Browse real student projects, abstracts, and awards.
ISEF · 2018
Computational Biology and Bioinformatics
Autism spectrum disorder is a heritable, developmental disorder affecting 1 in 68 children in the United States. Development of a more definitive diagnostic method is especially critical for…
ISEF · 2018
Computational Biology and Bioinformatics
Alzheimer's affects about 70-80% of all dementia patients around the world. This neuroimaging study is aimed to examine the various numerical and quantifiable differences in volumetric measu…
ISEF · 2018
Computational Biology and Bioinformatics
PD-L1 and PD-L2 are two transmembrane proteins created by cancerous tumors that have an affinity towards PD-1, a protein receptor expressed by T Cells. I If these proteins bind to the recept…
ISEF · 2018
Computational Biology and Bioinformatics Third Award
With the growing prevalence of Type 1 Diabetes (T1D), the complete loss of insulin production among children and adults, the artificial pancreas is becoming increasingly necessary to combat…
ISEF · 2018
Computational Biology and Bioinformatics
Throughout the history of drug discovery, an enzymatic-based approach for identifying new drug molecules has been primarily utilized. Recently, protein-protein interfaces that can be disrupt…
ISEF · 2018
Computational Biology and Bioinformatics
Hospital Acquired Infections (HAI) are of growing concern in the healthcare market because they lead to a 6% mortality rate, increase the average length of stay for a patient from five to tw…
ISEF · 2018
Computational Biology and Bioinformatics Second Award
This interdisciplinary study develops a novel diagnostic and monitoring tool for early stage schizophrenia (SCZ) by modeling diffusion MRI tractography abnormalities and discovering regions…
ISEF · 2018
Computational Biology and Bioinformatics Fourth Award
Stroke is the leading cause of severe disabilities in the developed world, often leaving people physically shut out from society despite their functional minds. Current solutions for rehabil…
ISEF · 2018
Computational Biology and Bioinformatics
The intrinsic subtype of breast cancer is a major factor considered in the development of individualized treatment regimens for patients. An understanding of when and which molecular changes…
ISEF · 2018
Computational Biology and Bioinformatics
Fatty acid binding proteins (FABPs) are a group of macromolecules that regulate lipid activity in cells and function as lipid transporters. Notably, the inhibition of certain FABPs, namely F…
ISEF · 2018
Computational Biology and Bioinformatics Third Award
Glioblastoma Multiforme (GBM) is one of the most aggressive types of brain cancer, the most common malignant brain tumor amongst adults, and has a mean survival time of 12 months post-diagno…
ISEF · 2018
Computational Biology and Bioinformatics
Chronic Traumatic Encephalopathy (CTE) is a medical condition that results from head impact injuries in contact sports. A Boston University study reports occurence of CTE in 87% of the cases…
ISEF · 2018
Computational Biology and Bioinformatics Third Award
Over 90% of cancer-associated mutations are non-coding, driving tumor development by impeding transcription factor binding – the “on and off switches” regulating key cell life and death gene…
ISEF · 2018
Computational Biology and Bioinformatics
Human immunodeficiency virus (HIV) destroys a person’s immune system by attacking the T-cells of the immune system and using them as viral replicating hosts. As a result, a person infected w…
ISEF · 2018
Computational Biology and Bioinformatics First Award
Chronic disease is the leading cause of death in the world. Next generation therapeutics are needed to combat the growing global health crisis of chronic diseases, such as cancers and heart…
ISEF · 2018
Computational Biology and Bioinformatics
Empirical evidence demonstrates that an organism’s phenotypes are often based on multiple interdependent genes, rather than a single gene. When the expression of a phenotype is predicated on…
ISEF · 2018
Computational Biology and Bioinformatics
Detecting rare cell types would allow very early disease diagnosis (e.g., cancer, infection), identification of new cell types, and deepen our understanding of cell differentiation. We devel…
ISEF · 2018
Computational Biology and Bioinformatics Fourth Award
Kinesins are motor proteins that move unidirectionally along microtubules as they hydrolyze ATP. Although the general features of the kinesin walking mechanism are becoming increasingly clea…
ISEF · 2018
Computational Biology and Bioinformatics
Epilepsy is a very common and devastating neurological disorder that affects 65 million people globally. Electroencephalography (EEG) recording is an essential tool in evaluating seizure act…
ISEF · 2018
Computational Biology and Bioinformatics
P53 is an important tumor suppressor protein, that when mutated will lead to much higher cancer rate. This project constructed a phylogenetic tree using the mRNA sequences for p53 gene in 20…
ISEF · 2018
Computational Biology and Bioinformatics
Sensory hearing hair-cells are vulnerable to multiple damaging agents. In mammals, which lack regeneration, hair-cell loss leads to permanent hearing impairment. In contrast, non-mammalian v…
ISEF · 2018
Computational Biology and Bioinformatics
Ischemic strokes, caused by limited blood flow to the brain due to clotted arteries, account for 88% of all strokes, and are one of the leading causes of death worldwide. Although a cure has…
ISEF · 2018
Computational Biology and Bioinformatics
Parkinson’s disease (PD) is identified and associated with symptoms such as changes in gait stability, slowness of movement, essential tremor, and changes in cognitive function. Symptoms and…
ISEF · 2018
Computational Biology and Bioinformatics
The purpose of this in-silico experiment was to explore a way to model the transition of bacterial populations (persister and normal). The hypothesis theorizes that by studying the role of r…
ISEF · 2018
Computational Biology and Bioinformatics
States and the CDC monitor accidental and intentional violent deaths to answer questions that are critical for the development of effective violence prevention strategies. The National Viole…
ISEF · 2017
Computational Biology and Bioinformatics
It was previously reported, that temperature may significantly influence neural dynamics on different levels of brain modeling. Therefore, in computational neuroscience, we would like to con…
ISEF · 2017
Computational Biology and Bioinformatics
Unlike homogeneous cellular bodies, cancer is best understood as a diverse community of heterogeneous cells that interacts through complex ecological interactions. Intratumor interactions, s…
ISEF · 2017
Computational Biology and Bioinformatics
Safe, effective, and reliable gene therapy has been heralded as the future of medicine in the 21st century. Technologies for editing and regulating genes based on the CRISPR/Cas9 system have…
ISEF · 2017
Computational Biology and Bioinformatics
Microarray technologies are used to understand the driving forces in genomics and proteomics through high-throughput measurements of interactions among DNA, RNA, peptides, and proteins. Univ…
ISEF · 2017
Computational Biology and Bioinformatics
Alzheimer’s affects 44 million people worldwide but has no preventive cures. This study created a novel methodology for Alzheimer’s (AD) and Mild Cognitive Impairment’s (MCI) early detection…