38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2025
Translational Medical Science
CTE, a progressive neurodegenerative condition from repetitive head impacts in sports, lacks preventive interventions. This research examines curcumin and CoQ10's neuroprotective effects in…
ISEF · 2025
Biomedical and Health Sciences
The therapeutic value of traditional plants in the Philippines remains underexplored. Thus, this study investigates the neuroprotective potential of Premna odorata leaf extract for Alzheimer…
ISEF · 2025
Cellular and Molecular Biology
Current underlying mechanisms to treat neurodegenerative diseases (ND) are limited due to an incomplete understanding. Tight junctions (TJ) and efflux pumps on the BBB restrict drug permeabi…
ISEF · 2025
Biomedical Engineering
Neurodegenerative diseases (NDDs), conditions characterized by damaged cell networks in the neurological system, are becoming increasingly prevalent as the global life-expectancy continually…
ISEF · 2025
Earth and Environmental Sciences
This study describes a novel species of snail in the genus Japonia (subfamily Cyclophoridae, family Cyclophoridae) discovered in Hong Kong. This species is distinguished by unique long, spoo…
ISEF · 2025
Physics and Astronomy
The possible existence of sub-solar mass black holes poses a challenge to current models of stellar evolution, as there is no known formation mechanism to produce such objects. There is some…
ISEF · 2025
Translational Medical Science
The widespread use of drugs, together with their limited specificity and poor biodistribution, poses significant challenges. Antibiotic resistance, aggravated by decades of uncontrolled cons…
ISEF · 2025
Physics and Astronomy Third Award
Simply expressed, antibubbles are the material opposite of soap bubbles. They consist internally of a virtually spherical volume of fluid that is separated from the surrounding fluid, typica…
ISEF · 2025
Environmental Engineering Fourth Award
Water pollution is a pressing global issue, exacerbated by inefficient wastewater treatment technologies that fail to remove emerging contaminants such as pharmaceuticals, antibiotics, and a…
ISEF · 2025
Engineering Technology: Statics & Dynamics Fourth Award
Drones are widely used in military and civilian applications, with VTOL (Vertical Takeoff and Landing) drones combining the vertical lift capability of helicopters with the horizontal cruisi…
ISEF · 2025
Materials Science Third Award
Smart, thermo-responsive polymeric gel compositions were developed using alginate-p-NIPAM (poly-N-isopropylacrylamide) and biocompatible conductive segments. These waterborne formulations we…
ISEF · 2025
Earth and Environmental Sciences Fourth Award
Lake-effect precipitation, which significantly impacts regions downwind of the Great Lakes, poses unique forecasting challenges due to its dependence on localized processes and intricate int…
ISEF · 2025
Animal Sciences
Hot Springs National Park (HOSP) has had two inventories of its amphibians and reptiles in the last 20 years. Despite limited results, they remain the most conclusive research of HOSP’s herp…
ISEF · 2025
Behavioral and Social Sciences Second Award
This study introduces an innovative intervention using sleep wave simulation therapy to treat panic attacks. Panic disorder is a disabling condition characterized by recurrent, unexpected pa…
ISEF · 2025
Chemistry Third Award
Light is a promising alternative to traditional reagents for synthesis due to its reduced environmental toxicity, ease of control, and lowered cost. Moreover, photochemisty’s ability to crea…
ISEF · 2025
Computational Biology and Bioinformatics Third Award
Alzheimer’s disease (AD) affects 1 in 9 individuals aged 65+ in the U.S., with females twice as likely as males. As AD pathology begins decades before symptoms appear, early detection and in…
ISEF · 2025
Materials Science Fourth Award
Over 40% of chemotherapy patients suffer toxic side effects due to non-specific targeting, and most genetic therapies are prematurely degraded before they can reach target organs, limiting t…
ISEF · 2025
Systems Software
A fractal is a mathematical object with non-integer dimensions, characterized by self-similar patterns repeating at different scales. They help describe intricate natural phenomena, like the…
ISEF · 2025
Environmental Engineering Second Award
With rising carbon dioxide (CO2) emissions accelerating climate change, carbon capture technologies have become essential. Cryogenic carbon capture (CCC) leverages low temperatures to separa…
ISEF · 2025
Chemistry First Award
In our research we focused on antivirotics, broad-spectrum drugs against RNA viral diseases. Galidesivir, a molecule that today appears to be the most optimal inhibitor of viral RdRp, became…
ISEF · 2025
Computational Biology and Bioinformatics
This project investigates the genetic mechanisms underlying Alzheimer's Disease (AD) and Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE) and their co-occurrence by analyzing diff…
ISEF · 2025
Physics and Astronomy Fourth Award
Flexible two-dimensional (2D) field-effect transistors (FETs) have gathered great interest, due to the need to solve scalability problems that are commonplace in 3D FETs. Specifically, the r…
ISEF · 2025
Biomedical and Health Sciences
Cardiovascular disease (CVD) causes 20.5 million deaths annually and imposes significant economic burdens due to rising healthcare costs. While pharmacological treatments and surgeries are t…
ISEF · 2025
Embedded Systems
Despite technological advancements in automation, the construction industry continues to primarily rely on manual labor. This project strives to implement autonomous masonry utilizing drones…
ISEF · 2025
Robotics and Intelligent Machines
The electricity demand for large language models (LLMs) has dramatically increased, driven by their intensive computational needs. Optimized Arithmetic via Ternary Networks (OATNet) is propo…
ISEF · 2025
Physics and Astronomy
Asteroid observation is vital for gathering lightcurve data, enabling the refinement of asteroid models, reconstruction of their three-dimensional shapes, and derivation of astrophysical pro…
ISEF · 2025
Behavioral and Social Sciences
Lacking adequate tools for early detection and treatment of Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) among Egyptian children and adolescents poses a crucial challenge. A…
ISEF · 2025
Mathematics
Purpose In this study, Rowlands' sequence, a recursive sequence discovered in 2003, was studied. The aim was to develop a conditional proof of: Conjecture 1: The first difference of Rowlands…
ISEF · 2025
Mathematics
This research looks to define a basis and the behavior of the Tau-divisor topology. This can be viewed as a permutation of the usual divisor topology by implementing the Tau-factorization th…
ISEF · 2025
Translational Medical Science First Award
Cancer is the second leading cause of death worldwide, affecting 20 million people and being responsible for >9.7 million deaths annually. Early prediction of clinical outcomes is crucial fo…