Behavioral and Social Sciences
Major depressive disorder (MDD) affects over 332 million people worldwide and is a leading cause of disability. Duloxetine is a widely prescribed antidepressant; however, discontinuation is…
Chemistry
Conventional methanol production relies on a two-step process, where carbon dioxide is first converted into synthesis gas (syngas) and then methanol. This syngas step requires increased ener…
Computational Biology and Bioinformatics
Agricultural pesticide use remains substantial, increasing chemical exposure, environmental burden, and production costs. U.S. farms spent $21.7 billion on agricultural chemicals in 2024. Be…
Chemistry
Chiral cyclopropanes are privileged structural motifs in pharmaceutical chemistry, essential for enhancing the potency and metabolic stability of therapeutics, including next generation anti…
Translational Medical Science
Esophageal obstruction caused by cancer and benign strictures can severely impair swallowing, leading to poor nutrition and reduced quality of life. Although conventional stents are commonly…
Environmental Engineering
While global oil production exceeds 100 million barrels per day, over 40 million liters of crude oil have contaminated marine ecosystems since 2020, resulting in catastrophic ecological and…
Biochemistry
Cancer remains a leading cause of death worldwide, accounting for approximately 10 million deaths annually, and is strongly associated with genome instability and replication stress. Aphidic…
Microbiology
Biofilm-mediated resistance is a major barrier to treating Pseudomonas aeruginosa infections. Biofilms are estimated to contribute to over 65% of microbial infections, allowing bacteria to p…
Chemistry
The limitations of traditional CO2 capture technologies and the rapid rise in CO2 emissions necessitate efficient methods and materials for CO2 capture and conversion under mild conditions.…
Environmental Engineering
Interfacial solar steam generation systems offer a promising solution to freshwater scarcity and energy-intensive desalination. However, most current research uses hydrophilic membranes that…
Biomedical Engineering
Chronic kidney disease (CKD) is a major global health problem affecting over 850 million people, with direct costs exceeding 372 billion USD annually. Uric acid is an important renal biomark…
Energy: Sustainable Materials and Design
Battery life remains a critical limitation in wearable electronics, as frequent charging shortens device lifespan and contributes to electronic waste. Hybrid TENG–PENG designs are promising;…
Computational Biology and Bioinformatics
Alzheimer's disease (AD), a multifactorial neurodegenerative disorder, is associated with amyloid-beta aggregation, tau hyperphosphorylation, neuroinflammation, apoptosis, and endoplasmic re…
Chemistry
Global carbon dioxide (CO2) emissions exceed 37 billion tons annually, intensifying climate change and motivating technologies that convert CO2 into valuable chemicals. Electrochemical CO2 r…
Biomedical Engineering
Electrocardiography (ECG) is the primary diagnostic method for cardiovascular disease, the leading cause of mortality. Conventional wet ECG electrodes (Ag/AgCl) are metal-based and rely on c…
Materials Science
Titanium alloys are widely used in biomedical implants due to their high strength-to-weight ratio, corrosion resistance, and biocompatibility. However, the standard Ti–6Al–4V alloy contains…
Plant Sciences
Global food demand requires sustainable strategies to enhance cereal productivity beyond conventional agricultural inputs. The apocarotenoids beta-Cyclocitral (beta-CC) and 3-OH-beta-Cycloci…
Materials Science
The production of Portland cement accounts for approximately 7–8% of global CO2 emissions due to energy-intensive calcination processes, underscoring the urgent need for sustainable alternat…
Materials Science
Button Battery Ingestion (BBI) constitutes a global emergency, reporting over 300,000 cases annually, primarily affecting children under six due to natural exploration, resulting in hundreds…
Energy: Sustainable Materials and Design
Global fossil fuel combustion emits 40 billion metric tons of CO2 annually, driving climate change and energy insecurity. Renewable-powered water electrolysis offers a sustainable pathway to…
Embedded Systems
Currently, conventional computing systems that follow Von Neumann architecture face limitations, as the memory and processing units are separated. The memristor has emerged as a promising ca…
Plant Sciences
Abiotic stresses reduce global crop yields by up to 70%, threatening global food security. While stress-responsive pathways are well studied, the role of deubiquitination in plant developmen…
Behavioral and Social Sciences
Hypertension affects over 1 billion individuals globally, and long-term treatment is frequently compromised by poor medication adherence, fixed-dose inflexibility, and polypharmacy complexit…
Computational Biology and Bioinformatics
Sickle cell disease (SCD) remains a major global health challenge, with no widely accessible targeted cure and most existing therapies focused on symptom management or partial disease modifi…
Earth and Environmental Sciences
Oil spills are among the most serious environmental threats. They remain difficult to control, and current remediation methods either disperse oil into water or use chemically aggressive tre…
Technology Enhances the Arts
Current speech-to-sign language translation systems cannot express the emotions behind the words, making it difficult for deaf and hard-of-hearing individuals to fully grasp the speaker's tr…
Energy: Sustainable Materials and Design
Hydrogen, the first element in the periodic table, is now becoming the first choice for clean and efficient energy production, serving as a promising energy carrier. However, 95% of hydrogen…
Materials Science
The transition to a clean energy is limited by the high cost of green hydrogen production, relying ?on expensive noble metals electrocatalysts. This creates supply chain risks and restricts…
Biomedical and Health Sciences
Fibromyalgia is a chronic disorder characterized by widespread pain, fatigue, and cognitive impairments. Current treatments primarily target symptoms rather than underlying pathology. Growin…
Environmental Engineering
Global lithium demand is projected to increase by nearly 4000% by 2040 due to expansion of electric vehicles and energy storage systems; however, current extraction methods are water-intensi…