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A Novel CNN-Based Method Using Genetic Data for Early Prediction of Alzheimer's Disease

Computational Biology and Bioinformatics

Alzheimer’s disease affects over 55 million people worldwide, making early prediction crucial for timely interventions to slow disease progression and improve quality of life. Single Nucleot…

A Novel Computational Generative Model That Identifies Ligands: A Potential Way to Reduce Cost & Time in Identifying Promising Drug Candidates

Computational Biology and Bioinformatics

Drug discovery is intricate and costly. Current methods in de novo drug design rely on undiversified and scarce datasets due to the impossibility of recording all intermolecular interactions…

A Novel Convolutional Neural Network to Detect and Classify Brain Tumors

Translational Medical Science

Brain tumors represent a critical health challenge, affecting thousands of individuals annually and often leading to significant harm and mortality. Such challenges highlight the need for in…

A Novel Design to Tailor Microstructures of Nanowire Foams as Efficient, Reusable Filters

Materials Science

Frequent forest fires, persistent air pollution, and the COVID-19 pandemic have sparked a surge in the widespread use of disposable face masks. At the height of the pandemic, 1.6 million ton…

A Novel Device for in situ Removal of Microplastics From Riverbed Sediment via Laser-Induced Particle Fluorescence

Environmental Engineering Third Award

Since the invention of modern plastics during the 20th century, microplastics (MPs) have become one of the most pervasive anthropogenic pollutants on Earth—being found everywhere from the Ma…

A Novel Eco-Friendly Approach for Eliminating E. coli Using Natural Materials Without Chemicals to Promote Environmental and Human Health

Biomedical and Health Sciences

Escherichia coli (E. coli) is one of the primary bacterial causes of urinary tract infections (UTIs), accounting for 75–95% of cases. Conventional antibiotics are commonly used for treatment…

A Novel Energy-Saving Peltier Cooler Using Thermoelectric Conversion From Low-Temperature Waste Heat

Energy: Sustainable Materials and Design

Low-temperature waste heat is an underutilized resource in industries, and energy-saving technologies can progress through the exploitation of this waste heat. In this study, we developed a…

A Novel Faraday Cup: Designing, Printing, and Testing a Conductive Plastic Faraday Cup

Materials Science

A Faraday cup is a conductive cup that serves as a plasma detector, catching the charged particles in a vacuum and measuring the particle flow rate. Due to its advantages in being simple, ac…

A Novel Flow-Based Amine-Conjugated Gold Nanoparticles as a Sensor for Salivary Cortisol Detection

Biochemistry

A rapid and simple method for detecting cortisol, a stress hormone, in saliva was developed for the early diagnosis of stress-related diseases. The detection was based on the reaction betwee…

A Novel Framework for PDF-Based Stegomalware Detection Using Kolmogorov Complexity

Systems Software Third Award

PDF-based stegomalware is a growing cybersecurity threat that disguises malicious payloads within the tree structure of PDF documents, exploiting features like embedded JavaScript, metadata,…

A Novel GenAI Approach To Generate De Novo Terpene Synthase Enzymes By Fine-Tuning ProtGPT2

In the vast protein space of 1 billion functional proteins, about 750 million functional proteins remain unexplored today. De novo proteins in this vast space have numerous life -changing ap…

A Novel Genomic Framework for Personalized Medicine: Optimizing LMTX for Tau Proteins in Alzheimer's

Computational Biology and Bioinformatics

Tau protein aggregation is a hallmark of Alzheimer's disease (AD), disrupting neuronal function and impairing synaptic signaling. The clinical efficacy of tau aggregation inhibitors like TRx…

A Novel Hadronization Model for Charm-Quark

Physics and Astronomy (inferred)

The study of hadronization, the process of quarks combined into hadrons, is pivotal for understanding the universe's formation, yet current theories inadequately explain this process. This s…

A Novel Hybrid-Powered Low-Cost System for Volcanic Hazard Detection

Energy: Sustainable Materials and Design

Volcanic eruptions pose severe risks to human lives, infrastructure, and the environment, affecting 500 million people worldwide. Early warning can reduce fatalities by 60%, yet 80% of 1,500…

A Novel Idea in the Treatment of Edema in Diabetics

Biomedical Engineering

The Flexshoe addresses foot and ankle swelling and circulation issues, especially common in the elderly, targeting conditions like pedal edema, chronic venous insufficiency, and diabetic ede…

A Novel Implementation of Machine Learning in Smart Waste Management Systems

Robotics and Intelligent Machines

Waste pollution, driven by improper recycling practices, remains a pressing environmental issue that humans continually struggle to manage effectively. Building on last year's project, which…

