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Illinois-Chicago A Comparison of Zingiber officinale Mediated Synthesis of Copper Nanoparticles and Chemically Synthesized Copper Nanoparticles Through Their Effects on Drosophila melanogaster Locomotion for In Vivo Medical Applications

JSHS · 2024

Jenna Ahn, Kathleen Ngo · Oak Park and River Forest High School, Oak Park IL Supervisor: Mrs. Allison Hennings R.N., B.S.N., M.A.T., Oak Park and River Forest High School

Overview

Institute of Technology, Kanpur This experiment studied the effects of ginger -mediated and chemically synthesized copper nanoparticles (CuNP) on the model organism Drosophila melanogaster (D. melanogaster). Nanotechnology is a rapidly evolving field in which nanoparticles (NP) are pioneering developments, particularly in medicine. Metal NPs have been shown to display antibacterial, antiviral, and anticancer properties. However, the in vivo cytotoxic effects of these particles are not fully known. Much research has suggested the incorporation of biological materials to increase the biocompatibility of these particles. To test this hypothesis, this experiment investigated chemically synthesized CuNP compared to ginger -mediated CuNP. D. melanogaster was analyzed to further understand the effects of CuNP on living organisms. After NP characterization using TEM, DLS, and UV -visible spectroscopy, 3 separate dosages of the NP were incorporated into fly media. A climbing assay was used to observe the effects on locomotion and geotaxis of the D. melanogaster adults and their larvae. A 2-way analysis of variance (ANOVA) showed no statistically significant differences in climbing (p > 0.1 for both copper and ginger CuNP) however did find substantial evidence to attribute variation in larval crawling to CuNP treatment when compared with a control (p<0.001). These findings support the concerns of present research regarding the toxicity of chemically synthesized NPs in particular. With further research, biologically synthesized NP could be developed and implemented in academic, commercial, and military settings as biologically compatible antimicrobial, antiviral, and anticancer agents.

Competition history

  • JSHS 2024 Category not listed

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