Biochemistry
Second Award
Ionizable lipid nanoparticles (LNPs) are the mainstream delivery mechanisms for mRNA vaccines, with their pH-sensitive protonation facilitating post-endocytic endosomal escape. However, LNPs…
Software Design
Second Award
Gaze keyboards require people with ALS to spell words one letter at a time, a process that is slow, exhausting, and forces users to translate simple thoughts into tedious typing sequences. E…
Plant Sciences
Second Award
Whether plants—which lack a nervous system—can exhibit "intelligent" behaviors such as learning and stimulus discrimination remains a fundamental question in biology. I addressed this questi…
Energy: Sustainable Materials and Design
Second Award
Solar water evaporation (SWE) outstands as a promising method to solve the global freshwater shortage due to its lower cost, green and sustainable. Semiconductors photothermal materials (SPM…
Biomedical and Health Sciences
Second Award
Chemoresistance remains a primary cause of cancer treatment failure and is increasingly attributed to non-genetic regulatory mechanisms. Emerging evidence suggests that three-dimensional chr…
Applied Mechanics (Junior Division)
Second Award
Mind Your Meds: A Timed Pill Dispenser Elijah Alcheck and Caden Eaton Objective/Goal: The goal of our project is a timed pill dispenser for seniors. Many seniors have trouble remembering to…
Biomedical and Health Sciences
Second Award
Food allergy (FA) affects 18% of the population and is driven by type-2 inflammation, epithelial barrier dysfunction, and tight junction (TJ) disruption. Recent studies identify Zonulin and…
Animal Sciences
Second Award
Pygmy and dwarf sperm whales (Kogia breviceps and Kogia sima) are deep-diving cetaceans with limited internal health data due to low visibility. Necropsies often reveal stomach infestations…
Robotics and Intelligent Machines
Second Award
Globally, tens of millions of people suffer from lower body impairments, including spinal cord injuries, cerebral palsy, stroke, and muscular dystrophies, leading to loss of independent mobi…
Microbiology
Second Award
An estimated $6 billion USD will be lost in 2026 globally due to disease outbreaks in aquaculture facilities, particularly from Vibrio coralliilyticus, a pathogen that infects corals, fish a…
Engineering Technology: Statics & Dynamics
Second Award
Autonomous vehicle (AV) research has focused on structured, high-income Western environments, leaving dense, variable developing regions underexplored. This project develops three prototypes…
Zoology (Junior Division)
Second Award
The goal of this experiment was to observe the effect that different extreme conditions had on the speed and mobility of Hypsibius exemplaris, an animal from a species of microscopic inverte…
Materials Science
Second Award
Despite decades of medical advancement, cancer continues to claim about 10 million lives annually. mRNA therapeutics represent a promising approach for cancer immunotherapy, particularly bec…
Physics and Astronomy
Second Award
Prior to the first unambiguous discovery in 2011, circumbinary planets (CBPs), planets orbiting two stars or eclipsing binaries (EBs), were considered unlikely to exist due to the perturbati…
Materials Science
Second Award
This study optimizes the composition and factors of potassium superoxide (KO2) and calcium hydroxide (Ca(OH)2) for use in a chemical oxygen generator (COG) for emergency escape devices. The…
Earth and Environmental Sciences
Second Award
Because exact earthquake prediction remains unavailable and retrofit budgets are limited, I developed a physics-anchored continuous space-time model to rank where short-term regional seismic…
Alternative Energy (Junior Division)
Second Award
This project examines the effectiveness of a propeller-based energy harvesting system on a boat in mitigating the impact of waves while harvesting low-velocity, oscillatory water motion. Exi…
Microbiology (Senior Division)
Second Award
Azole antifungals have long served as frontline therapies for Candida infections due to their efficacy and oral bioavailability. However, the increasing prevalence of azole- resistant Candid…
Biochemistry/ Molecular Biology (Senior Division)
Second Award
Rapid identification of respiratory pathogens is essential for selecting the appropriate treatment, especially in primary care clinics and developing areas with limited medical resources. I…
Engineering Technology: Statics & Dynamics
Second Award
Entanglement is the leading cause of death in marine mammals each year and it is estimated that only 10% of entanglements are detected and reported. Rescuers have been injured and lost their…
Medicine & Physiology (Senior Division)
Second Award
Neuroblastoma is a pediatric cancer arising from mutated embryonic nerve cell precursors. It is the most common extracranial pediatric solid tumor, yet current therapies are associated with…
Earth & Environmental Sciences (Track 2) (Junior Division)
Second Award
Kelp forests declined across California in 2014 from sea star wasting disease and a heatwave, though some are now recovering. I was inspired to use accessible technology to explore this hidd…
Physics and Astronomy
Second Award
Quantum computers encode information in qubits, which are susceptible to physical noise. To protect information, quantum systems use error correction codes like the surface code, detecting e…
Biomedical and Health Sciences
Second Award
Evolution has shaped primates to develop two key advanced traits in comparison with lower mammalian species: first higher intelligence with increased brain size and cortical complexity and s…
Environmental Engineering
Second Award
Non-Polar Organic Contaminants (NPOCs) such as Micro/Nano-sized Microplastics (MNMPs), oils and Benzene, Toluene, Ethyl Benzene, Xylene (BTEX) are emerging contaminants that are critical thr…
Physics & Astronomy (Junior Division)
Second Award
This project investigated whether electrical impedance could be used to detect contamination in water. The hypothesis was that increasing levels of contamination would increase the conductiv…
Environmental Engineering (Track 2) (Senior Division)
Second Award
Wildfires have escalated into a global environmental catastrophe, and traditional suppression methods are increasingly insufficient. While prescribed burning is a critical mitigation tool, c…
Environmental Engineering (Senior Division)
Second Award
Abstract: Introduction: Plastics are one of the most widely used materials on the planet. They are mostly made from petroleum-based polymers, which can be molded into a variety of shapes and…
Computational Science (Senior Division)
Second Award
Over 80 million people face loss of upper-limb function. However, modern non-invasive electroencephalogram (EEG) prosthetic hand interfaces are limited to cumbersome, binary movements due to…
Earth and Environmental Sciences
Second Award
Wildfire smoke increasingly impacts agricultural land, specifically in the PNW, yet the effects of seed exposure to smoke remain poorly understood. This study investigated the effects on pla…