ISEF · 2014
Dengue or Leptospirosis?
Mathematics
The objective of the investigation was to determine if there is an underestimation of the cases of leptospirosis in relation to dengue in Puerto Rico. The need of the availability of the Mic…
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ISEF · 2014
Determining Antimicrobial and Synergistic Properties of Silver Coated Carbon Nanotubes and Antimicrobial Peptides against Streptococcus pyogenes
Mathematics Third Award
Streptococcus pyogenes is the bacterium responsible for streptococcal pharyngitis, impetigo, and rheumatoid fever. As antibiotics are often ineffective due to increasing antibiotic resistanc…
ISEF · 2014
Determining the Active Compound in Achyranthes aspera Leaf Extract and Its Effects on the Cell Cycle and Growth of Pancreatic Cancer Cells
Mathematics
Achyranthes aspera is a plant found commonly in parts of India and has been anecdotally noted to improve the prognosis of pancreatic cancer patients. Because 91% of newly diagnosed pancreati…
ISEF · 2014
Determining the Effect of Red Sea Sponge: Associated Bacteria against HIV-1 Integrase and HeLa Cancer Cell Line
Mathematics
In 2012, an estimated 2.3 million people were newly infected with HIV, while 14.1 million people were diagnosed with cancer. Marine sponges are considered to be habitats for numerous multitu…
ISEF · 2014
Developing an Antibacterial Wipe with Copper Species to Prevent the Growth of Escherichia coli
Mathematics
Initial experiments determined the effects of metallic copper on the growth of Escherichia coli. E.coli was exposed to copper metal strips and copper powder. The fine copper powder prevented…
ISEF · 2014
Development of a Multi-Sensory System to Better Relay Pharmacotherapy Information
Mathematics
This project consisted of the design and creation of a system for prescribers to provide medication instructions to patients via translation, visual representation, and audio in order to rep…
ISEF · 2014
Development of an Electroencephalography (EEG) Device for Evaluation of Mild Traumatic Brain Injury, Year Two
Mathematics Third Award
The effect of concussions on brain wave patterns was studied with a novel prototype device, incorporating a simple electroencephalography (EEG) headset, to assess its potential for concussio…
ISEF · 2014
Development of a Novel Antimicrobial Polymer for Biomedical Applications
Mathematics
Infections due to polymers in implants (catheters, prosthetics, etc.) remain a constant threat to public health, as implant-derived infections make up 50% of all nosocomial infections and co…
ISEF · 2014
Development of a Novel Blood-Based Diagnostic for Canine Lymphosarcoma
Mathematics Third Award
Lymphosarcoma (LSA) is the most common malignant neoplasia in dogs. BIN1 is a 20 exon, ubiquitous membrane-associated protein that, in cancer cells, is alternatively transcribed to include e…
ISEF · 2014
Development of Pollen Allergens Specific IgE Detection in Allergic Patient through the ELISA Technique
Mathematics
Pollen allergy has remained an important cause of severe allergy worldwide. While skin prick test is a gold standard for investigating allergies, however it is not practical in some patients…
ISEF · 2014
Dnmt3l: A New Genetic Factor in Obesity
Mathematics Fourth Award
Acetylation and methylation are garnering increasing attention for their respective roles in metabolic regulation through altering both gene expression and cytoplasmic enzyme activity. Howev…
ISEF · 2014
Does Aspartame or Insulin Affect the Regeneration of Planarian Worms?
