Re-administration of Different Doses of Tetracycline and Ciprofloxacin in Combination Therapy to Pre - treated Escherichia coli to Determine if Antimicrobial Resistance Transfers to New Colony

Overview

Allison Hennings Oak Park and River Forest High School Antimicrobial resistance is a serious problem in global public health and has not shown signs of slowing or stopping despite scientific advances. With lack of new antibiotics being produced and an absence of research regarding resistance patterns of bacteria over time, resistance continues to grow. This experiment sought to determine if bacteria (already treated with antibiotics in combination therapy) is more or less resistant when the same antibiotic combination is readministered. By comparing the zones of inhibition (ZOIs) from the baseline and recolonized bacteria, an increase in resistance was observed. It was concluded that the ZOIs of the recolonized (RC) bacteria were smaller than the ZOIs from the baseline (B) bacteria. An ANOVA test revealed a calculated p value of p=.013. This suggests that if a bacterial colony has already shown resistance to an antibiotic combination, re-administering the antibiotic combination in hopes of increased susceptibility will prove ineffective. Further research is required to effectively control antibiotic resistance and potentially reduce the severity in global public health today.

Competition history

• JSHS 2020 Category not listed

Resources

• National JSHS abstract book ↗

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