Browse real student projects, abstracts, and awards.
ISEF · 2018
Computational Biology and Bioinformatics
Multiple sequence alignments, alignments of three or more biological sequences play a critical role in phylogenetic tree development and identification of evolutionarily conserved regions. E…
ISEF · 2018
Computational Biology and Bioinformatics
Pathogen populations are not static, but instead sporadically mutate, posing a difficult threat to combat as they evolve to resist antibiotics. Fortunately, we can look to genetics to help p…
ISEF · 2018
Computational Biology and Bioinformatics
Alzheimer’s Disease (AD) significantly reduces memory, communication, focus, and reasoning skills in elderly individuals. There is no known cure with progressive deterioration. Early identif…
ISEF · 2018
Computational Biology and Bioinformatics Fourth Award
Type 2 diabetes mellitus (T2DM) affects the lives of millions of people through its life-altering complications. Worldwide, 3.4 million people die of diabetes annually. It is known that T2DM…
ISEF · 2018
Computational Biology and Bioinformatics
Protein folding and computational origami are gradually becoming revolutionary fields. With our ability to computationally analyze minuscule biological structures, we are making significant…
ISEF · 2018
Computational Biology and Bioinformatics
There are a wide variety of Beta-globin related disorders including sickle cell disease and Beta-thalassemia. There are five main genes in the Beta-globin locus: epsilon, gamma two, gamma on…
ISEF · 2018
Computational Biology and Bioinformatics
Electroencephalography (EEG) headsets, being highly portable, present a convenient, noninvasive method of recording the brain’s electrical activity. This project seeks to develop a method fo…
ISEF · 2018
Computational Biology and Bioinformatics
Recent research has determined that genes are regulated by a complex, changing network of DNA spatial interactions. However, current wet-lab technologies for characterizing the 3D genome are…
ISEF · 2018
Computational Biology and Bioinformatics Second Award
Dyslexia is the world’s most common neurological learning disability - it affects 1 in every 10 people worldwide. And though it has been proven that an early diagnosis can significantly redu…
ISEF · 2018
Computational Biology and Bioinformatics
Antimicrobial resistance (AMR) is a major threat to global public health with 10 million people at risk of dying from AMR-related causes by 2050. Understanding the underlying biological fact…
ISEF · 2018
Computational Biology and Bioinformatics Fourth Award
With the ever-increasing popularity of renewable energy, many are beginning to explore the possibility of using solar arrays in domestic and/or compact, urban environments. For the average p…
ISEF · 2018
Computational Biology and Bioinformatics
The bacterial species of Burkholderia are renown by scientists to be extremely difficult to distinguish. As a result, melioidosis, which is one of the many diseases caused by Burkholderia, h…
ISEF · 2018
Computational Biology and Bioinformatics
Lichen species cover nearly 8% of the earth’s surface and are overlooked in genetic studies. Because lichen are composed of bacteria, fungi, and algae, separating and sequencing a three-part…
ISEF · 2018
Computational Biology and Bioinformatics
NFKBIA deletions are extremely prevalent in cases of both Breast Cancer and Glioblastoma, and this study aims at identifying genes disproportionately affected by these deletions. First, gene…
ISEF · 2018
Computational Biology and Bioinformatics
I used Big Data (> 2.3 million records) to identify predictors of peripheral neuropathy (PN). PN costs the U.S. over 10 billion annually, so predicting factors may lead to large cost savings…
ISEF · 2018
Computational Biology and Bioinformatics
Autism spectrum disorder is a heritable, developmental disorder affecting 1 in 68 children in the United States. Development of a more definitive diagnostic method is especially critical for…
ISEF · 2018
Computational Biology and Bioinformatics
Alzheimer's affects about 70-80% of all dementia patients around the world. This neuroimaging study is aimed to examine the various numerical and quantifiable differences in volumetric measu…
ISEF · 2018
Computational Biology and Bioinformatics
PD-L1 and PD-L2 are two transmembrane proteins created by cancerous tumors that have an affinity towards PD-1, a protein receptor expressed by T Cells. I If these proteins bind to the recept…
ISEF · 2018
Computational Biology and Bioinformatics Third Award
With the growing prevalence of Type 1 Diabetes (T1D), the complete loss of insulin production among children and adults, the artificial pancreas is becoming increasingly necessary to combat…
ISEF · 2018
Computational Biology and Bioinformatics
Throughout the history of drug discovery, an enzymatic-based approach for identifying new drug molecules has been primarily utilized. Recently, protein-protein interfaces that can be disrupt…
ISEF · 2018
Computational Biology and Bioinformatics
Hospital Acquired Infections (HAI) are of growing concern in the healthcare market because they lead to a 6% mortality rate, increase the average length of stay for a patient from five to tw…
ISEF · 2018
Computational Biology and Bioinformatics Second Award
This interdisciplinary study develops a novel diagnostic and monitoring tool for early stage schizophrenia (SCZ) by modeling diffusion MRI tractography abnormalities and discovering regions…
ISEF · 2018
Computational Biology and Bioinformatics Fourth Award
Stroke is the leading cause of severe disabilities in the developed world, often leaving people physically shut out from society despite their functional minds. Current solutions for rehabil…
ISEF · 2018
Computational Biology and Bioinformatics
The intrinsic subtype of breast cancer is a major factor considered in the development of individualized treatment regimens for patients. An understanding of when and which molecular changes…
ISEF · 2018
Computational Biology and Bioinformatics
Fatty acid binding proteins (FABPs) are a group of macromolecules that regulate lipid activity in cells and function as lipid transporters. Notably, the inhibition of certain FABPs, namely F…
ISEF · 2018
Computational Biology and Bioinformatics Third Award
Glioblastoma Multiforme (GBM) is one of the most aggressive types of brain cancer, the most common malignant brain tumor amongst adults, and has a mean survival time of 12 months post-diagno…
ISEF · 2018
Computational Biology and Bioinformatics
Chronic Traumatic Encephalopathy (CTE) is a medical condition that results from head impact injuries in contact sports. A Boston University study reports occurence of CTE in 87% of the cases…
ISEF · 2018
Computational Biology and Bioinformatics Third Award
Over 90% of cancer-associated mutations are non-coding, driving tumor development by impeding transcription factor binding – the “on and off switches” regulating key cell life and death gene…
ISEF · 2018
Computational Biology and Bioinformatics
Human immunodeficiency virus (HIV) destroys a person’s immune system by attacking the T-cells of the immune system and using them as viral replicating hosts. As a result, a person infected w…
ISEF · 2018
Computational Biology and Bioinformatics First Award
Chronic disease is the leading cause of death in the world. Next generation therapeutics are needed to combat the growing global health crisis of chronic diseases, such as cancers and heart…