Mathematics
The purpose of this research is to check the effects of aspartame and insulin on planarian regeneration. I am a diabetic and it has always interested me in how aspartame has raised my glucos…
ISEF · 2014
Early Cancer Diagnosis and Treatment through the Detection of Circulating Tumor Cells Using Drop-based Microfluidics
Mathematics First Award
This study employs the combination of a drop-based microfluidics platform and polymerase chain reaction (PCR) to create a breakthrough technology that enables the detection of circulating tu…
ISEF · 2014
Effect of Bacterial Quorum Sensing Molecule N-3-oxo-Dodecanoyl-L-Homoserine Lactone on Human Pancreatic Carcinoma Cells
Mathematics Fourth Award
In spite of chemotherapeutic and surgical advances, pancreatic cancer continues to have a dismal prognosis. Metastasis due to tumor cell migration remains the most critical challenge in trea…
ISEF · 2014
Effect of Ginger on Escherichia coli
Mathematics
The aim of this scientific project was to determine the effects of ginger on the growth of non-pathogenic Escherichia coli bacteria. First the growth of the bacteria was observed on solid LB…
ISEF · 2014
Effect of the Application of Carbon Dioxide in the Microbiology of Fresh Raw Milk
Mathematics
Currently, all commercial treatments to control bacterial populations in milk as well as liquid foods are based on extremely expensive thermal processes. The objective of this research was t…
ISEF · 2014
Elucidating the Mechanism of the Ketogenic Diet as an Effective Adjuvant Therapy for Malignant Glioma: A Multiphase Study to Characterize Alterations in Tumor-Associated Inflammatory and Growth Factor Signaling
Mathematics Fourth Award
In recent years, the ketogenic diet, a high-fat, low-carbohydrate and low-protein diet, has been shown to have potential as an effective adjuvant therapy for patients with malignant glioma.…
ISEF · 2014
Elucidating the Metabolism and Toxicity of Host-Derived Toxin Methylglyoxal in Mycobacterium Tuberculosis and Mycobacterium Smegmatis
Mathematics Third Award
In the past decade, tuberculosis has become the most significant global health challenge due to co-infection with HIV/AIDS, antibiotic resistance and the ineffectiveness of BCG. Methylglyoxa…
ISEF · 2014
Enhancing Pancreatic Islet Function in an Obese Mouse Model
Mathematics Third Award
The genetic explanation of Type II Diabetes has been long explored in hopes of developing a therapeutic treatment. Recent developments have led to the discovery of Betatrophin, an adipokine…
ISEF · 2014
Epithelial Mesenchymal Transition Enhances Perineural Invasion in Pancreatic Adenocarcinoma
Mathematics
Pancreatic adenocarcinoma is one of the most common causes of cancer-related death. Perineural invasion (PNI) occurs frequently in pancreatic adenocarcinoma and correlates with poor prognosi…
ISEF · 2014
ESCAPE from ESKAPE: Effect of Natural Substances on Penetration of Biofilms Formed by the ESKAPE Bacteria
Mathematics
The formation of biofilms on biomedical devices has become a major issue all over the world. People with biomedical implants often require several surgeries for replacement of their biomedic…
ISEF · 2014
Evaluation of Balance Skills in Male Subjects Aged 6-7 Years
Mathematics
The purpose of this investigation was to measure and compare the balance ability of male soccer players and sedentary control subjects between ages 6-7. 50 male soccer players and 50 male se…
ISEF · 2014
Evaluation of Delirium in the Intensive Care Unit Utilizing Confusion Assessment Methods
Mathematics
In this prospective study, “The Evaluation of Delirium in the ICU Utilizing CAM-ICU,” the impact of additional physical therapy for critically ill patients suffering from delirium will be ev…
ISEF · 2014
Evaluation of Herbal Product for Cure of Hemorrhoids
Mathematics
Hemorrhoids is the medical name for piles. They are the pillow like clusters of veins that lie just beneath the mucus membranes lining the lowest part of the rectum and the anus. Hemorrhoids…
ISEF · 2014
Evaluation of Ventricular Mass for Hypertrophic Cardiomyopathy using 4D Echocardiography
Mathematics
Background: Ventricular mass determination is essential for evaluation of the progress of Hypertrophic cardiomyopathy (HCM). Four-dimensional echocardiography (4DE) has been shown able to de…
ISEF · 2014
Evolution of Developing an Alternative Treatment for Candida albicans using Natural Plant Extracts
Mathematics Fourth Award
An alternative treatment using natural plant extracts was investigated for the opportunistic fungal pathogen, Candida albicans. Infections with this pathogen are frequently seen in immunocom…
ISEF · 2014
Fat Content of Beef
Mathematics
Two major concerns in households today are living a healthy lifestyle and saving money. Beef is a highly consumed product in the United States, and in order to make it healthier, the leaner…
ISEF · 2014
Fighting for the Orange Ribbon: Acute Myeloid Leukemia Type-3 Differentiation Triggered by Cisplatin
Mathematics Fourth Award
Acute Myeloid Leukemia (AML) is estimated to affect over 18,000 people in the United States this year. It occurs when there’s a blockage in differentiation. AML type 3 doesn’t have a chemoth…
ISEF · 2014
Genetic and Immunological Responses to Infection with Periodontal Pathogens in the Development of Atherosclerotic Vascular Disease in ApoE -/- Mice
Mathematics
Periodontal Disease and Atherosclerotic Vascular Disease are the two most prevalent diseases both affecting nearly 200 million people globally. This research study helps us to understand the…
ISEF · 2014
Hepatocyte Differentiation of hESC Cultured Under Xeno-Free and Feeder-Free Conditions
Mathematics Fourth Award
End stage liver diseases can only be cured by whole liver transplantation. Because of limited supply of donor livers the supply will never meet the demand. Stem cells have shown to provide a…