Browse real student projects, abstracts, and awards.
ISEF · 2023
Computational Biology and Bioinformatics
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that obstructs airflow and causes difficulty breathing. It is responsible for approximately 3.2 million de…
ISEF · 2023
Computational Biology and Bioinformatics
Metabolism forms the foundation of understanding how cellular processes work; however, not all reactions within a metabolic network are fully understood. Some specific metabolic pathways in…
ISEF · 2023
Computational Biology and Bioinformatics
Pulmonary fibrosis occurs when lung tissue becomes damaged or scarred and can be progressive in nature, impacting an individual’s ability to breathe. Idiopathic pulmonary fibrosis (IPF) and…
ISEF · 2023
Computational Biology and Bioinformatics
With a prevalence of 2-8% of the world population, the insidious disease Fibromyalgia(FM) posses a threat. Fibromyalgia is a chronic-pain disorder characterized by widespread musculoskeletal…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Cardiovascular disease (CVD) is the leading cause of human death, accounting for 17.8 million deaths in the past year. CVD causes dysfunction in blood proteins and cells. These dysfunctions…
ISEF · 2023
Computational Biology and Bioinformatics
Acute Kidney Injury (AKI) is a major clinical complication with an incidence of 50% among critical care patients and an observed in-hospital mortality of 62%. The early identification of pat…
ISEF · 2023
Computational Biology and Bioinformatics
The early division of nuclei in a Drosophila embryo is composed of eight nuclear divisions, or cycles, producing a total of 256 nuclei by the eighth cycle. The nuclei start in the center of…
ISEF · 2023
Computational Biology and Bioinformatics Second Award
Breast Cancer (BC) is the most commonly diagnosed cancer and is a significant cause of death worldwide, affecting around 2.3 million women annually. Triple-negative breast cancer (TNBC) is a…
ISEF · 2023
Computational Biology and Bioinformatics
In past work, invasive implants that implement a process called deep brain stimulation (DBS) in order to regenerate sight for the visually impaired have been investigated. DBS is a surgical…
ISEF · 2023
Computational Biology and Bioinformatics
Colorectal cancer (CRC) has multiple subtypes, and it may take patients weeks to find out which subtype they have. The goal of this research is to use gene expression data to determine poten…
ISEF · 2023
Computational Biology and Bioinformatics
Hepatocyte growth factor receptor (HGFR or c-MET) is a receptor tyrosine kinase that has been found to be linked to cancer, with malignant mutations causing tumor growth, angiogenesis, and m…
ISEF · 2023
Computational Biology and Bioinformatics
Hi-C, a chromosome conformation capture-based method, allows researchers to interrogate chromatin interactions between any two genomic loci in a bulk of cells and study the spatial arrangeme…
ISEF · 2023
Computational Biology and Bioinformatics Third Award
Microbial DNA is a novel analyte for early cancer detection. Although recent studies have found distinct communities of bacteria and fungi between tumor types, they have not investigated mic…
ISEF · 2023
Computational Biology and Bioinformatics
The inefficient treatment of thousands of diseases contributes to the need for a quick and cost-efficient alternative to current drug discovery methods. Drug development is extremely time-co…
ISEF · 2023
Computational Biology and Bioinformatics
Eye diseases can potentially cause blindness in patients. Cataracts are the leading cause of blindness, accounting for over 51% of blindness worldwide. Glaucoma and diabetic retinopathy foll…
ISEF · 2023
Computational Biology and Bioinformatics
Have you ever wondered where your fingerprints come from? The purpose of this project was to determine if fingerprints are genetically inherited through biological factors or relations and o…
ISEF · 2023
Computational Biology and Bioinformatics
The aim of this work is to create a program capable of simulating the evolution of organisms together with geological processes. For simplicity, I have focused on the evolution of prokaryote…
ISEF · 2023
Computational Biology and Bioinformatics
There are ethnic differences in c-reactive protein and another on how the gene APOL1 can affect millions of African Americans. Genetic ancestry and socioeconomic conditions are factors to wh…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Drug discovery, a complex and time-consuming process, heavily relies on determining affinities between drugs and targets. With the introduction of computational methods, researchers can now…
ISEF · 2023
Computational Biology and Bioinformatics
One in twenty-six people worldwide develops epilepsy during their lifetime, including myself. Around 30% of epilepsy patients are nonresponsive to medication. It is important to identify the…
ISEF · 2023
Computational Biology and Bioinformatics
miRNAs are small, non-coding RNAs significant in numerous biological processes and disease pathways, proven heavily dysregulated in cancers, with prior literature revealing their potential a…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
West Nile virus (WNV) is the most impactful mosquito-borne disease in the United States. Since 1999, it has caused over 2,500 deaths and has seriously harmed quality of life for thousands of…
ISEF · 2023
Computational Biology and Bioinformatics Second Award
Neural networks are fundamentally flawed. In even the most trivial tasks like digit recognition, they require tens of thousands of training examples to achieve near-human accuracy. In contra…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
A key drawback of traditional chemotherapy drugs like cisplatin is that they target both healthy and cancerous cells and are highly toxic in high or medium doses. The Warburg Effect states t…
ISEF · 2023
Computational Biology and Bioinformatics
Rare, aggressive pediatric brain tumor ETMR is frequently misdiagnosed, reducing chances of survival. Early diagnosis is crucial due to its short average 12 month prognosis. While ETMR is ch…
ISEF · 2023
Computational Biology and Bioinformatics
Every single cell in an organism has a membrane that, in addition to being a compartmental barrier, plays a role in maintaining cell shape and function. For example, sickle cell anemia is a…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Purpose: Liver cancer (Hepatocellular carcinoma) is one of the most common and fatal cancers. Subtypes associated with poor outcomes need proper characterisation. “Macrotrabecular-massive He…
ISEF · 2023
Computational Biology and Bioinformatics
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide, but disease-modifying treatments are still lacking. Poly (ADP-ribose) polymerases (PARPs) consume nicotina…
ISEF · 2023
Computational Biology and Bioinformatics
Computer modeling allows for simulating unknown events of the past and the future. Since specific details about the evolutionary process are unknown, I created a model to analyze predator an…
ISEF · 2023
Computational Biology and Bioinformatics First Award
Replication errors represent two-thirds of cancer mutations. A novel subset, micro-changing short tandem repeats (mcSTRs), lack systematic examination in cancers due to complex chromosomal a…