Breast Cancer in Young Women: Microbiota, Estrogen, and Bacteria Impact on Biomarker Discovery

Overview

Breast cancer rates have surged among adolescent and young women in the U.S., remaining a main cause of cancer deaths in this demographic. This issue calls for quicker and more efficient diagnostic methods. Breast cancer is related to estrogen, and changes in the breast microbiome are confirmed in breast cancer patients. Estrogen receptors can be found in the breast tissue, and may interact with the breast microbiome. This study investigates the breast microbiome and estrogen in breast cancer for biomarker discovery. In this experiment, E. coli and B. cereus, bacteria found in breast cancer patients, and L. plantarum, which is related to immunity, were used. Each bacterial species was used for growth viewing. When treated with estradiol, only L. plantarum showcased growth, and the other two did not show growth. L. plantarum’s products were sampled under various medium conditions, concentrations and exposure times of estradiol. L. plantarum’s product was tested in various mediums, with and without estradiol. Exposure time was tested, and there was significant growth after 10 hours. Estradiol increases L. plantarum; thus, when L. plantarum’s product increases more, the antibiotic product also increases. When the antibiotic product of L. plantarum is added into the different bacteria, it decreases other bacteria’s product growth. But when L. plantarum’s product decreases, specific bacteria will grow as L. plantarum control loosens. With the testing of its functional ability, L. plantarum can be used as a diagnostic tool with its relationship with estrogen serving as a crucial marker for breast cancer diagnosis.

Competition history

• AJAS 2025 Category not listed

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