ISEF · 2021
Beat the Heat
Biomedical and Health Sciences
Do spices affect you in a way you don’t want to be affected? Perhaps you want to be relieved from the pain you suffer. Well my experiment might have what you are looking for! The results I f…
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38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2021
Breakdown of Gluten Proteins Using a Newly Identified Combination of Fruit Derived Enzymes to Alleviate Symptoms of Gluten Intolerance
Biomedical and Health Sciences
BACKGROUND- Three million people in the U.S alone suffer from gluten intolerance/celiac disease. My aim is to identify which of the natural fruits, and herbs have the ability to breakdown gl…
ISEF · 2021
Butyrate: Bridging Bench to Bedside -- Bringing Hope for Better Diagnostic and Therapeutic Options for Peanut Allergies
Biomedical and Health Sciences First Award
Background: Distinctive roles for T-lymphocyte:Bacteroides fragilis cross-talk occurs in dampening peanut allergic responses. Butyrate is key to B.fragilis regulation of immune homeostasis.…
ISEF · 2021
Change in Lung Volume with Recovery Positions
Biomedical and Health Sciences
For years, track coaches have insisted that runners put their hands on their head because this was the recognized best recovery position. Recent studies done by Western Washington University…
ISEF · 2021
Characterization of Brown Pine Needle Extract for the Treatment of Acne and Atopic Dermatitis
Biomedical and Health Sciences
In this study, we investigated the biological activities of brown pine needles of pine tree for the chronic inflammatory skin disorder such as acne and atopic dermatitis. The Minimum Inhibit…
ISEF · 2021
Chronic Sleep Deprivation Induces Brain Inflammation via CCR2-mediated Peripheral Monocyte Infiltration
Biomedical and Health Sciences Second Award
Chronic sleep deprivation (CSD), a result of consistent sleep loss, is a global concern in more than half of adults worldwide. Research has shown that people with CSD are more susceptible to…
ISEF · 2021
Colorimetric Smartphone-Based Detection of Salivary SOD2 on Photonic Opal Structures for the Rapid Diagnosis of Hepatocellular Carcinoma
Translational Medical Science
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Currently, HCC is diagnosed through blood tests, invasive liver biopsies, and costly imaging tests; and…
ISEF · 2021
Combating Alzheimer’s Disease: An Exploration of Resveratrol Treatment and Early Disease Detection Using Drosophila melanogaster and Machine Learning
Translational Medical Science
Alzheimer's Disease (AD) is a neurodegenerative disease that destroys memory and thinking. This study focused on two critical gaps in AD research: novel treatment identification and early di…
ISEF · 2021
Combined Artificial Intelligence and Nano-cell Internalization to Predict Cancer Aggressiveness
Biomedical and Health Sciences
Cancer is a leading cause of death worldwide. After the cancer diagnosis, the oncologist will stage cancer and devise an effective treatment plan. Novel methods to predict the severity is a…
ISEF · 2021
Comparative Analysis of Genetic Mutations and Overall Survival in Patients with Glioblastoma Multiforme: A Retrospective Cohort Study
Biomedical and Health Sciences
Glioblastoma multiforme (GBM) is a highly aggressive and rapidly growing brain cancer that affects the central nervous system and typically leads to death within 15 months of diagnosis. It i…
ISEF · 2021
Comparing the Efficacy of Dietary Fibers vs a Sap from Acacia Tree: Gum Arabic
Biomedical and Health Sciences
Over 1.2 billion people suffer from constipation each year and in the US alone $725 million are spent on laxatives per year. The most commonly used treatments are stool softeners, osmotic, a…
ISEF · 2021
Connection ICU: A Novel Mobile Application to Prevent Delirium in the Intensive Care Unit
Translational Medical Science
Patients with delirium suffer severe confusion, paranoia, hallucinations, and struggle to understand or pay attention to what is happening. The COVID-19 pandemic has worsened the already sev…
ISEF · 2021
Correlating Sugar Consumption with Hormone Production Using Shmoo Formation in S. Cerevisiae
Biomedical and Health Sciences
Polycystic Ovary Syndrome (PCOS) and insulin resistance have been known for years to be correlated statistically. However, no one has been able to confirm which one causes the other. In an a…
ISEF · 2021
Curcumin and Capsaicin Synergistically Suppress Neuroblastoma Development
Biomedical and Health Sciences Third Award
Neuroblastoma is one of the most common malignant pediatric tumors, accounting for 10% of all childhood cancer deaths. However, current treatment methods often involve chemotherapeutic agent…
ISEF · 2021
Cure of Breast Cancer, Year 4: First Discovery of Target Therapy for Aggressive Hormonal Breast Cancer using Clinical Database and 3D Model
Biomedical and Health Sciences Second Award
The anti-estrogen tamoxifen is a highly effective hormonal therapy for hormonal (HR+) breast cancer patients. However, the estrogen receptor-negative, progesterone receptor–positive (ER-/PR+…
