Continuous Oral-fluid Monitoring of Glucose (O.M.G.) Device with Near Field Communication Capability

Overview

Around 34 million Americans have Type 2 Diabetes (T2D), while 88 million American adults have prediabetes. Different from the traditional invasive needle method, my proposed salivatory glucose-monitoring device, named OMG, can facilitate self-monitoring through a noninvasive method by using cost-effective material and Near Field Communication (NFC) chips. The electrodes that I designed were coated with Glucose Oxidase (GOx), where a biological redox reaction occurs after being in contact with salivary glucose. When the interdigitated electrode (IDE) connects to an NFC tag, the redox reaction strongly changes the impedance of the tag, modulating the electromagnetic reflection from the tag, and reflecting it as the “change of frequency” (which is proportional to the glucose concentration). Afterward, I used both commercial chemical methods and ex-vivo to assess viability and usability, same to in vivo styles. Data were assessed by creating several separate comparisons between OMG and Glucose Colorimetric Assay. SEM images captured GOx’s morphology, Vector Analyzers were used to collect data, and Glucose Assay Kit (Colorimetric) was used for comparison between commercial and OMG. Saliva was collected through regulated protocols and GraphPrism. The results suggest that the trendline is reliable (R2 = 0.9292) for OMG readings and (R2 = 0.8692) for our Performance Tests, which is also comparable to the commercial method. Conclusively, the non-invasiveness and portability demonstrate the necessity of developing such applications.

Competition history

• JSHS 2022 Category not listed

Resources

• National JSHS abstract book ↗

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