Browse real student projects, abstracts, and awards.
ISEF · 2018
Translational Medical Science
Powassan virus is a causative agent of tick-borne encephalopathy that has shown a 375% increase in the United States in the last five years alone. There is currently no cure for infection by…
ISEF · 2018
Translational Medical Science Fourth Award
Curcumin has gained prominence for its pharmacological and medicinal applications, including antioxidant and anticarcinogenic properties. However, its low oral-bioavailability and stability…
ISEF · 2018
Translational Medical Science
Diseases are diagnosed based on physical attributes that define the disease. Many diseases such as cancer rely on invasive methods such as biopsy for detection. Others are hard to detect ear…
ISEF · 2018
Biomedical and Health Sciences
The most common cause of Acute Myeloid Leukemia is the mutation of the NPM1 protein. Cells can only differentiate when NPM1 is in the nucleus because the protein NPM1 carries with it master…
ISEF · 2018
Biomedical and Health Sciences
The reason for this science fair project was to see if body mass index (BMI), stomach girth, and skinfold measurements indicated whether individuals are pre-disposed to diabetes. The hypothe…
ISEF · 2018
Biomedical and Health Sciences
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the human gastrointestinal tract with no known cure; periods of subsided inflammation are followed by periods of hyper…
ISEF · 2018
Translational Medical Science Third Award
WHO estimates that around 12 million children (2-5% children worldwide) suffer from amblyopia - the most common visual impairment among children. Neurocognitive development is dependent on p…
ISEF · 2018
Biomedical and Health Sciences Third Award
Glioblastoma is the most common and aggressive type of brain tumor in adults, primarily treated with the chemotherapeutic agent Temozolomide (TMZ). However, many tumors are initially resista…
ISEF · 2018
Biomedical and Health Sciences Third Award
Background/Hypothesis: Multiple system atrophy (MSA) is a fatal neurodegenerative disorder with unknown mechanisms and no curative treatment. The rationale for this work came from a clinical…
ISEF · 2018
Biomedical and Health Sciences
When diagnosing intraductal lesions in breast tissue, pathologists evaluate architectural, morphologic and at times immunohistochemical features to classify the disease. However, in the medi…
ISEF · 2018
Biomedical and Health Sciences
Hypertrophic cardiomyopathy (HCM) is a common heart disease that causes sudden cardiac arrest in people of all ages. In this research, we tested six chemotherapy drugs that reinforced separa…
ISEF · 2018
Translational Medical Science
This study aimed to detect corneal arcus. The detection of corneal arcus by image analysis has important signi?cance for the disintegration of abnormal lipid metabolism. Corneal arcus is a l…
ISEF · 2018
Biomedical and Health Sciences First Award
The student researcher previously concluded that East Indian Sandalwood Oil (EISO) inhibits AGS gastric cancer cells by inhibiting a TRPM7-like ion channel recorded via automated patch clamp…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Alzheimer’s dementia (AD) is a neurodegenerative disease that affects one out of three seniors. It has killed more people than breast and prostate cancer together, making it the sixth leadin…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Despite increased research and treatment options, cancer continues to increase. To test treatments for this deadly disease, 2D microenvironments are currently used in lab settings. Only 10%…
ISEF · 2018
Translational Medical Science
Liver Fibrosis is the creation of scar tissue in the liver after it suffers damage, and it can lead to cirrhosis and hepatocellular cancer. There are currently no standard treatments for liv…
ISEF · 2018
Biomedical and Health Sciences
Sepsis affects microcirculation and tissue perfusion leading to tissue hypoxia and multiple organ dysfunction. Red blood cells (RBCs) play the critical role of tissue oxygenation, thus funct…
ISEF · 2018
Biomedical and Health Sciences
Tauopathies, for example Alzheimer’s disease (AD), affect over 5.5 million Americans, and are estimated to affect 16 million people by 2050. Tauopathies are diseases caused by the damage of…
ISEF · 2018
Biomedical and Health Sciences Third Award
The purpose of this experiment was to compare seven coronary rotational atherectomy device head designs (spherical with 3, 4, or 5-holes, conical with 3, 4, or 5-holes, & control with no hol…
ISEF · 2018
Translational Medical Science Third Award
The increase in the global population, an increase of elderly, combined with new surgical interventions and possibilities lead to an overall increase of surgeries. Every year there over 50 m…
ISEF · 2018
Translational Medical Science
Programmed Death Ligand 1, or PD-L1, is a transmembrane protein upregulated in numerous tumors. By binding to the PD-1 receptors on CD8+ T-cells, these tumors can evade T-cells’ cytotoxic ef…
ISEF · 2018
Translational Medical Science
MIT researchers stimulated gamma waves in genetically modified mice brains with flashing lights to trigger microglia to clean up beta amyloid plaques (the cause of Alzheimer’s Disease). The…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Topotecan (TPT) is a chemotherapeutic drug frequently used to treat lung cancer, which is the leading cause of cancer-related death in the US. However, the development of drug resistance in…
ISEF · 2018
Biomedical and Health Sciences
Mesenchymal stem cells (MSCs) present a high degree of clonal heterogeneity, making it difficult to identify which cells are capable of repopulating tissues versus those more prone to underg…
ISEF · 2018
Biomedical and Health Sciences
Purpose: Lung Cancer is the leading cause of cancer related death among men and women. M2 macrophages are known suppressors of host anti-tumor immune functions and promote primary growth and…
ISEF · 2018
Biomedical and Health Sciences
BACKGROUND: Peanut allergy therapies, such as EpiPens, treat anaphylactic reactions, but do not cure allergies. Previously, altering a monomicrobial microbiome with Bacteroides fragilis damp…
ISEF · 2018
Biomedical and Health Sciences
Type 2 Diabetes mellitus is a serious global health problem that is characterized by postprandial hyperglycemia. Presently, long-term use of commercial drugs in the management of diabetes ha…
ISEF · 2018
Translational Medical Science First Award
Heart disease is the leading cause of death worldwide (WHO), and experts estimate that half of all heart attacks and strokes occur in people who have not been flagged as ‘at risk'. There is…
ISEF · 2018
Translational Medical Science Fourth Award
Chemotherapy continues to play an important role in treating various cancers; however, during the course of treatment it is often challenging to differentiate between cancerous and healthy t…
ISEF · 2018
Translational Medical Science
Kyphosis is the excessive curvature of the thoracic spine along the sagittal plane, creating a hunchback or slouching appearance. It is a pressing issue in modern society due to anatomical i…