C) have shown to have positi…
ISEF · 2025
Animal Sciences
This study investigates the potential effects of hunting on the length of bison (Bison bison) bellows, a guttural vocalization which is essential to male-male competition and therefore femal…
ISEF · 2025
Plant Sciences
The limited variety of weed suppression treatments has contributed to herbicide resistance in several invasive species, threatening crop yields and global food security. Allelopathy—the natu…
ISEF · 2025
Engineering Technology: Statics & Dynamics
In modern spacecraft, hydrocarbon-based rockets can only reach a Specific Impulse (Isp) of 300-400s. This relatively low efficiency will be an issue on future, long-distance, space missions…
ISEF · 2025
Cellular and Molecular Biology
Toxic methylmercury (MeHg) readily crosses the blood brain and placental barriers, leading to developmental delays and neurological issues particularly with in utero exposure. Upon exposure,…
ISEF · 2025
Biochemistry
Tillandsia recurvata, better known as Texas ball moss, is an epiphyte native to the United States and commonly found in southern states including Texas, Florida, Louisiana, New Mexico, etc.…
ISEF · 2025
Materials Science
Mechanical recovery oil spill cleanup methods are unable to clean oil that sinks below the surface, and other methods can cause more pollution (in-situ burning). A method that is environment…
ISEF · 2025
Biomedical and Health Sciences
Short-read RNA sequencing is limited by its inability to fully sequence long genetic transcripts, requiring computational reconstruction that often hinders accurate characterization of trans…
ISEF · 2025
Physics and Astronomy
Sound waves are vibrations that travel through a medium and are characterized by frequency (pitch) and amplitude (volume). Humans can typically hear between 20 Hz and 20,000 Hz. A speaker is…