Browse 737 real Computational Biology and Bioinformatics projects from ISEF, with abstracts, awards and links to the original entries.
ISEF · 2026
Computational Biology and Bioinformatics
Mapping long - range axonal projections is critical for understanding neural circuit dysfunction in neurodegenerative diseases. While machine learning ( ML ) tools have advanced volumetric c…
ISEF · 2026
Computational Biology and Bioinformatics
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults, with ~22,000 new cases and ~11,000 deaths in the USA annually. AML subtypes require distinct treatment proto…
ISEF · 2026
Computational Biology and Bioinformatics
Alzheimer's disease (AD) is the most common neurodegenerative disorder and a leading cause of dementia worldwide, making early and accurate staging critical for research and care planning. A…
ISEF · 2026
Computational Biology and Bioinformatics
The false killer whale (Pseudorca crassidens), one of Hawai?i's most endangered marine mammals, is difficult to monitor visually because of its deep-sea distribution and behavioral avoidance…
ISEF · 2026
Computational Biology and Bioinformatics
Dementia affects more than 55 million people worldwide, and its prevalence is projected to nearly triple by 2050. A major clinical challenge is identifying individuals who are likely to expe…
ISEF · 2026
Computational Biology and Bioinformatics
Parkinson disease (PD) remains a progressive neurodegenerative disorder that is characterized by dopaminergic neuronal loss, immune metabolic dysregulation, and chronic neuroinflammation. Th…
ISEF · 2026
Computational Biology and Bioinformatics
Current CRISPR guide design tools rank on single scores without multi-module integration. This project seeks to develop machine learning models to predict optimal CRISPR-Cas9 Guide RNA seque…
ISEF · 2026
Computational Biology and Bioinformatics First Award
Agricultural pesticide use remains substantial, increasing chemical exposure, environmental burden, and production costs. U.S. farms spent $21.7 billion on agricultural chemicals in 2024. Be…
ISEF · 2026
Computational Biology and Bioinformatics
Enzymes are widely used across healthcare, textiles, and environmental technologies, requiring optimization through enzyme engineering. Traditional approaches rely on wet-lab trial-and-error…
ISEF · 2026
Computational Biology and Bioinformatics Third Award
Epilepsy is a neurological disorder characterized by recurrent seizures, and affects nearly 50 million people, causing ~140,000 deaths worldwide annually. Many of these deaths could be preve…
ISEF · 2026
Computational Biology and Bioinformatics First Award
Background: Rupture of cerebral aneurysm, an abnormal bulging of the arterial wall, can lead to brain hemorrhage and stroke. Endovascular surgical treatment is highly invasive and poses sign…
ISEF · 2026
Computational Biology and Bioinformatics Second Award
Nearly 50% of human IVF embryos arrest before reaching the blastocyst stage, yet the molecular mechanisms causing this failure remain poorly understood. Current literature examines omics in…
ISEF · 2026
Computational Biology and Bioinformatics
Major Depressive Disorder (MDD) negatively affects over 300 million people worldwide as the leading cause of disability, and suicide. Yet, current biomarkers fail to capture its biological h…
ISEF · 2026
Computational Biology and Bioinformatics
Parkinson's disease is the world's most rapidly growing neurodegenerative disease, and the cause is largely attributed to the misfolding of a protein in the brain known as alpha-synuclein (a…
ISEF · 2026
Computational Biology and Bioinformatics
It is well known that autism is a spectrum of various disorders rather than a single, discrete disorder. This makes it incredibly difficult to study since there appears to be a gradient in b…
ISEF · 2026
Computational Biology and Bioinformatics Fourth Award
Crohn's Disease (CD) is a chronic autoimmune condition characterized by intense inflammatory flares. CD is incurable, and available medications carry severe side effects. With few head-to-he…
ISEF · 2026
Computational Biology and Bioinformatics
Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 18 million people worldwide. Many treatments rely on monoclonal antibody drugs that block inflammatory signals such…
ISEF · 2026
Computational Biology and Bioinformatics Second Award
Structural comparison between proteins is key to many research tasks, including evolutionary analysis, peptidomimetics, and functional annotation. Traditional structure alignment tools such…
ISEF · 2026
Computational Biology and Bioinformatics Second Award
Drug–target interaction (DTI) prediction is a crucial step in modern drug discovery. Accurate and efficient predictions can substantially reduce costs and development time. While deep learni…
ISEF · 2026
Computational Biology and Bioinformatics
The steady decline in bee population over the past several decades has led to an overall decrease in crop yields and poorer food quality. Today, there are no known tools available on the mar…
ISEF · 2026
Computational Biology and Bioinformatics
Declared a global crisis by the World Health Organization, antibacterial resistance causes over 5 million deaths annually. Existing models optimize binding affinity at a single evolutionary…
ISEF · 2026
Computational Biology and Bioinformatics Second Award
Resistance to targeted therapies in non-small cell lung cancer (NSCLC) limits treatment efficacy. Mathematical models have shown promise in predicting resistance development by capturing bio…
ISEF · 2026
Computational Biology and Bioinformatics
Multiple mechanisms contribute to Autism Spectrum Disorder (ASD), including mutations in the SHANK2 gene. SHANK2 encodes a postsynaptic scaffolding protein that organizes key excitatory rece…
ISEF · 2026
Computational Biology and Bioinformatics
Brain age gap estimation(BrainAGE) has emerged as a powerful biomarker in human neuroimaging, offering insight into deviations from normative aging trajectories and providing a sensitive ind…
ISEF · 2026
Computational Biology and Bioinformatics
Gliomas are the deadliest brain tumors with recurrence rates of up to 90%. Without an accurate map of the tumors’ heterogeneity, surgeons operate with limited knowledge of tumor margins, oft…
ISEF · 2026
Computational Biology and Bioinformatics
Coral reefs are some of the most biodiverse ecosystems on Earth, but are increasingly prone to bleaching due to warming ocean temperatures and acidification. Selective breeding of corals, es…
ISEF · 2026
Computational Biology and Bioinformatics
Parkinson's disease (PD) and Lewy Body Dementia (LBD) are two neurodegenerative disorders that are caused by the abnormal misfolding and aggregation of the same protein, a-synuclein. Despite…
ISEF · 2026
Computational Biology and Bioinformatics
Glioblastoma multiforme (GBM) is a highly aggressive and vascularized brain tumor with poor prognosis and limited therapeutic options. Endocan (ESM1), a tumor-associated endothelial proteogl…
ISEF · 2026
Computational Biology and Bioinformatics Third Award
Reliable characterization of cell states, which encompass a cell's function, environment, and structure, is fundamental to comprehending healthy cell function and transition into diseased st…
ISEF · 2026
Computational Biology and Bioinformatics
PFAS (per- and polyfluoroalkyl substances) are organohalogens that are dubbed “forever chemicals” because they can remain in the environment for over 1,000 years. Chlorination-derived disinf…