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Developing a Novel Flexible MoS2 Biosensor to Detect Lower-Concentrated Biomolecules at the Femtomolar Level

CSEF · 2017 Chemistry Fourth Award

Erika Yang · Granada High School, Livermore, Alameda County

Overview

Objectives/Goals The object of this study is to develop a novel flexible MoS2 biosensor to detect very lower-concentrated biomolecules. Methods/Materials I successfully fabricate a MoS2 biosensor on polyimide film, a flexible substrate which has great potential applications. The MoS2 biosensors can be used for rapid biomolecule quantification at fM-levels by analyzing the initial slopes of time-dependent response curves. The flexible MoS2 biosensors exhibited a detection limit for biomolecules as low as 50 fM that is about 10,000 times lower concentration than that can be detected by the conventional biosensor like ELISA. Results The fabricated MoS2 biosensors can be used for rapid biomolecule quantification at fM-levels by analyzing the initial slopes of time-dependent response curves. The multiple sensors can be utilized to enable quantification of low-abundance biomarker molecules as well as the affinities and kinetics of antibody-mediated binding events. The flexible MoS2 biosensors exhibited a detection limit as low as 50 fM that is about 10,000 times lower concentration than that can be detected by the conventional ELISA method. Conclusions/Discussion The MoS2 biosensors can be used for rapid biomolecule quantification at fM-levels by analyzing the initial slopes of time-dependent response curves. The multiple sensors can be utilized to enable quantification of low-abundance biomarker molecules as well as the affinities and kinetics of antibody-mediated binding events. The flexible MoS2 biosensors exhibited a detection limit as low as 50 fM that is about 10,000 times lower concentration than that can be detected by the conventional biosensor like ELISA.

Summary statement

I have successfully fabricated a flexible MoS2 biosensor that can detect biomolecules with a concentration as low as 50 fM that is about 10,000 times lower concentration than the conventional ELISA method.

Help received

I have been working on this project for two years at a research laboratory. They trained me on equipment and I had some discussion with them.

Awards (1)

Competition history

  • CSEF 2017 Chemistry · Entry S0632

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