Browse real student projects, abstracts, and awards.
ISEF · 2017
Cellular and Molecular Biology
The purpose of this experiment was to identify molecular mechanisms involved with the regulation of the MAPT gene and the subsequent formation of neurofibrillary tangles in Alzheimer’s disea…
ISEF · 2017
Cellular and Molecular Biology Third Award
Every minute, a woman somewhere in the world will die of breast cancer. Despite significant advances in the field, breast cancer remains the leading cause of cancer death in women globally.…
ISEF · 2017
Cellular and Molecular Biology Third Award
Vaccines are the one of greatest health innovations in human history, saving an estimated two million lives annually. They function by exposing the body to an antigen mimicking a pathogen an…
ISEF · 2017
Cellular and Molecular Biology
Although studies have found that inorganic arsenic (iAs), a potent carcinogen and estrogen-mimicking endocrine disruptor, is directly associated with prostate cancer incidence and mortality,…
ISEF · 2017
Cellular and Molecular Biology
Infantile spasms (IS) is a neurological condition that generally initiates development of more severe forms of epilepsy along with developmental disabilities. An investigation of the role pl…
ISEF · 2017
Cellular and Molecular Biology Third Award
Metastasis accounts for ~90% of deaths from breast cancer (BC). This study aims to address the fundamental question of how cancer cells in the primary breast tumor become metastatic. CHD7 is…
ISEF · 2017
Cellular and Molecular Biology
Astrocytes, the most abundant cell type in the central nervous system (CNS), have the vital role of keeping homeostasis in the brain. HIV infects the CNS early after primary infection and ca…
ISEF · 2017
Cellular and Molecular Biology
Circular RNAs (circRNAs) constitute a class of relatively unstudied RNAs whose function is unknown. Recently, studies have shown that circRNAs are more abundant than previously recorded. The…
ISEF · 2017
Cellular and Molecular Biology Second Award
Genome editing technologies have revolutionized our ability to integrate foreign DNA sequences into cells with single nucleotide resolution. A major bottleneck of genome editing today is the…
ISEF · 2017
Cellular and Molecular Biology
Overlapping polymerase chain reaction (O-PCR) is a common technique used in diverse fields to 'stitch' individual strands of DNA together. Previously, STITCHER was created to automate primer…
ISEF · 2017
Cellular and Molecular Biology First Award
It is evident that the tongue perceives tactile sensation, but little is known about the neurons that mediate this. Since tropomyosin receptor kinase C (TrkC) neurons are mechanoreceptors on…
ISEF · 2017
Cellular and Molecular Biology
Chromosome movements during mitosis are orchestrated primarily by the interaction of spindle microtubules with the kinetochore, the site for attachment of spindle microtubules to the centrom…
ISEF · 2017
Cellular and Molecular Biology
The purpose of this experiment is to see if changing the chemical structure of Methylbutenol (MBO) synthase’s active site from a Phenylalanine to a Tyrosine will effect the production of MBO…
ISEF · 2017
Cellular and Molecular Biology
Tissues in our body experience a variety of mechanical stimuli that are important in physiological and pathophysiological conditions. Compression can arise from cells in the stiff micro envi…
ISEF · 2017
Cellular and Molecular Biology
The purpose of my project was to determine if administering tocotrienol with a form of chemotherapy will induce apoptosis at a faster rate. The way I conducted this experiment was that I acq…
ISEF · 2017
Cellular and Molecular Biology
Type 2 diabetes rates are on the rise due to changing lifestyles. Diabetes can cause hyperglycemic events, which can damage cells. However, how hyperglycemic damage occurs is not completely…
ISEF · 2017
Cellular and Molecular Biology
Western diet has been linked with health issues, such as obesity and Alzheimer’s disease. It is vital to understand the mechanisms in which diet affects the brain in order to identify therap…
ISEF · 2017
Cellular and Molecular Biology
G protein coupled receptors (GPCR’s) are the largest family of membrane bound receptors. They are characterized by seven transmembrane helices. NBA1, a generic gene identifier, will be used…
ISEF · 2017
Cellular and Molecular Biology
Harnessing the immune system to attack cancer is a novel treatment called immunotherapy. It uses antibodies to block signaling pathways that deactivate T cells. These inhibitory pathways exi…
ISEF · 2017
Cellular and Molecular Biology
Neuroblastoma is a lethal and commonly metastatic childhood cancer that arises when neural crest cells fail to differentiate properly during embryonic development. A group of cell-signaling…
ISEF · 2017
Cellular and Molecular Biology
Imatinib is a drug commonly used for the treatment of BCR-ABL1-positive leukemia. However, imatinib-resistant cells often develop after treatment, causing therapeutic failure. My previous re…
ISEF · 2017
Cellular and Molecular Biology
Angiogenesis, the formation of new blood vessels, is key in wound healing, embryonic development, and survival of cancerous tumors. Vascular Endothelial Growth Factor (VEGF) and its binding…
ISEF · 2017
Cellular and Molecular Biology
There is a need for a clinical alternative for the "gold standard" autograft. An autograft involves harvesting tissue from alternate locations in the body and substituting tissue in lacking…
ISEF · 2017
Cellular and Molecular Biology
Genome sequencing, the future of bacterial medicine. My name is Josh Proehl and I used genome sequencing to find a natural probiotic to replace the use of low dose growth antibiotics in turk…
ISEF · 2017
Cellular and Molecular Biology
Platelet endocytosis is very important, especially for fibrinogen uptake. Platelets contain several integral membrane proteins called soluble N-ethylmaleimide-sensitive factor Attachment Pro…
ISEF · 2014
Cellular and Molecular Biology
Insects are known to be able to warm their bodies endogenously and to regulate their body temperatures by themselves. However precise mechanisms of their body temperature regulations are not…
ISEF · 2014
Cellular and Molecular Biology
Dermatitis due to scabies is a common skin disease in cattle. Dermatitis causes economical loss in terms of abrogated levels of milk, meat and hides production. Available drugs are either ch…
ISEF · 2014
Cellular and Molecular Biology
Since 2002, the total retail price of United States beef has risen to over 25 billion dollars per year. The average feedyard cost to raise beef cattle has also increased to $494 per head. Wi…
ISEF · 2014
Cellular and Molecular Biology
The way the project is now focuses on which puzzle solving approaches different ages use primarily. The project started out with the intention to measure the effectiveness of each approach,…
ISEF · 2014
Cellular and Molecular Biology
Euglena, a phytomastigophora, moves either with its flagellum beating vigorously or with its body surface crooking and twisting. The latter movement, known as euglenoid movement, is frequent…