Search past science fair projects

Novel Approach to Creating Hyper-Customizable Egg Models for Embryonic Analysis

Biomedical Engineering First Award

This research aimed to enhance the accessibility and customizability of domestic chicken eggs for embryonic analyses and model system research. Through the engineering of a novel device, a s…

Novel Function of Paxillin in Modulating RNA Splicing During Early Neuron Development

Cellular and Molecular Biology

Paxillin is a known regulator of focal adhesions and actin cytoskeleton dynamics, crucial for cell migration. However, our study discovered a novel function of paxillin in neurons. We found…

Novel Imaging Approaches for the Quantification of Changes in Perivascular Space Volume and Morphology in Response to Transcranial Direct Current Stimulation

Cellular and Molecular Biology

Purpose: Though the behavioral effects of transcranial direct current stimulation (tDCS) are well-documented, a gap exists in current literature on its effects on glymphatic system dynamics…

Novel Imaging Approaches for the Quantification of Changes in Perivascular Space Volume and Morphology in Response to Transcranial Direct Current Stimulation

Medical School, Boston, MA Purpose: Though behavioral effects of transcranial direct current stimulation (tDCS) are well-documented, a gap exists in current literature on its effects on glym…

Novel Isolation and Filamentation of Drosophila melanogaster Phosphofructokinase-1

Cellular and Molecular Biology

This study aimed to determine if Drosophila melanogaster PFK (DmPFK) forms filaments, and if so, under what conditions. Enzyme filamentation, or the reversible formation of oligomers, has be…

Novel Machine Learning Software for DeNoising and Visualizing EEG Data

Computational Biology and Bioinformatics

EEGs are an important tool used by clinicians to diagnose neurological abnormalities such as epilepsy, and by medical researchers to map the functions of different components of the brain. H…

Novel Multivariate Analysis of Road Erosion Factors Through the Utilization of Structural Equation Modeling (SEM) to Model Road Erosion Risk

Earth and Environmental Sciences

With the impacts of climate change intensifying, sea level is expected to rise 0.25–0.30 meters by 2050. With a one-degree Celsius rise in temperature, precipitation globally is expected to…

Novel Oral Treatments Infused With Native Plant Extracts to Improve Oral Health in Developing Countries

Microbiology

Oral diseases such as tooth decay are expected to affect 3.5 billion individuals worldwide. In most developing countries, access to primary oral health treatments is limited due to an unequa…

Novel Organ Preservation Approaches Enhance Hepatocyte Survival for Liver Transplantation

Liver transplantation is the most effective therapy for patients with end-stage liver disease. The process of liver transplantation involves the removal of the liver from a brain-dead donor…

Novel Pharmacogenomic Methodology for the Discovery of First-In-Class Mechanisms of Phenothiazine Derivatives to Delay and Rescue Alzheimer’s Disease Pathology and Extend Lifespan in C. elegans

Biomedical and Health Sciences

Alzheimer’s Disease (AD) is the most common neurodegenerative disorder and the leading cause of death in the US. There are currently no effective drugs for this disease due to lack of unders…

Novel Piezoelectric Nanogenerator for Biomedical Applications

Materials Science

Every year, millions of people incur damage to sensory receptors that interact with the external environment. Two areas of concern are hearing loss (affecting around 700 million by 2050) and…

Novel Prenatal ASD Diagnosis Tool

Behavioral and Social Sciences

Autism spectrum disorder (ASD) is a heterogeneous category of impairments characterized by repetitive behaviors and impaired social communication which is currently diagnosed behaviorally. I…

Novel Probiotic Treatment for Candida albicans Utilizing Antifungal Inhibitors of Lactobacillus acidophilus via a Bombyx mori Infection Model

Candidiasis refers to various infections attributable to the opportunistic yeast fungus Candida. These infections possess the ability to manifest in various forms specific to the location of…

Novel Red Blood Cell Membrane-Wrapped Septenary High-Entropy-Alloy Nanoparticles for Photothermal Osteosarcoma Treatment, Year 2

Chemistry

As the field of cancer research increases, photothermal nanoparticles have become a forefront for localized cancer treatment. High-entropy-alloy nanoparticles, consisting of at least 5 alloy…

Novel Small Scale Carbon Dioxide Capture Polymer Membrane for Sudden Infant Death Syndrome Prevention

Materials Science

Sudden Infant Death Syndrome (SIDS) is a leading cause of infant death, causing 41% of sudden unexpected infant death nationwide. SIDS is attributed to (i) rebreathing CO2 and (ii) inorganic…