ISEF · 2021
Deciphering the Cellular Effects and Bioavailability of Moringa oleifera Leaf Extract
Biomedical and Health Sciences
Currently, growing interest has emerged on the beneficial effects of plant-based diets for the prevention of chronic diseases. Studies have shown that polyphenol compounds possess preventive…
ISEF · 2021
Deep Neural Network Analysis of Clinical Variables Predicts Escalated ICU Care in COVID-19 Patients
Biomedical and Health Sciences Fourth Award
This study used deep learning neural networks to investigate the most important clinical variables that could be used to determine escalated care early on in COVID-19 patients. Hospitalized…
ISEF · 2021
Determining the Effect of a Disulfiram Copper Complex on Drug Resistance Through Deletion of ALDH1 in Metastatic Breast Cancer Cells (A Three Year Study)
Translational Medical Science
Cancer is one of the leading causes of death in the U.S., with about 1 in 8 women developing invasive breast cancer in her lifetime. Drug repurposing, an underused treatment, is crucial for…
ISEF · 2021
Determining the Prognostic Value of the DNA Methylation of the GYPC, NME1, and SLIT2 Genes in Human Lung Adenocarcinoma
Translational Medical Science
Lung cancer is responsible for the highest number of cancer-related deaths worldwide, and lung adenocarcinoma is its most common subtype. This study used statistical analysis to determine th…
ISEF · 2021
Developing an Opioid Painkiller Alternative Using the Epigenetic Correlation Between the Nav1 VGSC Family and miRNAs 30b & 182
Translational Medical Science
The opioid crisis has taken a huge toll on our country. Noting that in 2018, nearly 22% of opioid related deaths in the U.S. were due to prescription painkiller overdose, this research aims…
ISEF · 2021
Developmental Neurotoxicity of Artificial Sweeteners and Ethanol in Danio rerio Embryos
Translational Medical Science
Over 70 countries approve the consumption of artificial sweeteners (Ogungbemi et al., 2019). People, including pregnant women, consume them to substitute sugar in drinks such as diet soda (P…
ISEF · 2021
Development of an Innovative Alternative Model for Teratogenicity Testing: Effect of Hypervitaminosis A in Regenerating Planaria
Translational Medical Science Fourth Award
According to the Center for Disease Control and Prevention, a child with birth defects is born approximately every 4.5 minutes. The currently accepted method to determine the potential of ne…
ISEF · 2021
Development of a Protocol for Simultaneously Sequencing Multiple Inherited Retinal Diseases’ Founder Mutations
Biomedical and Health Sciences
Inherited retinal diseases may cause retinal degeneration which can lead to blindness. There are about 250 different genes associated with inherited retinal diseases resulting in many differ…
ISEF · 2021
Development of Monodispersed Hollow Silica Nanospheres Loaded with 5-Fluorouracil to Enhance the Drug Delivery on Breast Cancer Cell Line MCF-7
Translational Medical Science
Statistical reports have shown that 627,000 women worldwide died from breast cancer in 2018. There are many useful drugs available today. However, the obstacles in cancer chemotherapy are th…
ISEF · 2021
Diabetes Mellitus and Alcohol
Biomedical and Health Sciences
PURPOSE: The aim of our research was to evaluate the effects of ethanol and some amino acids mixture on alloxan-induced diabetic rats, to study their behavior changes and to investigate bloo…
ISEF · 2021
Diagnosing and Classifying Aphasia: Employing Deep Learning to Accelerate Recovery in Aphasic Stroke Victims
Translational Medical Science Fourth Award
Over 2 million Americans suffer from aphasia, a condition that affects stroke victim’s ability to communicate. Aphasia has no medical cure, but it can be improved through extensive speech-la…
ISEF · 2021
Diagnosing the Stage of COVID-19 using Machine Learning on Breath Sounds
Translational Medical Science Third Award
With rapidly increasing COVID-19 cases, patients with mild and moderate symptoms are being asked to home-isolate themselves to save hospital resources for more severe patients. Such patients…
ISEF · 2021
Dietary Protein:Carbohydrate Ratio Impacts Development and Locomotion of Drosophila melanogaster
Biomedical and Health Sciences
The American diet, rich in carbohydrates, has been implicated in the rise of metabolic syndrome. Metabolic syndrome includes various conditions that increase a person’s risk for cardiovascul…
ISEF · 2021
Differential Expression Analysis and Transcriptomic Characterization of Glioma Progression
Biomedical and Health Sciences Fourth Award
Gliomas make up nearly a third of all brain tumors and are extremely aggressive in later stages, with only a 5% five-year survival rate. Each year, approximately 20,000 people are diagnosed…
ISEF · 2021
Differential Expressions of Wnt Pathway Proteins of Colorectal Carcinoma Metastases to Liver versus Lung
Biomedical and Health Sciences
Isolated liver and lung metastases in colorectal carcinoma are both stage IVA. However, not all stage IV tumors are the same. The lungs act as a waypoint for further metastatic spread, sugge…