38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2026
Biochemistry Fourth Award
Alzheimer’s Disease is a neurodegenerative disorder characterized by the hyperphosphorylation of Tau and collapsin response mediator protein-2 (CRMP2), a newly identified and understudied bi…
ISEF · 2026
Computational Biology and Bioinformatics Fourth Award
This project aims to better predict cancer dynamics to mitigate the effects of drug resistance. This research project uses a dataset from Kaznatcheev et al., who created an evolutionary game…
ISEF · 2026
Biomedical and Health Sciences Fourth Award
Immune thrombocytopenia (ITP), a life-threatening disorder of humans and dogs, leads to spontaneous bleeding from antibody-mediated platelet destruction. Standard immunosuppressive therapies…
ISEF · 2026
Environmental Engineering Fourth Award
Due to high ultrafine particle (UFP) concentrations on freeways and the lack of effective UFP prevention technologies in vehicles, passengers may be exposed to elevated cabin UFP levels duri…
ISEF · 2026
Chemistry Fourth Award
Mercury is a highly toxic heavy metal that poses a serious risk to human health and the environment, affecting an estimated 19 million people worldwide. In aquatic systems, inorganic mercury…
ISEF · 2026
Animal Sciences Fourth Award
Stag beetles are highly popular insects as pets in the world. During the larval stage, a pair of orange spot is observed exclusively on the abdomens of female larvae. These structures common…
ISEF · 2026
Biomedical and Health Sciences Fourth Award
Lactase dietary supplements are widely used to address lactose intolerance, a condition where the small intestine produces insufficient lactase enzyme to break down lactose, the natural suga…
ISEF · 2026
Behavioral and Social Sciences Fourth Award
Mental health disorders affect approximately 23% of American adults, highlighting the need for improved diagnostic tools (NIMH, 2024). Current diagnoses rely on self-reported surveys and cli…
ISEF · 2026
Computational Biology and Bioinformatics Fourth Award
Parkinson's disease (PD) affects over 10 million people globally. It is driven by the intrinsically disordered (IDP) protein a-synuclein (asyn). While asyn's flexibility is functional, it en…
ISEF · 2026
Behavioral and Social Sciences Fourth Award
Many teachers have started using phones as a way to encourage students in the classroom. I wondered how effective this method was, and what some of the undesirable consequences could be. The…
ISEF · 2026
Software Design Fourth Award
As hyper-realistic deepfakes grow into one of the world’s most pressing crises, the rush to secure digital integrity has made watermarking one of the most urgently researched sectors in cybe…
ISEF · 2026
Biomedical and Health Sciences Fourth Award
Human Immunodeficiency Virus (HIV) infection is associated with neurocognitive dysfunction (NeuroHIV), which can occur in 30–50% of people with HIV, despite successful combination antiretrov…
ISEF · 2026
Translational Medical Science Fourth Award
Meniscus injuries are among the most common orthopedic conditions, with approximately 1 million surgeries annually. Injuries in the avascular zone cannot self-regenerate, and modern scaffold…
ISEF · 2026
Plant Sciences Fourth Award
Global warming has led to a significant escalation of the rate of coral bleaching, with 90% of reefs projected to experience bleaching annually by 2050. Coral bleaching often occurs when mar…
ISEF · 2026
Energy: Sustainable Materials and Design Fourth Award
Solar photovoltaics are the fastest-growing renewable energy source, expected to account for over 16% of global electricity generation by 2050. Conventional silicon solar cells are more carb…
ISEF · 2026
Software Design Fourth Award
This project advances audio augmentation in augmented reality (AR) by developing a music-theoretic spatial sonification method. Although AR is increasingly used in education and entertainmen…
ISEF · 2026
Animal Sciences Fourth Award
E-cigarettes are a growing public-health concern, as new studies indicate that heavy metals, including lead, can be found in vape liquid. Despite this desperate need for research, the long-t…
ISEF · 2026
Biomedical Engineering Fourth Award
Fully instrumented gait analysis provides clinicians with critical metrics for surgical planning and rehabilitation. It is the gold standard, combining infrared motion capture and force plat…
ISEF · 2026
Earth and Environmental Sciences Fourth Award
Nine of NOAA’s top 10 costliest natural disasters were major hurricanes, highlighting the logically clear need to protect the 40% of the global population living near coastal areas. Despite…
ISEF · 2026
Energy: Sustainable Materials and Design Fourth Award
Thermoelectric generators (TEGs) remain limited to roughly 6–8% efficiency due to material constraints, but their solid-state design enables exceptional reliability. Thermophotovoltaic (TPV)…
ISEF · 2026
Biomedical and Health Sciences Fourth Award
Purpose: Current anti-cancer adoptive cell immunotherapies have three major hurdles: extraction and preservation of autologous cells; engineering, expansion, and activation of cells ex vivo;…
ISEF · 2026
Physics and Astronomy Fourth Award
The assembly of Brightest Cluster Galaxies (BCGs) is commonly attributed to hierarchical mergers at low redshift, yet the mechanisms governing their early-universe growth remain poorly quant…
ISEF · 2026
Cellular and Molecular Biology Fourth Award
Parkinson's disease progression is worsened by chronic neuroinflammation and excessive microglial activation, making inflammatory pathways promising therapeutic targets. Among these strategi…
ISEF · 2026
Computational Biology and Bioinformatics Fourth Award
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a 90% mortality rate. Standard treatments such as surgery and chemotherapy show high recurrence rates of ~85% due to PD…
ISEF · 2026
Biochemistry Fourth Award
Silk fibroin is a sustainable biopolymer with extraordinary mechanical properties derived from its hierarchical self-assembly into ß-sheet nanostructures. Biological silk spinning leverages…
ISEF · 2026
Software Design Fourth Award
Severe Speech and Motor Impairment (SSMI), including conditions like advanced-stage ALS, progressively traps individuals in their bodies. This loss of muscle control and communication abilit…
ISEF · 2026
Technology Enhances the Arts Fourth Award
Kintsugi is a traditional Japanese restoration technique for repairing broken objects, making them more beautiful and cherished over time. Rather than hiding damage, kintsugi highlights repa…
ISEF · 2026
Microbiology Fourth Award
CRISPR–Cas systems enable bacteria to defend against viral infection through RNA-guided nucleases and accessory proteins, though the functions of many accessory components remain unclear. Th…
ISEF · 2026
Cellular and Molecular Biology Fourth Award
Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral cancers, with 5-year survival rates below 60% due to late-stage diagnosis. Current diagnostic approaches rely on invasive su…
ISEF · 2026
Earth and Environmental Sciences Fourth Award
Known as the “rainforests of the sea” coral reefs support over 1 billion people. Yet the rising ocean temperatures have driven increasingly frequent coral bleaching events, threatening reefs…