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Effect of DCG-IV on Antidromic Population Spikes in the Hippocampal CA3 Region

CSEF · 2007 Mammalian Biology

Sargis Pogosjans · Bravo (Francisco) Medical Magnet High School, Los Angeles, Los Angeles County

Overview

Objectives/Goals Past Research has shown that DCG-IV, a group II metabotropic glutamate receptor (mGluR) agonist, presynaptically inhibits the activity of the CA3 region of the hippocampus. It logically follows that the CA3 should exhibit well correlated population spikes amplitudes whether the drug is present or absent. By stimulating the Schaffer Collaterals in rat hippocampus slices and recording the antidromic response for each scenario (drug present in extracellular environment and drug absent) can be compared to determine the effect of DCG-IV on the antidromic excitation of CA3.

Summary statement

To Further the Understanding of the Hippocampus and it's Antidromic Behaviors.

Help received

Used lab equipment at USC under the supervision of Dr. Ted Berger.

Competition history

  • CSEF 2007 Mammalian Biology · Entry S1115

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