Browse real student projects, abstracts, and awards.
ISEF · 2025
Biomedical and Health Sciences
Leigh Syndrome (LS) is a rare mitochondrial disorder caused by mutations in the SURF1 gene, leading to reduced Complex IV enzymatic activity, impaired oxidative phosphorylation, and severe m…
ISEF · 2025
Biomedical and Health Sciences
Glioblastoma (GBM) is the most predominant malignant brain cancer in adults without prognosis improvement in decades. Nevertheless, 83% of GBM cases have Telomerase Reverse Transcriptase pro…
ISEF · 2025
Chemistry
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used in consumer products like non-stick cookware and food packaging since the 1950s. Due to their strong carbon-flu…
ISEF · 2025
Cellular and Molecular Biology
Aedes aegypti is a mosquito species that transmit diseases, including dengue fever, Zika virus and chikungunya. The control of A. aegypti populations is essential to prevent the spread of th…
ISEF · 2025
Biochemistry
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are widely used medications to treat pain, fever, and inflammation. These drugs function by inhibiting Cyclooxygenase (COX) enzymes, specifical…
ISEF · 2025
Translational Medical Science
Recent advancements in extended reality (XR), encompassing augmented reality (AR), virtual reality (VR), and mixed reality (MR), have demonstrated significant potential in transforming the m…
ISEF · 2025
Biochemistry
With rising mortality caused by breast cancer, it is necessary to develop early diagnostic techniques for rapid identification, prior to metastasis. Triple negative breast cancer (TNBC) make…
ISEF · 2025
Biomedical and Health Sciences
Breast cancer is the most common cancer worldwide and a complex disease characterized by genetic heterogeneity. Despite advancements in cancer management, the risk of recurrence and death re…
ISEF · 2025
Engineering Technology: Statics & Dynamics
This project aimed to improve the performance, efficiency, and strength of an ionic thruster, which uses corona discharge to create airflow. The goal was to enhance sealing, reduce air bleed…
ISEF · 2025
Robotics and Intelligent Machines
The purpose of this investigation is to design, build, and test a multi unmanned aerial vehicle (UAV) system for wide area object identification. Wide area object identification has applicat…
ISEF · 2025
Computational Biology and Bioinformatics
Non-alcoholic steatohepatitis is a progressive liver disease that is frequently underdiagnosed due to its asymptomatic nature in earlier stages. It is strongly associated with the presence o…
ISEF · 2025
Biomedical and Health Sciences
STAC3, known as Native American Myopathy, was first identified within the Lumbee tribe of North Carolina and is known to be an inherited mutation that causes congenital myopathy and musculos…
ISEF · 2025
Environmental Engineering
The excessive use of polystyrene (PS) in packaging has led to severe environmental concerns due to its non-biodegradability, large contribution to microplastic pollution, and harmful chemica…
ISEF · 2025
Behavioral and Social Sciences
Music is universally incorporated into various aspects of life in a plethora of ways. From culture, to listening to music in stores and restaurants, music is present and is well-known to exh…
ISEF · 2025
Earth and Environmental Sciences
Mycorrhizal fungi establish underground networks that form symbiotic relationships with almost all plant species and facilitate crucial ecological processes, but habitat degradation is their…
ISEF · 2025
Cellular and Molecular Biology
Genetics is an ever-expanding field of research. The genetic field has rapidly expanded from Mendel’s studies to genetically modified treatments, multi-allele variation knowledge, and studie…
ISEF · 2025
Robotics and Intelligent Machines
Nearly 1 in 8 people in the U.S. suffer from movement disorders, significantly impacting their quality of life. Neuromuscular disabilities cost the healthcare system $420 billion annually. D…
ISEF · 2025
Technology Enhances the Arts
Over 2.1 million people in the United States live with limb loss, with approximately 185,000 amputations occurring annually. Limb differences often pose challenges in using input devices suc…
ISEF · 2025
Chemistry
This research, conducted during a paid summer internship through ACS Project SEED, focused on synthesizing and analyzing N-3-HPA for their potential use in seizure management. To develop eff…
ISEF · 2025
Microbiology
Oral mucositis is an inflammation that causes pain and ulcers that affect cancer patients undergoing radiotherapy and/or chemotherapy. The condition is marked by oral mucosa inflammation, wh…
ISEF · 2025
Biomedical and Health Sciences
Helicobacter pylori is a bacterial strain that attaches to gastric mucosal cells through its BabA adhesin, which begins growth of colonies that increase risk of peptic ulcers and gastric or…
ISEF · 2025
Biochemistry
Amyloid-ß (Aß) extracellular plaques in the brain are a primary cause of Alzheimer’s Disease. Previous studies have focused on understanding cerebral Aß production and prevention. However, n…
ISEF · 2025
Earth and Environmental Sciences
Coastal erosion costs around $500 million per year due to damages to essential infrastructure (NOAA, 2025). Scientists have explored nature-based solutions to coastal erosion, specifically t…
ISEF · 2025
Robotics and Intelligent Machines
The most sought-after goal in machine learning is achieving artificial general intelligence, which requires stable memory and flexibility in learning. Existing models are dependent on all da…
ISEF · 2025
Physics and Astronomy
Traditional exoplanet detection methods often overlook multi-planet systems containing long-period or non-transiting planets due to observational biases favoring short-period transiting plan…
ISEF · 2025
Behavioral and Social Sciences
Animals can engage in lifelong learning because they can form, consolidate, and recall memories. Because sleep plays a vital role in consolidating newly acquired information and aiding recal…
ISEF · 2025
Embedded Systems
Chronic stress can severely impact mental and physical health, contributing to conditions like anxiety, depression, and cardiovascular issues. Inspired by an ancient Buddhist mindfulness bre…
ISEF · 2025
Biomedical Engineering
Current lower limb prostheses rely on cumbersome procedures, need risky surgery, and are prohibitively expensive. As a result, many lower-limb amputees experience unnatural gait patterns and…
ISEF · 2025
Computational Biology and Bioinformatics
Accurate classification of brain tumors is essential for effective patient treatment. In recent years, artificial intelligence has shown significant promise in improving medical diagnostics.…
ISEF · 2025
Biomedical Engineering
Neuroprosthetics offer more advanced functionality compared to traditional prosthetics, but their high cost and invasive procedures limit accessibility. This research focuses on developing a…