The Effect of Indole-3-Carbinol on Saccharomyces cerevisiae Growth, as a Model for Cancer Cells

Overview

Extensive research has explored cancer cell growth and potential treatments. However, the effects of different concentrations of indole-3-carbinol (I3C) on cancer cell growth remain unclear. This study aimed to determine whether the concentrations of indol e-3-carbinol would impact the growth of Saccharomyces cerevisiae. These findings may have implications for cancer prevention as S. cerevisiae and cancer cells exhibit similar growth properties. It was hypothesized that the higher concentrations of I3C would exhibit more antifungal properties based on previous research showing that I3C tends to shut down harmful pathways, such as the Kennedy pathway. This hypothesis was tested using the following concentrations of indole -3-carbinol: 50%, 80%, and 100%, with 100% being a 2.5 g I3C solution. Zone of inhibition disks, soaked in different I3C concentrations, were placed on S. cerevisiae streaked petri dishes. The amount of antifungal activity (in mm) was recorded. The results from the ANOVA test with an alpha value of .05 showed that there were significant differences between the experimental groups and the control (F(3, 116) = 117.36, p<.0001). A post hoc Tukey test was performed and it was found that there were significant differences between each experimental group. It was concluded that there was sufficient evidence to suggest that higher concentrations of I3C led to more antifungal activity against S. cerevisiae compared to the lower concentrations.

Competition history

• JSHS 2025 Category not listed

Resources

• National JSHS abstract book ↗

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