Search past science fair projects

A Novel GenAI Approach To Generate De Novo Terpene Synthase Enzymes By Fine-Tuning ProtGPT2

In the vast protein space of 1 billion functional proteins, about 750 million functional proteins remain unexplored today. De novo proteins in this vast space have numerous life -changing ap…

A Novel Genomic Framework for Personalized Medicine: Optimizing LMTX for Tau Proteins in Alzheimer's

Computational Biology and Bioinformatics

Tau protein aggregation is a hallmark of Alzheimer's disease (AD), disrupting neuronal function and impairing synaptic signaling. The clinical efficacy of tau aggregation inhibitors like TRx…

A Novel Hybrid-Powered Low-Cost System for Volcanic Hazard Detection

Energy: Sustainable Materials and Design

Volcanic eruptions pose severe risks to human lives, infrastructure, and the environment, affecting 500 million people worldwide. Early warning can reduce fatalities by 60%, yet 80% of 1,500…

A Novel Idea in the Treatment of Edema in Diabetics

Biomedical Engineering

The Flexshoe addresses foot and ankle swelling and circulation issues, especially common in the elderly, targeting conditions like pedal edema, chronic venous insufficiency, and diabetic ede…

A Novel Implementation of Machine Learning in Smart Waste Management Systems

Robotics and Intelligent Machines

Waste pollution, driven by improper recycling practices, remains a pressing environmental issue that humans continually struggle to manage effectively. Building on last year's project, which…

A Novel Low-Cost Zero Mean-Flow Chamber Design and Physics-Informed Neural Network for Astrophysical and Environmental Turbulence Applications

Physics and Astronomy

Turbulence is a natural phenomenon that serves as an underlying principle for many other fields, ranging from astrophysical studies of star formation to climate change modeling. Due to its c…

A Novel Machine Learning Method and Drug for the Diagnosis and Treatment of Depression

Translational Medical Science

Major Depressive Disorder negatively affects millions worldwide by decreasing productivity, degrading physical well-being, and increasing the risk of suicide by 60%. Moreover, miscalculating…

A Novel Magnetic Field-Based UAV Detection System Through Electromagnetic Signal Analysis of Drone Motors: A Technical Countermeasure for the Russia-Ukraine Conflict

Embedded Systems

The Russia-Ukraine conflict has revealed that fiber-optic controlled UAVs can bypass conventional detection systems. Radar fails against low-altitude targets with small radar cross-sections;…

A Novel Mantis-Shrimp-Based Smart Glove for Stroke Rehabilitation

This research discusses the design and development of a mantis -shrimp-inspired smart glove targeted at aiding stroke therapy. The glove combines soft and rigid materials in a hybrid exoskel…

A Novel Method for Cancer Whole Slide Image Processing Utilizing a Multi-Scale Convolutional Residual Neural Network for Regression

Translational Medical Science

Cancer remains a leading cause of death worldwide, with approximately 10 million fatalities annually. Whole Slide Imaging (WSI) and Deep Learning can enhance histopathological analysis, enab…

A Novel Method of Predicting Ocean pCO2 Using a Polynomial Model

Earth and Environmental Sciences

Understanding pCO2 is essential for assessing the ocean's role in the global carbon cycle. However, in many current methods for predicting pCO2, satellite-derived measurements for regional w…

A Novel Method of Water Purification: Optimizing Foam Fractionation for Effective Broad- Spectrum Removal of DBP and DBP Precursors in Chlorinated Drinking Water

University In the 20th century, water treatment plants began using disinfectants like chlorine to eliminate waterborne diseases such as cholera and typhoid. However, this process results in…

A Novel Method of Water Purification: Optimizing Foam Fractionation for Effective Broad-Spectrum Removal of DBP Precursors in Chlorinated Drinking Water

Earth and Environmental Sciences

Water treatment plants use disinfectants like chlorine to eliminate waterborne diseases such as cholera and typhoid. However, disinfection results in the formation of disinfection byproducts…

A Novel Method to Analyze Thermonuclear Explosions in Four Binary Star Systems Using NASA’s High Time Resolution TESS Data

Novae eruptions occur in interacting binary star systems when a white dwarf is accreting mass from its companion. When the shell of material reaches the flash point, a runaway thermonuclear…

A Novel Method to Optimize CAR T-Cell Therapy by Targeting CD25+ T-Cell Malignancies Through Bispecific Aptamer-Mediated ScFv Engagement

Computational Biology and Bioinformatics

T-cell malignancies contribute significantly to the high mortality rates of lung and colon cancers, two of the deadliest globally. Current CAR T-cell therapies, while promising, suffer from…

