38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2023
Cellular and Molecular Biology
Paxillin is a known regulator of focal adhesions and actin cytoskeleton dynamics, crucial for cell migration. However, our study discovered a novel function of paxillin in neurons. We found…
ISEF · 2023
Cellular and Molecular Biology
Purpose: Though the behavioral effects of transcranial direct current stimulation (tDCS) are well-documented, a gap exists in current literature on its effects on glymphatic system dynamics…
ISEF · 2023
Cellular and Molecular Biology
This study aimed to determine if Drosophila melanogaster PFK (DmPFK) forms filaments, and if so, under what conditions. Enzyme filamentation, or the reversible formation of oligomers, has be…
CSEF · 2023
Biochemistry/ Molecular Biology Honorable_mention Award
Glioblastoma (GBM) is the most common malignant adult brain tumor. With minimal clinical innovation, the prognosis for GBM patients remains grim. However, there is a commonality between 83%…
CSEF · 2023
Biochemistry/ Molecular Biology Fourth Award
Cancer is the second highest cause of death in the U.S. per year. Cannabidiol, CBD, is a phytocannabinoid found in the plant cannabis sativa and could have properties helping against cancer.…
ISEF · 2023
Cellular and Molecular Biology
Acod1 is a gene that codes for immune response gene 1 (IRG1), an enzyme that converts TCA cycle intermediate cis-aconitate into itaconate. Itaconate exerts multiple biological effects, from…
ISEF · 2023
Cellular and Molecular Biology Second Award
Type 2 Diabetes (T2D) affects millions worldwide but has an exceptionally high prevalence in Hawaii, with a rate of 9% for all residents aged 18 or older. Of that 9%, 13.1% are Native Hawaii…
CSEF · 2023
Biochemistry/ Molecular Biology (Senior Division)
Background: Aging-associated oxidative stress and free radical generation leads to collagen degradation and subsequent reduced skin elasticity, bone degeneration and organ dysfunction. Omega…
ISEF · 2023
Cellular and Molecular Biology
Proper cellular morphology and plasma membrane structure during interphase are integral for proper mitosis and homeostasis. Tumor suppressor PTEN (Phosphatase and TENsin homologue deleted on…
ISEF · 2023
Cellular and Molecular Biology Third Award
Current research is focused on identifying drugs that can mitigate chemotherapy-induced injury to normal tissues, while being cytotoxic to cancer cells. This study was designed to evaluate t…
ISEF · 2023
Cellular and Molecular Biology
A class of type II diabetes medication interacts with a nuclear receptor known as PPAR?. While these drugs are effective at managing type II diabetes, however, they have dangerous side effec…
ISEF · 2023
Cellular and Molecular Biology Second Award
As mRNA-based therapeutics like COVID-19 vaccines rapidly evolve, degradation remains a key limiter of efficacy and distribution. Circular RNAs (circRNAs) possess a closed-loop structure, co…
CSEF · 2023
Biochemistry/ Molecular Biology First Award
As mRNA-based therapeutics like COVID-19 vaccines rapidly evolve, degradation remains a key limitation. Circular RNAs (circRNAs) possess a closed-loop structure, conferring enhanced stabilit…
CSEF · 2023
Biochemistry/ Molecular Biology Third Award
Ethanol is a renewable, domestically produced transportation fuel. Overall, the transportation sector accounts for approximately 30% of total U.S. energy needs and 70% of U.S. petroleum cons…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
Pancreatic cancer is among the world's deadliest cancers with a 5-year survival rate below 9%. Pancreatic ductal adenocarcinoma (PDAC) encompasses >90% of all pancreatic cancers, and >95% ar…
ISEF · 2023
Cellular and Molecular Biology Third Award
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are two types of hematologic malignancies with especially poor prognoses and limited therapeutic options. Notably, mutations i…
ISEF · 2023
Cellular and Molecular Biology Third Award
Recent changes in climate, increased energy production, overpopulation, and inadequate water use and infrastructure led to freshwater shortage globally. There is an urgent need to develop ne…
ISEF · 2023
Cellular and Molecular Biology Third Award
The NMDA receptor (NMDAR) plays an integral role in neuronal communication and neurodevelopment, and its malfunction has been linked to multiple neurodevelopmental diseases (NDDs) including…
ISEF · 2023
Cellular and Molecular Biology
The signaling between the gastrointestinal (GI) tract and the brain is incredibly important, as it manages multiple processes, including hunger rates. This signaling impacts eating patterns…
ISEF · 2023
Cellular and Molecular Biology
Facioscapulohumeral Muscular Dystrophy is one of the most common muscular dystrophies within the United States. However, very little research has been conducted in comparison to other dystro…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer with a lack of effective treatment options and high rates of metastasis. Angiogenesis, the formation of new…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
The COVID-19 pandemic due to the SARS-CoV-2 virus threatens global public health. The immune response in patients plays a significant role in resisting COVID-19 infection, one part of which…
ISEF · 2023
Cellular and Molecular Biology
Natural Killer (NK) cells -both circulating (cNK) and liver resident (lr-NK) - are a major component of innate host defense against Hepatocellular carcinoma (HCC). NK cell dysfunction is ass…
ISEF · 2023
Cellular and Molecular Biology
FBW7 is a substrate recognition component and a tumor suppressor in the E3 ligase complex. It plays a major role in combating oncoproteins and regulating different types of cancers, most not…
CSEF · 2023
Biochemistry/ Molecular Biology Third Award
Better therapeutics for prostate cancer are needed because over 34,000 American men are estimated to die of prostate cancer in 2022. Natural products have been a valuable source of anticance…
CSEF · 2023
Biochemistry/ Molecular Biology First Award
Mental health in teenagers is an important topic which we want to raise awareness on. We analyzed two aspects which can potentially impact it - genetic and non-genetic. For both genetic and…
CSEF · 2023
Biochemistry/ Molecular Biology Honorable_mention Award
Childhood obesity and diabetes are on the rise in the United States and some of its major contributors are inactive lifestyles and unhealthy diets. There are hidden sugars in common foods th…
AJAS · 2022
Cellular Science
Parkinson’s Disease (PD), a neurodegenerative disorder, is caused by the death of dopaminergic neurons in the substantia nigra. Caffeine exposure is suggested to mitigate the PD onset and pr…
ISEF · 2022
Cellular and Molecular Biology Fourth Award
Glioblastoma Multiforme (GBM) is a type of malignant brain tumor and it is the most lethal with a median survival of only 21 months. It is characterized by an extremely strong recurrence rat…
ISEF · 2022
Cellular and Molecular Biology
Staphylococcus aureus bacteria is the world’s leading cause of bone implant infection causing osteomyelitis. Osteomyelitis accounts for half of all chronic diseases in people over 50 and thi…