Browse real student projects, abstracts, and awards.
ISEF · 2024
Biomedical and Health Sciences Third Award
The prediction and optimization of drug solubility in various formulations play a pivotal role in drug development. Statins (STN), a widely prescribed cholesterol-lowering drug family, exhib…
ISEF · 2024
Translational Medical Science Fourth Award
I propose a method that enables the development of treatments for the 350 million people worldwide suffering from 7,000 rare genetic diseases. Genomic therapies for rare genetic diseases are…
ISEF · 2024
Biomedical and Health Sciences Fourth Award
Neuroinflammation in the hippocampus and hypothalamus constitutes the common pathology underlying various neurodegenerative diseases and metabolic syndrome, respectively. Environmental induc…
ISEF · 2024
Translational Medical Science Fourth Award
Neurofibromatosis 1 (NF1) is an autosomal dominant cancer predisposition syndrome that affects 1 in 3,000 individuals indiscriminately. It is primarily characterized by the growth of periphe…
ISEF · 2024
Biomedical and Health Sciences
For the past three years, I have been conducting research and experiments on several different antibiotic ointments and their effectiveness against different bacteria. This year, Neosporin a…
ISEF · 2024
Biomedical and Health Sciences
For decades, lung cancer has been the leading cause of cancerous deaths worldwide. Much of lung cancer's lethality is attributed to its high incidence of tumor relapse and drug resistance. I…
ISEF · 2024
Biomedical and Health Sciences
Lung cancer ranks as the third leading cause of deaths in the Philippines and a major global contributor to cancer-related mortality. It is recognized that several natural products have anti…
ISEF · 2024
Translational Medical Science
Resistance to antimalarial drugs has increased the mortality rate in malaria cases globally. Artemisinin-based Combination Therapies (ACTs) are the first-line malaria treatment worldwide by…
ISEF · 2024
Translational Medical Science
Bladder cancer is the fourth most common cancer among men, affecting more than 80,000 people in the United States every year. Cisplatin, a chemotherapy agent, is employed in the standard-of-…
ISEF · 2024
Biomedical and Health Sciences
Stroke is a severe neurological disease that affects many people around the world. Post-stroke dysphagia complications can lead to malnutrition, which further complicates the problem. Addres…
ISEF · 2024
Translational Medical Science
Based on data from the World Health Organization, in 2020, cancer accounted for 10 million deaths worldwide. Recent studies show promise in using specific metal nanoparticles to selectively…
ISEF · 2024
Biomedical and Health Sciences Fourth Award
This research study was performed to determine whether Ashwagandha can be used as an effective treatment for Inflammatory Bowel Disease (IBD) in Zebrafish embryo models. IBD is a chronic gas…
ISEF · 2024
Translational Medical Science
Coping with an abrasion or cut poses the challenge of not just averting bleeding but also managing blood contact while searching for and opening adhesive bandages strips like Band-Aids®. The…
ISEF · 2024
Biomedical and Health Sciences
Trigeminal neuralgia (TN) is an idiopathic pain disorder, classified by paroxysmal pain in the face. The spinal trigeminal tract extends into the spinal cord as far as the fourth cervical ve…
ISEF · 2024
Biomedical and Health Sciences
Alzheimer's Disease International (2024) predicts that by 2030, Alzheimer's will impact over 78 million people worldwide. Currently, there is no cure or accurate diagnostic method for Alzhei…
ISEF · 2024
Biomedical and Health Sciences
Handwriting is defined as a complex neurophysiological process that involves multiple aspects including visual-motor, memory, and linguistic aspects as well as multiple subsections of the ce…
ISEF · 2024
Translational Medical Science
The inability of deep learning (DL) models to explain their output, known as the AI “Black Box” problem, greatly hinders clinical adoption of DL models in healthcare. This study is the first…
ISEF · 2024
Biomedical and Health Sciences
Cancer is one of the major adverse health issues in the world, and is the second leading cause of death amongst Native Hawaiians. Ovarian cancer specifically, is known to have a stronger eff…
ISEF · 2024
Biomedical and Health Sciences
Introduction While the incidence of esophageal adenocarcinoma is rapidly increasing, the prognosis remains poor with a five-year survival rate of 20%. Therefore, the discovery of new molecul…
ISEF · 2024
Biomedical and Health Sciences
Chronic kidney disease (CKD) results in a progressive loss of kidney function over time, affecting 37 million in the US. Chymase is the primary enzyme mediating angiotensin II formation inde…
ISEF · 2024
Biomedical and Health Sciences
Over 1 million deaths annually can be attributed to suicide, yet no biomarkers exist. This study investigated blood-brain barrier (BBB) disruption by examining claudin-5 (CLDN5) epigenetic a…
ISEF · 2024
Translational Medical Science
Traumatic Brain Injury (TBI) is an intracranial damage common among soldiers and impact-sport athletes. In severe cases, TBI is associated with neurodegeneration and dementia if left untreat…
ISEF · 2024
Biomedical and Health Sciences
Chimeric Antigen Receptor (CAR) T cells and Bispecific T cell Engagers (BiTEs) are two novel immunotherapy platforms. I hypothesized that the different mechanisms used by anti-CD3-CD19 BiTEs…
ISEF · 2024
Translational Medical Science
Duchenne Muscular Dystrophy (DMD) is an inherited X-linked disease with an incidence of 1:3,600. Patients become weak at 2-3 years old with progression to a wheelchair in their early teens,…
ISEF · 2024
Biomedical and Health Sciences
Glioblastoma Multiforme (GBM) is an aggressive and fast-growing form of brain cancer with a high rate of mortality. It is the most common malignant brain tumor in adults, accounting for 47.7…
ISEF · 2024
Biomedical and Health Sciences
Systemic sclerosis (SSc) is an autoimmune disease with multiple organ involvement, including lung, skin, gastrointestinal tract, and kidneys. A subset of SSc patients develops a critical ren…
ISEF · 2024
Biomedical and Health Sciences
Facioscapulohumeral muscular dystrophy (FSHD) is a genetic, progressive myopathy and the second most common muscular dystrophy. Progression of the disease primarily begins in the facial, sho…
ISEF · 2024
Translational Medical Science
The visual similarity of melanoma and seborrheic keratosis has made it difficult for elderly patients with disabilities to know when to seek medical attention, contributing to the metastasis…
ISEF · 2024
Biomedical and Health Sciences Third Award
Circadian disruptions have been implicated in the oncogenesis of multiple cancers. However, the underlying mechanisms linking circadian rhythms and cell cycles remain unclear, posing a signi…
ISEF · 2024
Translational Medical Science Second Award
Inflammatory Bowel Disease (IBD) is a prevalent autoimmune condition that affects 2.39 million Americans and is characterized by an excess of inflammatory cytokines. Interleukins, a class of…