A Novel Low-Cost Zero Mean-Flow Chamber Design and Physics-Informed Neural Network for Astrophysical and Environmental Turbulence Applications

Physics and Astronomy First Award

Turbulence is a natural phenomenon that serves as an underlying principle for many other fields, ranging from astrophysical studies of star formation to climate change modeling. Due to its c…

A Novel Machine Learning Method and Drug for the Diagnosis and Treatment of Depression

Translational Medical Science

Major Depressive Disorder negatively affects millions worldwide by decreasing productivity, degrading physical well-being, and increasing the risk of suicide by 60%. Moreover, miscalculating…

A Novel Magnetic Field-Based UAV Detection System Through Electromagnetic Signal Analysis of Drone Motors: A Technical Countermeasure for the Russia-Ukraine Conflict

Embedded Systems Fourth Award

The Russia-Ukraine conflict has revealed that fiber-optic controlled UAVs can bypass conventional detection systems. Radar fails against low-altitude targets with small radar cross-sections;…

A Novel Mantis-Shrimp-Based Smart Glove for Stroke Rehabilitation

This research discusses the design and development of a mantis -shrimp-inspired smart glove targeted at aiding stroke therapy. The glove combines soft and rigid materials in a hybrid exoskel…

A Novel Method for Cancer Whole Slide Image Processing Utilizing a Multi-Scale Convolutional Residual Neural Network for Regression

Translational Medical Science

Cancer remains a leading cause of death worldwide, with approximately 10 million fatalities annually. Whole Slide Imaging (WSI) and Deep Learning can enhance histopathological analysis, enab…

A Novel Method of Predicting Ocean pCO2 Using a Polynomial Model

Earth and Environmental Sciences Fourth Award

Understanding pCO2 is essential for assessing the ocean's role in the global carbon cycle. However, in many current methods for predicting pCO2, satellite-derived measurements for regional w…

A Novel Method of Water Purification: Optimizing Foam Fractionation for Effective Broad- Spectrum Removal of DBP and DBP Precursors in Chlorinated Drinking Water

University In the 20th century, water treatment plants began using disinfectants like chlorine to eliminate waterborne diseases such as cholera and typhoid. However, this process results in…

A Novel Method of Water Purification: Optimizing Foam Fractionation for Effective Broad-Spectrum Removal of DBP Precursors in Chlorinated Drinking Water

Earth and Environmental Sciences First Award

Water treatment plants use disinfectants like chlorine to eliminate waterborne diseases such as cholera and typhoid. However, disinfection results in the formation of disinfection byproducts…

A Novel Method to Analyze Thermonuclear Explosions in Four Binary Star Systems Using NASA’s High Time Resolution TESS Data

Novae eruptions occur in interacting binary star systems when a white dwarf is accreting mass from its companion. When the shell of material reaches the flash point, a runaway thermonuclear…

A Novel Method to Optimize CAR T-Cell Therapy by Targeting CD25+ T-Cell Malignancies Through Bispecific Aptamer-Mediated ScFv Engagement

Computational Biology and Bioinformatics

T-cell malignancies contribute significantly to the high mortality rates of lung and colon cancers, two of the deadliest globally. Current CAR T-cell therapies, while promising, suffer from…

A Novel Morphing Nose Cone Mechanism for Aerodynamic Optimization of a Supersonic Airplane

Engineering Technology: Statics & Dynamics Fourth Award

The aerodynamic efficiency of an aircraft's nose cone is crucial to overall flight performance. Traditional nose cone designs are optimized for specific speed regimes, which limits their ove…

A Novel Multi-Modal Deep Learning Approach With Attention Mechanisms for Early Detection of Alzheimer's Disease

Translational Medical Science Second Award

Alzheimer's disease (AD) remains difficult to diagnose in its early stages. Current diagnostic approaches often miss subtle early symptoms, delaying intervention. In this research, a novel m…

A Novel Spintronics-based Circulating Tumor Cell Biosensor for Early Metastasis Detection

Biomedical Engineering

Cancer spreads throughout the body in a process named metastasis. Circulating tumor cells (CTCs) play a critical role in promoting metastatic cancers, which cause approximately 90% of cancer…

A Novel Study in the Utilization of Artificial Intelligence, Machine Learning, and Convolutional Neural Networks in the Identification of Differing Recyclable Materials

Robotics and Intelligent Machines

Due to growing industries and poor methods of recycling, landfills are filled with millions of tons of wasted recyclable materials. Making recycling more accessible to communities around the…