Browse real student projects, abstracts, and awards.
ISEF · 2024
Computational Biology and Bioinformatics
P-glycoprotein (P-gp) is found in various tissues throughout the body, acting as an efflux pump that actively transports substances out of cells. As a result, P-gp plays an important role in…
ISEF · 2024
Computational Biology and Bioinformatics
With over 18 million new cancer diagnoses and nearly 10 million associated deaths per year, cancer remains a significant global health challenge. Pancreatic cancer is one of the deadliest fo…
ISEF · 2024
Computational Biology and Bioinformatics
This study aims to develop novel mathematical approaches for cancer treatment, specifically targeted gene therapy for cancer stem cells (CSCs) within tumors. CSCs, or ancestral cells, are ta…
ISEF · 2024
Computational Biology and Bioinformatics
Stem cells play a central role in the development of organisms; hence, studying them is of great importance. RE:IN modeling of systems involving them allows us to investigate their behaviors…
ISEF · 2024
Computational Biology and Bioinformatics
This study presents a computer simulation of a contact virus being spread by carriers in rectangular rooms with different width-to-length shapes. The simulated scenario is one where a predet…
ISEF · 2024
Computational Biology and Bioinformatics
Leigh Syndrome is a disorder that typically appears during childhood or before birth and it is caused by mutations in the mitochondrial protein SURF1. Although more than 80 mutations have be…
ISEF · 2024
Computational Biology and Bioinformatics
Alzheimer's Disease (AD) is a leading cause of death, affecting over 55 million worldwide. Despite its prevalence, there is no effective treatment or cure for AD. The acetylcholinesterase (A…
ISEF · 2024
Computational Biology and Bioinformatics
Glioblastoma multiforme is one of the deadliest forms of brain tumors. Many genes are associated with its formation, progression, and survival, but no consensus has been reached on which som…
ISEF · 2024
Computational Biology and Bioinformatics
HIV infection remains a global public health challenge. While current drug treatments effectively suppress HIV viral loads below the detection level, complete eradication of the virus remain…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
Breast cancer affects 2.3 million women annually with the five-year survival rate for Triple-negative-breast-cancer (TNBC) being 12%. Current immunotherapy treatments are effective only in 2…
ISEF · 2024
Computational Biology and Bioinformatics
Background: Predicting origins of premature ventricular complexes (PVCs) based on a 12-lead electrocardiogram (EKG) is a laborious process. Artificial intelligence can automate the process m…
ISEF · 2024
Computational Biology and Bioinformatics
My research provides the theoretical storage of data in DNA, expressed using the four natural “A,” “C,” “G,” and “T” DNA nucleobases. The DNA-stored information may be actual biological geno…
ISEF · 2024
Computational Biology and Bioinformatics
This study investigates the relationship between the sequential organization of the brain, measured by functional magnetic resonance imaging (fMRI) scans, and both rest and task-based differ…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
B-cell acute lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML) are the 2 most common leukemias. The American Cancer Society estimates that there will be 59,610 leukemia cases a…
ISEF · 2024
Computational Biology and Bioinformatics Third Award
The rising prevalence of neurodegenerative dementia highlights the need for improved diagnostic accuracy. Many proposed clinical decision support systems (CDSS) require multiple disparate da…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
Globally, numerous living organisms suffer from viral infections. Genome annotation is the process of mapping coding-sequences (CDS) of a genome. CDS are the portions of the genome that are…
ISEF · 2023
Computational Biology and Bioinformatics
Over 50 million Americans have an Autoimmune Disease (AD). Diagnosis of symptoms is challenging and the available treatments are invasive and costly. As chronic diseases, ADs often significa…
ISEF · 2023
Computational Biology and Bioinformatics
Deep brain stimulation (DBS) is a novel therapy for Parkinson's disease, in which an electrode is surgically implanted into the patient's brain and remotely controlled to send an electrical…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Determining neuronal identity in imaging data is an essential task in neuroscience, facilitating the comparison of neuronal activity across organisms. Cross-organism comparison, in turn, ena…
ISEF · 2023
Computational Biology and Bioinformatics
Animal venoms consist of toxin peptides and proteins, and drugs derived from venoms are unique in their ability to interfere with key biological processes in the body, such as blood clotting…
ISEF · 2023
Computational Biology and Bioinformatics Third Award
Over the last few decades, many breast cancer patients have become disease-free due to the advancements in detection, diagnosis, and treatment. However, cancer can come back for almost 30% o…
ISEF · 2023
Computational Biology and Bioinformatics
By 2040, the global cancer burden will rise to 30 million new cases annually, with the greatest increases affecting low-to-middle-income countries. Current diagnosis methods, such as physica…
ISEF · 2023
Computational Biology and Bioinformatics Fourth Award
Dysregulation of protein phosphorylation during cellular development and signal transduction is associated with a myriad of human cancers, Parkinson’s Disease, and Alzheimer’s Disease. Under…
ISEF · 2023
Computational Biology and Bioinformatics Third Award
Miniature-sized shape morphing Microbots are increasingly gaining momentum in several medical applications, including targeted drug delivery and the removal of blood clots. There has been si…
ISEF · 2023
Computational Biology and Bioinformatics First Award
In mid-2022, Mpox reemerged with heightened infectivity and transmissibility, causing 30,000 cases in just six months. As we recovered from COVID-19, fear of another pandemic heightened. Two…
ISEF · 2023
Computational Biology and Bioinformatics
As global life expectancy improves, the population of the elderly, persons that are aged 65 years and older, is steadily increasing as well. However, with aging populations a greater prevale…
ISEF · 2023
Computational Biology and Bioinformatics
Cocaine addiction is an issue that affects more than 5 million people in America per year. Despite past progress in cocaine addiction research, there are many specific questions left unanswe…
ISEF · 2023
Computational Biology and Bioinformatics
Hyperinflammation is the most severe clinical phase of Covid-19 disease and is characterized by high blood pressure in the lungs, which facilitates microthrombus formation, eventually leadin…
ISEF · 2023
Computational Biology and Bioinformatics
Zooxanthellae expulsion (Coral bleaching) is a significant concern for biodiversity and economic prosperity, considering mass bleaching has now occurred in every region worldwide. This study…
ISEF · 2023
Computational Biology and Bioinformatics
The Human Immunodeficiency Virus (HIV-1) is a globally prevalent virus that attacks CD4 cells in the human immune system, decreasing the quality and length of life for those affected. The mo…