Browse real student projects, abstracts, and awards.
ISEF · 2024
Computational Biology and Bioinformatics
The World Health Organisation’s Blueprint Priority Disease Nipah henipavirus’ (NiV) deadly pandemic potential has been evidenced by outbreaks across the world. High mortality rates of up to…
ISEF · 2024
Computational Biology and Bioinformatics
Globally, cancer is the leading cause of death, with 1.9 million new diagnoses and 600,000 deaths annually attributed to lung cancer alone. Non-small cell lung cancer (NSCLC) represents appr…
ISEF · 2024
Computational Biology and Bioinformatics
Kidney cancer treatment depends on several factors, such as cancer subtype and stage. It is extremely important that the doctor knows what subtype of kidney cancer their patient has in order…
ISEF · 2024
Computational Biology and Bioinformatics Second Award
Conventionally, tumorigenesis is understood as a gradual accumulation of genetic mutations. Yet, chromoplexy rearrangements (ChRs) are a mutational phenomenon characterized by highly complex…
ISEF · 2024
Computational Biology and Bioinformatics
Each year, the escalating drug epidemic causes over 100,000 deaths in the US. 80% of these mortalities result from multiple drug use toxicity, which yields unpredictable and potentially fata…
ISEF · 2024
Computational Biology and Bioinformatics
Mucin-1 MUC1 is a high molecular weight glycoprotein that can overexpress, causing various cancers and playing a significant role in tumor progression and metastasis. Developing targeted the…
ISEF · 2024
Computational Biology and Bioinformatics
Cell viability analysis (MTT assay) can detect subtle changes in cellular metabolic activity at low concentrations, providing a sensitive assessment of cytotoxicity and survival capability.…
ISEF · 2024
Computational Biology and Bioinformatics Second Award
In recent years, generative machine learning algorithms have been successful in designing innovative drug-like molecules. SMILES is a sequence-like language used in most effective drug desig…
ISEF · 2024
Computational Biology and Bioinformatics
Melanoma is a type of skin cancer that originates in melanocytes, the pigment-producing cells, and is known for its potential to metastasize and become life-threatening if not detected and t…
ISEF · 2024
Computational Biology and Bioinformatics
There are approximately 40 million imaging diagnostic errors annually worldwide (Itri, et al, 2018). Roughly 795,000 people in the U.S. alone die or are permanently disabled due to misdiagno…
ISEF · 2024
Computational Biology and Bioinformatics
The most common biological neuron spiking computational model is the Integrate&Fire (I&F) model. It computes the neuron's potential by summing its inputs and fires spikes accordingly. The Fi…
ISEF · 2024
Computational Biology and Bioinformatics
Progressive Supranuclear Palsy(PSP) is a neurodegenerative disease that affects many individuals over the age of 60. Unfortunately, more than 30% of patients with PSP are misdiagnosed as hav…
ISEF · 2024
Computational Biology and Bioinformatics Second Award
Respiratory Syncytial Virus (RSV) poses significant health risks, especially to infants under six months and adults over 65. The objective of this study is to deepen the understanding of str…
ISEF · 2024
Computational Biology and Bioinformatics Third Award
Deep learning, particularly generative models, have shown promise to expedite the drug discovery process by generating novel molecules with desirable properties/bioactivity. Current research…
ISEF · 2024
Computational Biology and Bioinformatics
Oxidative stress is a precursor to numerous cancers, including the Grade IV glioblastoma, affecting >300,000 people annually. However, the identification of oxidative stress markers remains…
ISEF · 2024
Computational Biology and Bioinformatics
Traditional drug discovery is costly, slow, and has low FDA approval rates. Deep learning models such as GAN, VAE, & reinforcement learning (RL) have emerged as a solution, using SMILES or g…
ISEF · 2024
Computational Biology and Bioinformatics
The human microbiome is a term for the community of microorganisms living in the human body. The composition of the microbiome has the ability to influence the expression of various diseases…
ISEF · 2024
Computational Biology and Bioinformatics
Alzheimer's disease (AD) is a complex neurodegenerative disorder with no cure, despite decades of research. More than six million adults in America are living with Alzheimer’s and the number…
ISEF · 2024
Computational Biology and Bioinformatics
Apple snails are an invasive species in the southeastern United States, who host the rat lungworm which is very detrimental to humans. Currently the main control method for apple snails is p…
ISEF · 2024
Computational Biology and Bioinformatics
Transdermal drug delivery (TDD) has emerged as a reliable alternative to invasive drug administration techniques. However, current methods used to test the process of TDD are inefficient and…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
The aim of this research is to detect tumor tissue during brain surgery using data preprocessing and machine learning. Brain tumors are the leading cause of cancer-related death in children…
ISEF · 2024
Computational Biology and Bioinformatics Third Award
Parkinson's Disease (PD) is a neurodegenerative disease that causes gradual impairment of an individual through mutations in the SNCA (Synuclein Alpha) gene. Currently, there exist no widely…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
In the human brain, high amounts of metabolic energy are required to maintain neural activity. A large fraction of this energy is expended in the generation and firing of action potentials,…
ISEF · 2024
Computational Biology and Bioinformatics
Colorectal cancer (CRC) represents a major health challenge with significant mortality rates. Due to the difficulties in early intervention, many patients fail to receive optimal therapeutic…
ISEF · 2024
Computational Biology and Bioinformatics
Native Hawaiian Pacific Islanders (NHPI) suffer disproportionately from cardiometabolic health conditions compared to other major ethnic groups. This study aimed to address critical gaps in…
ISEF · 2024
Computational Biology and Bioinformatics
Affecting 60-70% of the 55 million dementia patients in the world, Alzheimer's Disease (AD) has established itself as one of the most profound neurodegenerative diseases in today's society.…
ISEF · 2024
Computational Biology and Bioinformatics First Award
Alzheimer's Disease (AD) has neither satisfactory nor equitably accessible treatments. Current research emphasizes inflammation, notably age-related elevation of microglial TNF-a, in driving…
ISEF · 2024
Computational Biology and Bioinformatics
Dysregulated metabolism is a hallmark of cancer progression yet exactly how cancer cells vary their metabolic program during tumorigenesis remains unknown. Moreover, metabolism is highly dyn…
ISEF · 2024
Computational Biology and Bioinformatics Third Award
Cellular reprogramming holds immense promise for novel therapeutics in fields like disease reversion and cellular regeneration. This field aims to control or perturb gene expression to induc…
ISEF · 2024
Computational Biology and Bioinformatics
B-cell acute lymphoblastic leukemia (B-ALL), the most common pediatric cancer, is characterized by the proliferation of immature, leukemic B-lymphocytes in the bone marrow. CAR-T cell therap…