Photodynamic Therapy Based on Eosin Y Transport Using Boron Nitride Nanotubes and Carbon Nanotubes to Induce Apoptosis in Pancreatic Cancer Cells

Overview

Photodynamic therapy is the combination of a light source that stimulates a photo -sensitizing agent in an oxygen-rich environment triggering the production of singlet oxygen, causing apoptosis. Due to the complication in the detection and prevention of pancreatic cancer, it is proposed to determine if PDT based on the transport of eosin -Ythrough BNNTs and CNTs will be an effective method to induce apoptosis in pancreatic cancer cells. If the treatment in KPC cells treated with eosin Y, and both nanotubes produce 1O2 and it maintains its high reactivity, then a higher concentration will induce oxidative damage and apoptosis in KPC cells. There were 4 Control Groups and 2 Experimental Groups. Group I was not altered, while nanotubes with eosin -Ywere added to Groups II and III and cell irradiation was avoided. The IV was irradiated without the presence of nanotubes or eosin -Y. The Experimental Groups were treated with nanotubes and eosin-Ytogether with cell irradiation. The effectiveness of the treatment was determined by performing a Ttest. The eosin -Ysamples together with BNNTs and CNTs at 25% turned out to be statistically different at a significance level of 80%. At a concentration of 100%, the BNNT solution was found to be significantly different at a l evel of 80% and the CNTs solution at a level of 90%. As the concentration of the solutions increased, to 25 and 100%, the values became statistically different. PDT performed on pancreatic cancer cells with both solutions was found to be effective.