A Novel Morphing Nose Cone Mechanism for Aerodynamic Optimization of a Supersonic Airplane

Engineering Technology: Statics & Dynamics

The aerodynamic efficiency of an aircraft's nose cone is crucial to overall flight performance. Traditional nose cone designs are optimized for specific speed regimes, which limits their ove…

A Novel Multi-Modal Deep Learning Approach With Attention Mechanisms for Early Detection of Alzheimer's Disease

Translational Medical Science

Alzheimer's disease (AD) remains difficult to diagnose in its early stages. Current diagnostic approaches often miss subtle early symptoms, delaying intervention. In this research, a novel m…

A Novel Spintronics-based Circulating Tumor Cell Biosensor for Early Metastasis Detection

Biomedical Engineering

Cancer spreads throughout the body in a process named metastasis. Circulating tumor cells (CTCs) play a critical role in promoting metastatic cancers, which cause approximately 90% of cancer…

A Novel Study in the Utilization of Artificial Intelligence, Machine Learning, and Convolutional Neural Networks in the Identification of Differing Recyclable Materials

Robotics and Intelligent Machines

Due to growing industries and poor methods of recycling, landfills are filled with millions of tons of wasted recyclable materials. Making recycling more accessible to communities around the…

A Novel Synergistic Approach: Combining AMOX Antibiotic or Kigelia Extracts With AgZn NPs as a Potent and Efficient Strategy to Combat Antibiotic-resistant Bacteria

Biochemistry

Antibiotic drug resistance causes an estimated 1 million deaths each year and over 200 trillion USD in healthcare costs. Amoxicillin (AMOX) is an antibiotic effective against a broad range o…

A Novel Theory-Driven Approach for Model Compression in Deep Neural Networks

Mathematics

In this study, I present a novel approach for model compression to reduce the size of neural network models. In recent years, with the rise of LLMs such as ChatGPT, deep learning models have…

A Novel Treatment Approach to Mitigate Adverse Cardiovascular Effects of Burn Pit Exposure

Biomedical and Health Sciences

Anthropogenic open burning is known to release hazardous chemicals and has been associated with an increased prevalence of cardiopulmonary issues. For example, studies show that veterans who…

A Novel Treatment of Obstructive Sleep Apnea Using Continuous Wave Interferometry Radar

Embedded Systems

In recent years, radar technology has gained significant interest in its application in detecting vital signs. It has the potential to play a crucial role in identifying obstructive sleep ap…

A Novel Union-Find-Based Decoding Algorithm for Scalable Real-Time Syndrome Processing in Quantum Error Correction

Systems Software

Fault tolerant quantum computing (FTQC) provides huge promises for industrial and scientific progress, such as in drug discovery and cryptography. Part of the technology stack required for F…

A Novel Wireless Charging System for IMDs Using 2.4GHz EM Waves

Energy: Sustainable Materials and Design

Thirty-five million Americans have an implanted medical device (IMD), like a pacemaker. IMDs have a fixed battery life (~7-12 years), requiring invasive surgery to replace the battery, with…

Anthocyanin in Zooxanthellae

Earth and Environmental Sciences

Zooxanthellae is the mutualistic microorganism that lives in coral and provides nutrients for the expansion of coral with the byproducts of photosynthesis. The main photosynthetic pigment is…

Antimicrobial Effect of Copper Alloys on E. coli, S. enterica, and S. aureus

Microbiology

The oligodynamic effect is the ability of metals to kill microbes, including bacteria. This effect is vital to modern methods of sterilization, as biocidal metals are commonly incorporated i…

Antimicrobial Potential of the Hydroalcoholic Extract of Myracrodruon urundeuva (Aroeira)

Translational Medical Science

Hospital infection is a serious current problem, affecting patients and generating high costs for public healthcare. One solution would be sustainable and natural alternatives. In this way,…

Anti- Plaque Toothpastes Effect on Plaque Growth

Biomedical and Health Sciences

This study aimed to evaluate the effectiveness of various anti-plaque toothpaste formulations in reducing plaque, with a particular focus on comparing whitening and non-whitening products. P…

Ant It Sweet? Analyzing the Effects of Aspartame, Sucralose, Acesulfame K, and Saccharin on the Feeding, Mortality, and Gut Microbiota of Camponotus floridanus

Biomedical and Health Sciences

Globally, over 18% of men and 20% of women have been diagnosed with obesity as of 2025. While approved artificial sweeteners like aspartame, sucralose, acesulfame K, and saccharin are common…