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Which Commercial Ibuprofen Tablet Has the Greatest Dose Variation?

CSEF · 2003 Chemistry

Gautam S. Vaidyanathan · Ayer (Bernice) Middle School, San Clemente

Overview

Objectives/Goals My objective was to assay Ibuprofen in commercial Ibuprofen tablets by High Performance Liquid Chromatography in order to determine which brand of commercial Ibuprofen tablet has the greatest dose variation. Methods/Materials Four brands of Ibuprofen caplets (200 mg), namely, Motrin, Advil, Sav-On, and Kirkland were chosen. Ten caplets from each brand were tested for Ibuprofen content using High Performance Liquid Chromatography. The assay procedure as described under the monograph for Ibuprofen Tablets in the United States Pharmacopeia was followed with minor modifications. The percent assay, standard deviation and relative standard deviation were calculated for each brand. The RSD values were compared. Results The percent assay value, for each of the ten caplets tested, for all brands of Ibuprofen, was within the specification required by the USP monograph. The Advil brand of Ibuprofen caplets had the highest relative standard deviation for percent assay values at 1.64. Motrin had the lowest RSD at 1.07. Thus, the brand of Ibuprofen that had the greatest dose variation was Advil. Conclusions/Discussion I thought that large pharmaceutical companies, which manufacture Motrin and Advil, most probably spend more money on optimizing their manufacturing process. Through this optimization they will be able to achieve more accurate amounts of Ibuprofen and hence have a small dose variation. Of the other two generic brands, I hypothesized that the Kirkland brand would have a greater dose variation than the Sav-On brand because Sav-On is a pharmacy while Kirkland/Costco sells many different products. However, my data did not support my hypothesis. Advil brand of Ibuprofen had the greatest dose variation.

Summary statement

To determine which commercial Ibuprofen tablet has the greatest dose variation.

Help received

used laboratory facilities, equipment, and instruments at GRAM Laboratories, Inc. under the supervision of my father, Rajaram Vaidyanathan. My father helped me type the report.

Awards (1)

  • Category Award

Competition history

  • CSEF 2003 Chemistry · Entry J0532

Resources

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