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Novel Applications of Native Sonoran Desert Plants (NSDP), Year 3 Study

ISEF · 2023 Microbiology

Romero, Andrea · Harvest Preparatory Academy

Overview

Antibiotic resistance is one of the most urgent public health issues. To address this problem, this study investigated the possible applications of Native Sonoran Desert Plants (NSDP) against antibiotic resistance. A tablet binder was created using extract of honey mesquite (Prosopis glandulosa) leaves obtained using a rotary evaporator and tablets of Ampicillin and different concentrations of Prosopis glandulosa extract were produced using a manual tablet molder. Tablets with carboxymethylcellulose were used as a control. Antimicrobial assays (Kirby-Bauer and Area Coverage Analysis) were performed to test the efficiency of the tablets. Toxicity assays were also conducted. Data were analyzed using R- studio, Microsoft Excel, and Image J. The results showed that Prosopis glandulosa increased the antibiotic effects of Ampicillin (t-test, p<0.05). Hence, Prosopis glandulosa can be used as a potential tablet binder. The bioplastic infused with NSDP extract demonstrated great antimicrobial effects against E. coli (Larrea- 94% inhibition, Prosopis- 69% inhibition). This research presents potential applications of NSDP on mitigating antibiotic resistance.

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Source: Regeneron International Science and Engineering Fair

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