Novel Stacked Ensemble Machine Learning (SEML) Model for Prediction of Viral Zoonoses

75% of newly emerging infectious diseases, including Ebola and Rabies, are zoonotic. Originating from animals, zoonotic diseases comprise over 2 billion cases of illness and 2.7 million deat…

Novel Strategies for the Reversal of Cancer Cell Immortality

Biomedical and Health Sciences Second Award

Glioblastoma (GBM) is the most common malignant adult brain tumor. With minimal clinical innovation, the prognosis for GBM patients remains grim. However, there is a commonality between 83%…

Novel Therapeutic Efficacy of Curcumin and Fish Oil (Omega-3 Fatty Acids) on Inhibiting Neuroinflammation and Neuronal Apoptosis in Mus musculus Microglial Cells

Translational Medical Science Fourth Award

Neurological disorders, such as Parkinson’s Disease and Alzheimer's Disease, have become more common in recent years, with the number of deaths due to neurological disorders increasing by ab…

Novel Wearable Volatile Organic Compound Detection and Mitigation via Cumulative Solvatochromism and Dietary Modification

Environmental Engineering First Award

1.1 billion individuals worldwide, particularly low-income workers in remote settings, are unknowingly exposed to dangerous gaseous concentrations of Volatile Organic Compounds (VOCs), accor…

NueROX: A Visual Diagnosing System Using a Fully Optimized Convolutional Neural Network Architecture for Rapid and Efficient Classification of Tumorous and Non-Tumorous Brain MRI's and a Model for the Segmentation, Dimension, and Severity Estimation of Brain Tumors

Translational Medical Science

Brain tumors are a significant and growing health concern in the United States, with an estimated 700,000 people living with a primary brain tumor. Misdiagnosis is a major issue with brain t…

Object Recognition with Contextual Reasoning Based Fuzzy Neural Networks for the Uncertainty Output

Object recognition is an important task in image processing and fuzzy neural network (FNN) is a popular tool for object recognition. However, when applied to datasets that present complex an…

Object Recognition With Contextual Reasoning Based Fuzzy Neural Networks for the Uncertainty Output

Robotics and Intelligent Machines Fourth Award

Object recognition is an important task in image processing and a fuzzy neural network (FNN) is a popular tool for object recognition. However, when applied to datasets that present complex…

Observing the Benefits of the Involvement of Pressure in the Annealing of 3D Printed Components for Higher-Strength Applications

Materials Science

The goal of this study was to determine if the annealing process of 3D printed polymers could be further enhanced with the addition of constant pressure during the procedure. The purpose is…

Occupational Stress and Mental Health Outcomes Among the Emergency Medical Services Population

Behavioral and Social Sciences

Emergency Medical Service (EMS) providers experience high levels of occupational stress due to long hours, short staffing, and patient deaths, among other factors. Little is known about the…

OctoGrasp: The Design and Construction of a Cephalopod-Inspired Prosthetic Arm

Biomedical Engineering Second Award

Purpose The purpose of the OctoGrasp project is to design and build a highly dexterous bio-mimetic prosthetic arm inspired by the biology of cephalopods. Typical prosthetics rely on force at…

O.D.O.B.A

Environmental Engineering

The goal is to determine if the scientist could create an easily accessible database of sea turtle blood images and an open-sourced machine learning algorithm that partners with a developing…

On a New Variant of Prime Factorization Algorithm

Mathematics

For centuries, prime factorization has been a fundamental theoretical problem in the mathematical world. Conventionally, the algorithms for prime number factorization demand a computational…

OncoPharML: A Machine-Learning Approach for Cancer Biomarkers Identification and Multi-Omics-Based Targeted Cancer Drug Prediction

Translational Medical Science

The current practice of treating cancer with radiation, chemotherapy, and immunotherapy is a one-size-fits-all approach in which patients with the same type and stage of cancer receive the s…

OncoRx: An Integrative Approach to Identification of Pan-Cancer Molecular Biomarkers and Prediction of Targeted Multi-Drug Cancer Therapeutics

The current practice of treating cancer with radiation, chemotherapy, and immunotherapy is a one-size-fits- all approach, where patients with the same type and stage of cancer receive the sa…

On Enumeration of Semigroup Ideals

Mathematics

Computing the Frobenius number for numerical semigroups with more than three generators is a famous unsolved problem in number theory and computational complexity. Given a numerical semigrou…