ISEF 2026 Computational Biology and Bioinformatics winners

25 of the 92 Computational Biology and Bioinformatics projects at ISEF 2026 won a Grand Award. Here's every one, with its abstract.

First Award 2

ISEF · 2026

A Markov Chain Model for Predicting ETI Resistance Breakdown in Tomato–Pseudomonas syringae

Computational Biology and Bioinformatics First Award

Agricultural pesticide use remains substantial, increasing chemical exposure, environmental burden, and production costs. U.S. farms spent $21.7 billion on agricultural chemicals in 2024. Be…

ISEF · 2026

A Multi-Modal Deep Learning Pipeline Integrating Physics-Informed Neural Networks and 3D Image Processing for Accurate Rupture Prediction and Data-Driven Surgical Planning of Cerebral Aneurysms: Year 3

Computational Biology and Bioinformatics First Award

Background: Rupture of cerebral aneurysm, an abnormal bulging of the arterial wall, can lead to brain hemorrhage and stroke. Endovascular surgical treatment is highly invasive and poses sign…

Second Award 5

ISEF · 2026

A Multi-Omic “Digital Embryo” Framework to Model Early Human Preimplantation Development In Silico

Computational Biology and Bioinformatics Second Award

Nearly 50% of human IVF embryos arrest before reaching the blastocyst stage, yet the molecular mechanisms causing this failure remain poorly understood. Current literature examines omics in…

ISEF · 2026

A Unified Protein Embedding Model With Local and Global Structural Sensitivity

Computational Biology and Bioinformatics Second Award

Structural comparison between proteins is key to many research tasks, including evolutionary analysis, peptidomimetics, and functional annotation. Traditional structure alignment tools such…

ISEF · 2026

Beating the Odds in Drug Discovery With 3DICE: Interpretable 3D Cross-Modal Learning for Drug–Target Interaction Prediction at Scale

Computational Biology and Bioinformatics Second Award

Drug–target interaction (DTI) prediction is a crucial step in modern drug discovery. Accurate and efficient predictions can substantially reduce costs and development time. While deep learni…

ISEF · 2026

Biophysical and Genomic Drivers of Targeted Therapy Resistance: Analysis of Growth Dynamics in Non-Small Cell Lung Cancer

Computational Biology and Bioinformatics Second Award

Resistance to targeted therapies in non-small cell lung cancer (NSCLC) limits treatment efficacy. Mathematical models have shown promise in predicting resistance development by capturing bio…

ISEF · 2026

Designing and Delivering Molecular Glue Degraders for the Total Elimination of Previously Undruggable Pathogenic Proteins

Computational Biology and Bioinformatics Second Award

The human proteome comprises ~20,000 unique proteins, yet only 3,000 are theoretically druggable given current therapeutic methods. Molecular glues (MGs) are therapeutics that eliminate path…

Third Award 8

ISEF · 2026

A Multimodal Approach to Real-Time Seizure Prediction Using Discreet Wearables

Computational Biology and Bioinformatics Third Award

Epilepsy is a neurological disorder characterized by recurrent seizures, and affects nearly 50 million people, causing ~140,000 deaths worldwide annually. Many of these deaths could be preve…

ISEF · 2026

Computational Pipeline for High-Throughput 3D Quantification of Cell States in Polymorphonuclear Neutrophils

Computational Biology and Bioinformatics Third Award

Reliable characterization of cell states, which encompass a cell's function, environment, and structure, is fundamental to comprehending healthy cell function and transition into diseased st…

ISEF · 2026

GeneSTRATA: An Outcome-Aware Multimodal Hierarchical Bayesian Framework for Biologically Structured Autism Subtype Discovery and Prognostic Stratification

Computational Biology and Bioinformatics Third Award

Autism Spectrum Disorder (ASD) exhibits substantial heterogeneity in long-term developmental outcomes. Children with similar early symptoms often follow divergent cognitive and adaptive-func…

ISEF · 2026

GlueForge: A Generalizable Pipeline for Molecular Glue Discovery via Multi-Stage Screening and Geometry-Aware Ternary Learning, Demonstrated at the FBW7–MYC Interface

Computational Biology and Bioinformatics Third Award

Despite decades of therapeutic development, most disease-associated proteins remain therapeutically inaccessible. These so-called “undruggable” targets typically lack suitable binding pocket…

ISEF · 2026

H.E.P.A.R (Hepatic Ensemble Predictive Analysis Resource): A Convergent Machine Learning Architecture for Drug-Induced Liver Injury Prediction

Computational Biology and Bioinformatics Third Award

Drug-induced liver injury (DILI) accounts for 13% of acute toxicity cases in the U.S. and remains a primary barrier to pharmaceutical development. While most machine learning models predict…

ISEF · 2026

Simulating Quantum-Coherence Dynamics in ALS Neuronal Ion Channels via Lindblad Master Equation: A Computational Biophysics Approach

Computational Biology and Bioinformatics Third Award

The incurable nature of Amyotrophic Lateral Sclerosis (ALS) is compounded by a diagnostic lag, where symptoms emerge only after irreversible motor neuron attrition. Rather than viewing ALS s…

ISEF · 2026

Spatial Transcriptomics-Conditioned Latent Diffusion Models for Synthetic Histopathology Tissue Patch Generation

Computational Biology and Bioinformatics Third Award

Whole-slide histopathology images(WSIs) form the backbone of AI development in cancer research. However, their high curation cost, gigapixel complexity, and limited availability across insti…

ISEF · 2026

THALis: A Topology-Preserving Brain-Computer Interface for Dexterous Non-Invasive EEG-Driven Hand Control

Computational Biology and Bioinformatics Third Award

Over 80 million people face loss of upper-limb function. Yet noninvasive electroencephalogram (EEG) prosthetic hand interfaces are limited to cumbersome, binary control due to severe signal…