Blood Biomarkers for Recognizing Mild and Moderate TBI

Overview

Today, there is no accurate way to diagnose Traumatic Brain Injury (TBI), especially when referring to mild or moderate injuries, and no way for medical professionals to guarantee presence and/or severity of some TBI. There is a gap of knowledge surrounding biomarkers of TBI, but they could be a promising solution to diagnosis issues associated with TBI. Some fluid biomarkers, such as those found in blood and saliva, are a noninvasive way for patients to get tests done and receive information on their injuries. This study aimed to identify potential fluid biomarkers that could be used to diagnose TBI. It involved three datasets sourced from the Gene Expression Omnibus (GEO), all three of which are blood samples. The analysis was done on mild and moderate lev el TBI that was inflicted in a variety of ways including via direct impact, sports injuries, and another undisclosed cause. Analysis was done using bioinformatics. With bioinformatics I was able to use online software to sift through and extract patterns f rom complex biological data. Specifically, samples were run through GEO2R, with secondary analysis using Venn diagrams and STRING cluster analysis. The cluster analysis provided me with biological processes of the most significant clusters. The analysis showed evidence that blood biomarkers could be a promising solution to the difficulties surrounding mild and moderate traumatic brain injury.

Competition history

• JSHS 2024 Category not listed

Resources

• National JSHS abstract book ↗

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