38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division) Honorable_mention Award
Focal Cortical Dysplasia (FCD) causes epilepsy in 4 million newborns yearly. Treatments are surgical removal of malformed brain tissue, which fails for 40% of patients and causes permanent c…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division) Honorable_mention Award
Microbial Fuel Cells (MFCs) are a promising technology that generate electricity through the metabolic processes of bacteria such as Geobacter and Shewanella. These bacteria release electron…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
The purpose of my project is to find which fruit has the most sugar by measuring it with a refractometer (Sugar Brix). All ripe fruits that I used for my experiment are pineapple,grapes, gol…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
The purpose of this project was to determine whether the nutritional value of eggs varies based on their source. Samples were collected from backyard chicken eggs, as well as a range of comm…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
α-synuclein aggregation is a hallmark of Parkinsonian disorders, where the normally flexible protein misfolds into β-sheet–rich fibrils that disrupt cells. Despite its importance, the specif…
ISEF · 2025
Cellular and Molecular Biology
Cortical interneurons (INs) are a diverse group of INs crucial for regulating excitatory pyramidal neuron (EPN) activity– with dysfunction in certain IN types linked to neurological disorder…
ISEF · 2025
Cellular and Molecular Biology Second Award
Neurodegenerative diseases (NDDs), like Alzheimer's and Parkinson's, are characterized by impairment of synaptic plasticity, the brain's capacity to rewire connections critical for cognition…
ISEF · 2025
Cellular and Molecular Biology Fourth Award
Metastatic prostate cancer (mPC) stands second in cancer-related mortality among men. As current treatment options are largely palliative, there is a dire need for novel therapeutic targets…
ISEF · 2025
Cellular and Molecular Biology
Translation initiation in human embryonic stem cells (hESCs) is governed by a delicate balance among canonical, cap-dependent and alternative pathways. This study dissects the roles of eIF4G…
ISEF · 2025
Cellular and Molecular Biology
Uveal melanoma, cancer of the melanin-producing cells in the eye, is the most common type of intraocular cancer in adults. Approximately half the patients develop metastatic disease, which h…
ISEF · 2025
Cellular and Molecular Biology
Glioblastoma multiforme (GBM) is one of the most aggressive and prevalent malignant primary brain tumors, accounting for 50.1% of all gliomas and 16% of all primary brain tumors. In the Unit…
AJAS · 2025
Cellular and Molecular Biology (inferred)
In a recent study, 33% of individuals with neurodevelopmental disorders (NDDs) carried mutations in ASXL3, whose function is unknown. To understand ASXL3’s role in NDDs, we used CRISPR tec…
ISEF · 2025
Cellular and Molecular Biology Third Award
Neurodevelopmental disorders (NDDs) affect over 300 million people globally. In previous research, we identified ASXL3 as a biomarker for NDDs, but our understanding of how the clinical seve…
ISEF · 2025
Cellular and Molecular Biology
This project aimed to focus on identifying VEGF-B’s specific roles in cell survival and apoptosis, as well as its role in-vivo in cardiomyocyte regeneration within the zebrafish heart. The f…
ISEF · 2025
Cellular and Molecular Biology Second Award
Myasthenia gravis (MG) is a debilitating autoimmune disease of the neuromuscular junction that affects over a million people and can cause life-threatening muscle weakness. As current treatm…
ISEF · 2025
Cellular and Molecular Biology
Helicases are enzymes that unwind double-stranded DNA during replication and repair. Human DNA helicase B (HELB) is critical for proper genome maintenance and recovery from replication stres…
ISEF · 2025
Cellular and Molecular Biology
Neurons use neurotransmitter carrying synaptic vesicles to transmit information at specialized locations called presynapses. Synaptic vesicle release of neurotransmitter becomes less efficie…
ISEF · 2025
Cellular and Molecular Biology
Cancer is the second leading cause of death worldwide. In 2021 almost 10 million people died of cancer. Numerous conditions and factors can be attributed to the formation of cancer. A critic…
ISEF · 2025
Cellular and Molecular Biology Fourth Award
Base editors hold great promise in the treatment of genetic diseases as nearly half of known pathogenic genetic variants are point mutations. However, despite recent progress, the base edito…
ISEF · 2025
Cellular and Molecular Biology Third Award
Fibrodysplasia Ossificans Progressiva (FOP) is a rare bone disorder caused by a mutation in the ACVR1 receptor, whose downstream signaling leads to excessive bone growth. The defining charac…
ISEF · 2025
Cellular and Molecular Biology Third Award
Fetal Bovine Serum (FBS) is a staple supplement in cell culture, providing key growth factors that promote cell health and proliferation. Cell culture has been a cornerstone of biological sc…
ISEF · 2025
Cellular and Molecular Biology Fourth Award
Alcohol consumption leads to complications in brain blood vessels and biological function, but how alcohol damages such vessels is unclear. Lysophosphatidic acid (LPA) signaling, regulated b…
ISEF · 2025
Cellular and Molecular Biology
Although CAR T-cell therapy has significantly improved treatment outcomes for hematologic B-cell malignancies, challenges such as relapse and mortality rates (35-50% within 6-12 months post-…
ISEF · 2025
Cellular and Molecular Biology
Epigenetics is the study of how environmental stimuli affect gene expression without altering the DNA sequence. DNA methylation is an epigenetic mechanism in which a 5-methyl group binds to…
ISEF · 2025
Cellular and Molecular Biology
Sorafenib, a targeted anticancer therapy, is used in the treatment of advanced renal cell carcinoma by inhibiting vascular endothelial growth factor receptors (VEGFRs) and tyrosine kinases (…
ISEF · 2025
Cellular and Molecular Biology
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite that persistently infects the central nervous system (CNS) of up to a third of the world’s population. In the immune compe…
ISEF · 2025
Cellular and Molecular Biology
Research showed significant changes in the brain of Drosophila melanogaster such as fewer stem cells and smaller brains after knocking out nhes in the brain. Nhes also affect a decline in ag…
ISEF · 2025
Cellular and Molecular Biology
The endothelium, a layer of cells lining the inner wall of coronary arteries, contributes to blood hemostasis and healthy function of the heart. In coronary artery disease (CAD), endothelial…
ISEF · 2025
Cellular and Molecular Biology Fourth Award
Epidemiological studies performed in large cohorts among different populations indicate a negative correlation between developing melanoma skin cancer and drinking coffee. While coffee’s pop…
ISEF · 2025
Cellular and Molecular Biology
Constituting up to 90% of tumor volume in pancreatic ductal adenocarcinoma (PDAC), fibrotic tissue growth (desmoplasia) acts to inhibit chemotherapeutic drug delivery through physical blocka…