Browse real student projects, abstracts, and awards.
ISEF · 2019
Cellular and Molecular Biology
Norepinephrine (NE) and acetylcholine (ACh) mediate cell-to-cell communication in the central and peripheral nervous systems. Due to their importance in regulating many complex brain functio…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Aggregation of protein tau into neurofibrillary tangles and a-synuclein into Lewy bodies are hallmarks of Alzheimer’s and Parkinson’s disease, respectively. These proteins are known to form…
ISEF · 2019
Cellular and Molecular Biology
CRISPR is a rising gene editing technique that, although unprecedented in medical applications, has been found to cause unintentional edits that have fatal effects on an organism. In order t…
ISEF · 2019
Cellular and Molecular Biology
Arsenite contamination of source water presents a threat to dozens of developing countries that cannot afford remediatory solutions. The conversion of arsenite to arsenate via oxidation pres…
ISEF · 2019
Cellular and Molecular Biology
The extent of cell to cell communication between macrophages and tumor melanoma cells in mice was investigated. Two experiments were run. The first was an MTT assay which investigated whethe…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Abscission, the final stage of cytokinesis, is characterized by the separation of cells through the severing of the intercellular bridge at the midbody. Components of the Endosomal Sorting C…
ISEF · 2019
Cellular and Molecular Biology
Hydroxyurea (HU) is a ribonucleotide reductase inhibitor which is used to treat diseases such as HIV, sickle cell disease, and chronic myelogenous leukemia (1). Yet, new evidence suggests th…
ISEF · 2019
Cellular and Molecular Biology
Slime molds are single-celled organisms that combine interesting properties. We tested this organism’s reaction to a basic and anacidic environment. The slime mold Physarum polycephalum was…
ISEF · 2019
Cellular and Molecular Biology
Memory CD8 T cells are immune cells that eliminate diseased cells in the body. Recent approaches to treating chronic illnesses involve bolstering their immune responses to target abnormal ce…
ISEF · 2019
Cellular and Molecular Biology
The mountain lion (Puma concolor) is a large felid endemic to North and South America. Mountain lions were nearly extirpated across much of their range due to anthropogenic encroachment, hab…
ISEF · 2019
Cellular and Molecular Biology Third Award
Pancreatic adenocarcinoma(PDA) is one of the most malignant tumors, with an estimated 50,000 diagnoses and deaths per year. Current therapies have little effect on PDA due to the tumor’s lar…
ISEF · 2019
Cellular and Molecular Biology
Approximately 40% of the human genome is comprised of retrotransposons, which are genetic elements capable of amplifying themselves within the genome. Throughout the course of human life, re…
ISEF · 2019
Cellular and Molecular Biology Third Award
The challenge of finding the HIV cure lies in latent HIV-infected cells, which are inert to current HIV treatment. Since CD32a has been identified as a potential biomarker of latent HIV-infe…
ISEF · 2019
Cellular and Molecular Biology
The purpose of this research is to investigate which genetic mutations are responsible for Uveal Melanoma (UM), a rare subtype of melanoma but the most frequent primary cancer of the eye. Ge…
ISEF · 2019
Cellular and Molecular Biology
BACKGROUND: The androgen receptor (AR) is the driving force of prostate cancer growth. The AR is a nuclear receptor which, upon activation, goes to the nucleus and promotes transcription of…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Therapeutic targets for Ankylosing Spondylitis (AS) pathology are non-specific, and the cellular mechanisms that drive tissue proliferation in AS are poorly understood. This study investigat…
ISEF · 2019
Cellular and Molecular Biology Third Award
The enzyme Fidgetin-like 2 (FL2) suppresses cell migration by severing intracellular filaments called microtubules (MTs). Mouse studies showed that depleting FL2 using small interfering RNA…
ISEF · 2019
Cellular and Molecular Biology
Background: Traditional chemical-based treatments for disease are non-specific and cause undesirable side effects. These non-target effects can be avoided by site-specific, targeted therapy…
ISEF · 2019
Cellular and Molecular Biology Third Award
Gefitinib, which is a small molecule tyrosine kinase inhibitor (TKI) of epithelial growth factor receptor (EGFR), is currently under investigation for colon cancer treatment. However, some p…
ISEF · 2019
Cellular and Molecular Biology
This study examines epigenetic therapy as a treatment for slowing the growth of cancerous liver cells. More specifically, epigenetic changes such as the abnormal patterning of DNA hypo- and…
ISEF · 2019
Cellular and Molecular Biology
This experiment was designed not only from a continuation of a previous year, but as well as an improvement. Essential oils were present to prove that they have special and unique properties…
ISEF · 2019
Cellular and Molecular Biology
Angiogenesis is requisite for the growth and metastatic spread of solid tumors. Identifying pathological angiogenesis regulators will provide therapeutic targets against solid tumor growth.…
ISEF · 2019
Cellular and Molecular Biology
Currently, mutations in the BRCA1 and 2 genes are estimated to explain approximately 15 percent of hereditary breast cancer cases. However, studies have established that 50 percent of women…
ISEF · 2019
Cellular and Molecular Biology
Gastric cancer is one of the most common causes of cancer related deaths, yet little is known about the molecular drivers behind the progression of normal stomach to gastric cancer. GATA4 an…
ISEF · 2019
Cellular and Molecular Biology
Inhibitor of DNA binding 2, or Id2, is a protein that is required for hematopoietic stem cell (HSC) maintenance and self-renewal capacity. A positive feedback loop has been identified involv…
ISEF · 2019
Cellular and Molecular Biology
Over 70% of breast cancer patients’ cells express the estrogen receptor (ER), which promotes the proliferation of cancer cells, by activating the expression of tumor-promoting genes. In the…
ISEF · 2019
Cellular and Molecular Biology
Probiotic bacteria have been intensively studied for their role in the gut microbiome and digestion. Research into the abilities of probiotic bacteria to fight pathogens is also a growing ar…
ISEF · 2019
Cellular and Molecular Biology
Alzheimer’s is a progressive neurological disorder that affects memory and is the third leading cause of death. Downregulation of apolipoprotein E (ApoE) gene is involved in late-onset Alzhe…
ISEF · 2019
Cellular and Molecular Biology Third Award
Worldwide, stroke is the second leading cause of death and the third leading cause of disability. There is a striking lack of therapeutic interventions after the first few hours of stroke on…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Schizophrenia is a debilitating neurological disorder characterized by hallucinations, paranoia, and delusions. Identifying how schizophrenia specifically causes changes in the structure and…