Vadam: Volatile Analyte Diagnostic Aid Machine

Overview

Volatile Organic Compounds (VOCs) are organic chemicals that readily vaporize at room temperature and are emitted from diverse sources, including paints, building materials, and biological processes. While the understanding of VOC production within the human body remains limited, it is well-established that VOCs arising from cellular metabolic activities accumulate in significant concentrations in the bloodstream. As cellular processes are disrupted by bacterial or viral infections or the onset of cancer, these metabolic pathways undergo substantial alterations, leading to distinct changes in the VOC profiles generated by lymphocytes and other cell types. These alterations manifest in the VOC composition present in the blood and exhaled breath. This study sought to develop and test a device that analyzes VOC values to diagnose different lung cancers. To perform this analysis, this study used mice from a NSCLC study separated into three populations: controls, those expressing virally induced tumors, and those expressing tumors treated by an inhibitory drug. The device was able to detect a considerable difference in VOC concentrations between populations, which could potentially be used for lung cancer diagnoses in human models. These results present VOC-based electronic nose technology as a viable alternative to current lung cancer screening methods.

Competition history

• AJAS 2025 Category not listed

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