Browse real student projects, abstracts, and awards.
ISEF · 2024
Biomedical and Health Sciences
Handwriting is defined as a complex neurophysiological process that involves multiple aspects including visual-motor, memory, and linguistic aspects as well as multiple subsections of the ce…
ISEF · 2024
Translational Medical Science
The inability of deep learning (DL) models to explain their output, known as the AI “Black Box” problem, greatly hinders clinical adoption of DL models in healthcare. This study is the first…
ISEF · 2024
Biomedical and Health Sciences
Cancer is one of the major adverse health issues in the world, and is the second leading cause of death amongst Native Hawaiians. Ovarian cancer specifically, is known to have a stronger eff…
ISEF · 2024
Biomedical and Health Sciences
Introduction While the incidence of esophageal adenocarcinoma is rapidly increasing, the prognosis remains poor with a five-year survival rate of 20%. Therefore, the discovery of new molecul…
ISEF · 2024
Biomedical and Health Sciences
Chronic kidney disease (CKD) results in a progressive loss of kidney function over time, affecting 37 million in the US. Chymase is the primary enzyme mediating angiotensin II formation inde…
ISEF · 2024
Biomedical and Health Sciences
Over 1 million deaths annually can be attributed to suicide, yet no biomarkers exist. This study investigated blood-brain barrier (BBB) disruption by examining claudin-5 (CLDN5) epigenetic a…
ISEF · 2024
Translational Medical Science
Traumatic Brain Injury (TBI) is an intracranial damage common among soldiers and impact-sport athletes. In severe cases, TBI is associated with neurodegeneration and dementia if left untreat…
ISEF · 2024
Biomedical and Health Sciences
Chimeric Antigen Receptor (CAR) T cells and Bispecific T cell Engagers (BiTEs) are two novel immunotherapy platforms. I hypothesized that the different mechanisms used by anti-CD3-CD19 BiTEs…
ISEF · 2024
Translational Medical Science
Duchenne Muscular Dystrophy (DMD) is an inherited X-linked disease with an incidence of 1:3,600. Patients become weak at 2-3 years old with progression to a wheelchair in their early teens,…
ISEF · 2024
Biomedical and Health Sciences
Glioblastoma Multiforme (GBM) is an aggressive and fast-growing form of brain cancer with a high rate of mortality. It is the most common malignant brain tumor in adults, accounting for 47.7…
ISEF · 2024
Biomedical and Health Sciences
Systemic sclerosis (SSc) is an autoimmune disease with multiple organ involvement, including lung, skin, gastrointestinal tract, and kidneys. A subset of SSc patients develops a critical ren…
ISEF · 2024
Biomedical and Health Sciences
Facioscapulohumeral muscular dystrophy (FSHD) is a genetic, progressive myopathy and the second most common muscular dystrophy. Progression of the disease primarily begins in the facial, sho…
ISEF · 2024
Translational Medical Science
The visual similarity of melanoma and seborrheic keratosis has made it difficult for elderly patients with disabilities to know when to seek medical attention, contributing to the metastasis…
ISEF · 2024
Biomedical and Health Sciences Third Award
Circadian disruptions have been implicated in the oncogenesis of multiple cancers. However, the underlying mechanisms linking circadian rhythms and cell cycles remain unclear, posing a signi…
ISEF · 2024
Translational Medical Science Second Award
Inflammatory Bowel Disease (IBD) is a prevalent autoimmune condition that affects 2.39 million Americans and is characterized by an excess of inflammatory cytokines. Interleukins, a class of…
ISEF · 2024
Translational Medical Science
Around 800 million individuals worldwide are estimated to have chronic kidney disease (CKD), with most cases being undiagnosed. Diagnosing CKD and other renal dysfunctions requires an assess…
ISEF · 2024
Biomedical and Health Sciences
I characterized placenta and fetal brain tissues on the cellular level by leveraging single-cell (sc)RNA-seq data from pregnant pigtail macaques (Macaca nemestrina). My hypothesis was that t…
ISEF · 2024
Translational Medical Science Second Award
Across neurological drug development, researchers struggle with the inability of most drugs to pass through the blood-brain barrier (BBB), due to the semipermeable membrane’s high selectivit…
ISEF · 2024
Translational Medical Science
Currently, 6.2 million adults suffer from heart failure (HF), with 30-40% surviving one-year post-hospitalization and a 30-day readmission rate of 23%. The urgent need for an affordable, spe…
ISEF · 2024
Translational Medical Science
Biodegradable polymers are often used to seek applications addressing specific needs, such as wound care, due to their compatibility with biological interfaces, are eco-friendly, and safe fo…
ISEF · 2024
Biomedical and Health Sciences Fourth Award
Adoptive Cell Therapy (ACT) is a promising form of Immunotherapy, wherein T-Lymphocytes are propagated in the laboratory and re-infused into patients. However, a major limitation to ACT is C…
ISEF · 2024
Biomedical and Health Sciences
Triple-negative breast cancer (TNBC) is a molecular subset of breast cancer defined by a lack of estrogen, progesterone, and the human epidermal growth factor 2 (HER2) receptors. Currently,…
ISEF · 2024
Biomedical and Health Sciences Fourth Award
UGT1A1 is an enzyme involved in metabolizing Irinotecan, a DNA topoisomerase class I inhibitor chemotherapeutic drug. Polymorphisms within the UGT1A1 promoter reduce UGT1A1 mRNA expression,…
ISEF · 2024
Translational Medical Science
Commonly known as the yellow water lily root or kaandoosh in Ojibwe language, the rhizome of Nuphar advena is utilized by Indigenous communities for treating bacterial overgrowth. This study…
ISEF · 2024
Biomedical and Health Sciences
Ankylosing Spondylitis a type of rheumatic autoimmune disorders where normal body cells attack musculoskeletal cells, making bones' weak joints unstable and prone to fractures. This can caus…
ISEF · 2024
Biomedical and Health Sciences
Colorectal Cancer (CRC) is the second leading cause of cancer death. This is because during early stages, CRC is difficult to catch, which means that treatment can only be offered after the…
ISEF · 2024
Translational Medical Science
Decidualization is a key process in the endometrium, facilitating embryo implantation through morphological changes of the endometrium. Dysregulation of this process is prevalent in individu…
ISEF · 2024
Biomedical and Health Sciences
UV light damages every ocular structure including the cornea, lens, and the retina. Although anterior structures of the eye absorb 99% of UV light, some UV radiation does reach the retina. C…
ISEF · 2024
Translational Medical Science
Dengue virus (DENV-III) has been declared an epidemic in many Southeastern Asian and Eastern African nations; its highest incidence rate is in Bangladesh. Bangladesh set the precedent for en…
ISEF · 2024
Translational Medical Science Third Award
Every 2 seconds, cardiovascular disease (CVD) steals a life. 12-lead electrocardiography (ECG) is the gold standard for CVD diagnosis, which is specialist-reliant and mainly available in urb…