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Over 60 Single Nucleotide Polymorphisms Across 8 Chromosomes are Shared by 7 Distinct Cancer Types

JSHS · 2023

Bowen Jiang, Robert Aguilar · Western Reserve Academy, Cleveland, OH

Overview

Successful cancer treatment relies on understanding its etiology and the early detection of symptomatic patients. The identification of single nucleotide polymorphisms (SNPs) shared between distinct cancers can assist in furthering our understanding and may also serve as possible biomarkers. T o investigate this objective, whole genome sequencing data were obtained from the Sequence Read Archive, and then analysis pipelines were constructed to map the sequences against different chromosomes followed by indexing and variant calling. T o date, 8 chromosomes have been analyzed and over 60 SNPs found to be shared by 7 distinct cancers that range from breast to prostate cancer. Our analyses have identified cross-cancer SNPs that lay the foundation for future etiological studies and suggest that different cancers share common SNPs that may serve as suitable biomarkers.

Competition history

  • JSHS 2023 Category not listed

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Source: Junior Science and Humanities Symposium

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