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Identifying Possible Biological Processes Affected by Non-Target Proteins of SARS-CoV-2

AJAS · 2024

Priya Emani · Washington Academy of Sciences

Overview

SARS-CoV-2 has spurred remarkable interest in vaccine development and our understanding of the virus’ enduring effects. My research is aimed at identifying the repertoire of potential receptor interactions of SARS-CoV-2 and utilizing comparable proteins to elucidate their impact on organs, potentially contributing to the development of long COVID. The Angiotensin Converting Enzyme 2 (ACE2) receptor is the host-cell ligand required for cell entry through its interaction with the virus spike protein. Using tools from NCBI, I identified collectrin as the closest homologous receptor protein candidate (40.87% amino acid similarity) and found that this protein is mostly expressed in kidney tissue. Interestingly, kidney damage is a known complication from SARS-CoV-2 infection, although concurrent expression of ACE2 in the kidney confounds our ability to assess a causal relationship between collectrin and SARS-CoV-2 induced kidney damage. Understanding the presence and functions of collectrin could contribute to the treatment of long-COVID syndrome, which represents the lingering effects of the SARS-CoV-2 infection. This research provides valuable insights and helps understand the after-effects of the SARS-CoV-2 infection.

Competition history

  • AJAS 2024 Category not listed

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Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

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