Harnessing Inhibition of Efflux to Reverse Antifungal Resistance

Overview

Fungal pathogens pose an enormous threat to global health, and a growing number of pathogens are developing resistance to our limited arsenal of antifungals. Overexpression of efflux pumps to expel antifungals is the main mechanism of antifungal resistance. My project successfully repurposed underexplored compounds to inhibit efflux activity in the clinically relevant antifungal-resistant pathogen Candida albicans, reversing antifungal resistance. I analyzed the minimum inhibitory concentrations of the compounds and activity against filamentous fungi, and quantified efflux inhibition and compound cytotoxicity against human liver cells. My novel project provides an incredibly promising strategy to reverse antifungal resistance.

Awards (4)

• Platinum Award
• Challenge Award
• Gold Medal
• Selected for CWSF 2026

Competition history

• CWSF 2026 Curiosity & Ingenuity

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