fairfolio
Saved Projects

The Effect of Multiple Sequence Alignment Guide Tree Choice on the Topology of the Alignment-Based Phylogeny

ISEF · 2016

Liu, Joyce

Is this your project?

Overview

Phylogenetic trees of evolutionary relationships are vital to understanding evolution. Phylogenetic tree inference involves the construction of a multiple sequence alignment, which itself depends on the construction of a guide tree. Guide trees have no evolutionary significance but guide the reconstruction of multiple sequence alignment and are expected to influence the construction of phylogenetic trees. In this paper we investigate the relationship between the choice of guide tree and the resulting phylogeny. Using three clustering methods of varying precision (Neighbor-joining, UPGMA, and UPGMB) as well as the true tree, we constructed and analyzed alignments and phylogenies to determine their accuracy and similarity. Results showed a very strong correlation between guide tree accuracy and phylogenetic tree topology, and suggest that the phylogeny may tend to be similar to the guide tree used in its creation process.

Working on something like this? See what's been done and what's still open.

Competition history

Resources

Related projects

Closest projects by meaning, across every fair and year in the corpus.

Browse more like this

Report a problem

Source: Regeneron International Science and Engineering Fair

Save projects to your library

Sign in with Google to keep track of projects you find interesting, organized into folders. An account also raises your daily allowance for “Has this been done?”, and lets you create a key for the MCP server with a much higher limit than anonymous use. Browsing stays public.

Continue with Google