Browse real student projects, abstracts, and awards.
ISEF · 2025
Translational Medical Science
Stroke is a leading cause of both morbidity and long-term disability. Timely and accurate detection is critical, as ischemic stroke (IS), caused by blood clots blocking brain circulation, an…
ISEF · 2025
Biomedical and Health Sciences
Botulinum neurotoxin type A (BoNT/A) represents a serious biological threat to global public health due to its extreme toxicity and its prolonged persistence. Recently, several camelid singl…
ISEF · 2025
Translational Medical Science
Diabetic Retinopathy (DR) is a serious complication associated with diabetes that can lead to vision loss in middle-aged and older adults. Caused by chronic high blood sugar levels, poor gly…
ISEF · 2025
Biomedical and Health Sciences
Cardiac complications associated with SARS-CoV-2 infection include arrhythmias, myocarditis, and heart failure. However, the pathogenesis underlying COVID-19-induced cardiac dysfunction rema…
ISEF · 2025
Biomedical and Health Sciences
COVID-19, caused by SARS-CoV-2, has been associated with a range of cardiovascular complications, including arrhythmias and cardiomyopathy. This study investigates how the SARS-CoV-2 spike p…
ISEF · 2025
Translational Medical Science
Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder affecting millions of women worldwide. It is characterized by irregular periods, alopecia, hyperandrogenism, infertility, hirsutis…
ISEF · 2025
Biomedical and Health Sciences
Triple-negative breast cancer (TNBC) is a subtype of breast cancer which has none of the known unique biomarkers of the other subtypes. There is no established targeted treatment for TNBC an…
ISEF · 2025
Biomedical and Health Sciences
Individuals with conditions like "lazy eye," amblyopia, and strabismus have been experiencing issues with peripheral vision. This study aims to test if VR use in gaming can improve periphera…
ISEF · 2025
Biomedical and Health Sciences
Cancer is the second leading cause of death in the US. Among the various forms of cancer, breast cancer and lung cancer are particularly significant due to their prevalence and impact. Breas…
ISEF · 2025
Biomedical and Health Sciences
Affecting approximately one in every 1000 babies born in the U.S., congenital hydrocephalus (CH) is the abnormal build-up of cerebrospinal fluid (CSF) in the ventricles of the brain. CH resu…
ISEF · 2025
Translational Medical Science
Cancer remains one of the most significant global health challenges, with the c-MYC proto-oncogene implicated in over 50% of cases, particularly in solid tumors. When dysregulated, c-MYC pro…
ISEF · 2025
Translational Medical Science
Histone Lysine Demethylase 4 (KDM4) and Mammalian Bromodomain and Extra-Terminal Domain (BET) are proteins that are highly dysregulated in multiple kinds of cancers. This study researched th…
ISEF · 2025
Biomedical and Health Sciences
Cancer has remained the leading cause of death globally, with the mutation of the Tumor Suppressor Gene TP53 via DNMT1 methylation occurring in 50% of cases. Current epigenetic therapies mis…
ISEF · 2025
Biomedical and Health Sciences
Pulmonary hypertension (PH) is a pulmonary vascular disease exhibiting a high mean arterial pressure (25mmHg at rest). Cellular hyperproliferation contributes to vascular remodeling, leading…
ISEF · 2025
Biomedical and Health Sciences
Short-read RNA sequencing is limited by its inability to fully sequence long genetic transcripts, requiring computational reconstruction that often hinders accurate characterization of trans…
ISEF · 2025
Translational Medical Science
Background: Pancreatic Ductal Adenocarcinoma (PDAC) is the most common form of pancreatic cancer, a cancer with only a 12%-five-year survival rate. PDAC relies on the Human antigen RNA bindi…
ISEF · 2025
Translational Medical Science
Cancer is currently the second leading cause of death in the world. There are several treatments available, but most have side effects or are highly expensive. Therefore, it is necessary to…
ISEF · 2025
Biomedical and Health Sciences
Nicotine is a highly addictive drug that has been found to disrupt gamma aminobutyric acid (GABA) neuron migration in the developing cerebral cortex. This project investigates if GABA neuron…
ISEF · 2025
Translational Medical Science
Leukemia, a cancer of blood-forming tissues, is the 10th most common cancer. This study focused on the impact that cannabinoids (CBD) and nicotine had on the growth rate of K562 cell lines.…
ISEF · 2025
Biomedical and Health Sciences
Sleep is a critical physiological process necessary for cognitive function, emotional stability, and brain health. However, both acute and chronic sleep deprivation significantly impair brai…
ISEF · 2025
Biomedical and Health Sciences
Pediatric sarcomas comprise approximately 10% of childhood solid tumors, with metastatic disease yielding survival rates as low as 20-25%. Despite many efforts, advancements in survival outc…
ISEF · 2025
Translational Medical Science
Background: Parkinson’s disease (PD) is a neurodegenerative disease caused by degeneration of dopaminergic neurons due to alpha-synuclein (AS) aggregation. Microbiome dysbiosis has been reco…
ISEF · 2025
Biomedical and Health Sciences
This study aims to understand how the increase in pH levels within the stomach, caused by a condition called Hypochlorhydria, contribute to a decrease in the ability to digest food and absor…
ISEF · 2025
Biomedical and Health Sciences
The use of antibiotics to inhibit breast cancer cell proliferation is a novel approach to cancer treatment. Antibiotics, such as gentamicin and chloramphenicol, primarily known for their ant…
ISEF · 2025
Biomedical and Health Sciences
The purpose of this project was to determine if increased hypohydration of a sheep brain is directly correlated with brain tissue damage after exposure to a concussion-inducing force. The hy…
ISEF · 2025
Translational Medical Science
Multiple Myeloma is a type of hematologic cancer that often significantly affects people's lives; therefore, this scientific research was created with the objective of studying the relations…
ISEF · 2025
Biomedical and Health Sciences
Gastric adenocarcinoma is the fourth most common type of cancer in Brazil, often diagnosed at advanced stages, when the cure rate drops to 30%. MicroRNAs (miRNAs) are essential post-transcri…
ISEF · 2025
Biomedical and Health Sciences
Bacterial cellulose (BC) is a promising biomaterial for wound healing and regenerative medicine due to its biocompatibility, water retention, and high tensile strength. This study evaluates…
ISEF · 2025
Biomedical and Health Sciences
Iron-sulfur (Fe-S) clusters are cell-essential cofactors present in roughly 60 proteins, including DNA polymerases, subunits of oxidative phosphorylation complexes, and iron-sensing proteins…
ISEF · 2025
Biomedical and Health Sciences
Hypermobile Ehlers-Danlos Syndrome (hEDS) is an inherited connective tissue disorder that primarily stems from defects in the extracellular matrix, namely collagen. Within those diagnosed, f…