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The Impact of Pollution on Brain and Vascular Systems on Zebrafish Model, Danio Rerio

AJAS · 2024

Vivianna Weaver · Kentucky Academy of Science

Overview

D. Rerio are commonly utilized to evaluate environmental pollution effects on human health, due to their genetics and structure being similar to those in humans. Significant disruptions can be seen when exposed to a class of chemicals known as dioxins. One type of dioxin, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), activates the aryl-hydrocarbon receptor through a ligand-activated response. This activation triggers disruption in DNA sequencing and gene expression. Our study evaluated the effects of this gene-expression disruption on D. Rerio cerebral vasculature and lymphatics. We concluded that both the vascular and lymphatic endothelium are disrupted in TCDD-exposed embryos and that brain lymphatics are not developed at the same time point as the vasculature in D. Rerio. These findings indicate that TCDD may trigger gene-expression disruption in the human model and potentially have effects on the vasculature of the human brain.

Competition history

  • AJAS 2024 Category not listed

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Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

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