fairfolio
Saved Projects

The Effect of Exercise on Thermogenesis in Brown Adipose Tissue

CSEF · 2018 Mammalian Biology Third Award

Aditi T. Venkatesh · BASIS Independent Silicon Valley, San Jose, Santa Clara County

Overview

Objectives/Goals This study was performed to understand the relationship between exercise and thermogenesis in Brown Adipose Tissue. Many researchers believe that studying BAT in addition with other energy expenditure processes, such as exercise, could lead to a cure or a better understanding of obesity. Methods/Materials Six mice were used and randomly split into two groups: interscapular and mid back. Temperature of interscapular was measured to find temperature of the Brown Adipose Tissue and temperature of the mid back was measured to find core body temperature. Temperature was measured using the Anipill, a novel telemeter, or temperature reading device. Mice were acclimated on an exercise treadmill for three days, staying at rest for twenty minutes and then exercising for two minutes at 5 m/min on Day 1, 7.5 m/min on Day 2, and 10 m/min on Day 3. On the fourth day the SPRINT protocol was executed. The mice were placed on the unmoving treadmill for twenty minutes and then speed was increased by 1 m/min starting at 10 m/min per minute until the mouse was deemed exhausted. Results During the SPRINT protocol, the temperature of the Brown Adipose Tissue decreased as the temperature of the mid back region increased and stayed above baseline. After the average exhaustion point both regions returned to baseline temperature. Conclusions/Discussion Due to the role of Brown Adipose tissue in thermoregulation, it is likely that the increase in temperature of the surrounding muscle tissue caused the BAT to gradually decrease its thermogenesis to preserve thermal homeostasis in the mouse. It is also most likely that the BAT was selectively downregulated by the sympathetic nervous system during exercise.

Summary statement

During exercise the reduced thermogenesis in Brown Adipose Tissue shows that lipolysis is decreased in BAT during exercise.

Help received

Used lab equipment and IACUC and Animal Care facilities at the University of Iowa under the mentorship of Dr. Benson, Participant of the SSTP Iowa Program.

Awards (1)

Competition history

  • CSEF 2018 Mammalian Biology · Entry S1314

Resources

Related projects

Closest projects by meaning, across every fair and year in the corpus.

Browse more like this

Source: California Science & Engineering Fair public projects

Save projects to your library

Sign in with Google to keep track of projects you find interesting, organized into folders. An account also raises your daily allowance for “Has this been done?”, and lets you create a key for the MCP server with a much higher limit than anonymous use. Browsing stays public.

Continue with Google