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Revisit to the Synthesis of 1-(2-fluorophenyl)-1H-imidazole

CSEF · 2019 Chemistry

Eva Y. Chen · Kastner (George W.) Intermediate School, Fresno, Fresno County

Overview

Objectives My objective is to get the correct building block for future medicinal compounds (which is 1-(2- fluorophenyl)-1H-imidazole) and get a high yield percentage. Methods I tested phenyldihalide variety, base variety, reaction time, and the reaction temperature. These reactions varieties were tried in hope to synthesize 1-(2-fluorophenyl)-1H-imidazole. Results After many trials and errors, I was successfully able to synthesize 1-(2-fluorophenyl)-1H-imidazole with a high yield percentage. Conclusions Using 2-iodo-1-fluorobenzene as the phenyldihalide and potassium carbonate instead of cesium carbonate as base led to the synthesis of my desired product.

Summary statement

After many trials and errors I was successfully able to synthesis 1-(2-fluorophenyl)-1H-imidazole.

Help received

Qiao-hong Chen, California State University Fresno

Competition history

  • CSEF 2019 Chemistry · Entry J0608

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