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Identifying a Novel Gene Signature to Predict Drug Resistance in Epilepsy Patients

Computational Biology and Bioinformatics

One in twenty-six people worldwide develops epilepsy during their lifetime, including myself. Around 30% of epilepsy patients are nonresponsive to medication. It is important to identify the…

Identifying, Cloning, and Validating a Lysin Gene Into E. coli

Microbiology

Candidatus Liberibacter asiaticus (Clas), the causative agent of Citrus Greening disease, has ravaged Florida's citrus industry. Because Clas is unculturable, Sinorhizobium meliloti, a close…

Identifying Novel Drugs to Inhibit APOE4 as a Therapeutic Intervention for Treating Alzheimer's

Translational Medical Science Fourth Award

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that impacts memory by destroying the neurons of the brain cells. AD is characterized by the presence of two types of prot…

Identifying Novel miRNA Targets and Therapeutics Through A Network-Based Computational Pipeline

Computational Biology and Bioinformatics

miRNAs are small, non-coding RNAs significant in numerous biological processes and disease pathways, proven heavily dysregulated in cancers, with prior literature revealing their potential a…

Identifying Novel Modes of Inhibition of C. pusillum and B. subtilis Bacteria, Against Deadly Bat Fungus, Pseudogymnoascus destructans (Year 8)

Microbiology Second Award

Bats, like bees, are a keystone species benefiting the environment and saving farmers billions of dollars in chemicals. However, since 2006, millions of bats in North America have died of a…

Identifying Relationships Between the Gut Microbiome and Melanoma Patients' Responses to Immunotherapy Using Machine Learning Techniques

Translational Medical Science

Melanoma is a rapidly metastasizing deadly cancer making it crucial to find the most effective treatment immediately. This year in the US, it is expected to be diagnosed in 97,610 patients a…

Identifying the Common Functions of Genes Linked to Autism Spectrum Disorder (ASD)

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a significant genetic contribution. Studies have identified hundreds of genes with evidence of involvement in ASD when mu…

Identifying the Molecular Mechanisms of a Safer Neuroblastoma Cure Using the Native Hawaiian 'Awapuhi (Zingiber zerumbet) Herb

Translational Medical Science Fourth Award

Neuroblastoma is one of the most severe tumors in young children with nearly 500 new cases reported each year. Currently, the only treatments available for this cancer are chemotherapy and r…

Identifying the Molecular Mechanisms of a Safer Neuroblastoma Cure Using the Native Hawaiian ʻAwapuhi (Zingiber zerumbet) Herb

Neuroblastoma one of the most severe tumors in young children with nearly 500 new cases reported each year. Currently, the only treatments available for this cancer are chemotherapy and radi…

I-Krobs: Robot That Dispenses Oral Sodium Iodine i-131 Radiotherapy Capsules for Patients With Thyroid Diseases

Robotics and Intelligent Machines

In the field of medicine, healthcare workers are regularly exposed to radiation over extended periods of time, which lead to various health problems. Although numerous regulations and guidel…

ILLINOIS-CHICAGO Predicting Large Wildfires Using Machine Learning Approach towards Environmental Justice via Remote Sensing

Wildfires pose severe health and ecological consequences. In 2021 alone, 58,968 wildfires burned 7.1 million acres across the United States. Large wildfires (> 300 acres) in the United State…

Immune Checkpoint Regulation in Molecular Subtypes of Endometrial Cancer: Expression of PD-L1 and PD-1

Biomedical and Health Sciences

Endometrial cancer is the 4th commonest cancer in women. The current treatment options show inconsistent results. There is a newer treatment option called targeted therapy. One example uses…

Impact of Biochar as Soil Amendment on Produce Yield (Year 1)

Plant Sciences

Conventional agricultural practices have resulted in infertile soils, excessive use of pesticides, nutrient run-offs, reduced microbial activities and depleted water resources for soil culti…

Impact of Methylene Blue Dye on Response of Solanum lycopersicum to Stress Caused by High Salinity

Plant Sciences

This project investigated the difference in growth of tomato plants experiencing saline stress when injected with methylene blue dye. The procedures followed were similar to those outlined b…

Impact of Social/Traditional Media on Political Polarization

There is a common perception that political polarization is increasing in American society and the blame is often assigned to highly partisan traditional media (e.g., TV news channels) and t…

Impacts of Levodopa and Traditional Medicines on the Locomotion of Alpha-Synuclein Caenorhabditis elegans

Behavioral and Social Sciences Fourth Award

Parkinson’s Disease is a slowly progressive neurodegenerative disorder caused by the death of dopamine-producing neurons. Due to a decrease in dopamine, patients suffer from both motor and n…

Impacts of Ocean Acidification and Elevated Temperatures on Acusta Assimilis

Ocean acidification and elevated temperatures are rising issues as they lead to substantial changes in the ocean’s chemistry and have adverse effects on the ecosystem of oceanic organisms. T…

Implementation of Land Cover Data to Forecast West Nile Virus in the United States

Computational Biology and Bioinformatics Fourth Award

West Nile virus (WNV) is the most impactful mosquito-borne disease in the United States. Since 1999, it has caused over 2,500 deaths and has seriously harmed quality of life for thousands of…

Implementing a Hybrid Quantum-Classical Neural Network by Utilizing a Variational Quantum Circuit for Detection of Dementia

Physics and Astronomy

Magnetic resonance imaging (MRI) is a common technique to scan brains for strokes, tumors, and other abnormalities that cause forms of dementia. However, correctly diagnosing forms of dement…

Implementing A Hyper-Realistic Physics Engine in The Unity 3D Gaming Software in a Virtual-Reality Based Prosthetic Training & Baseline Tests

Despite nearly 2 million people in the United States having an upper-arm amputation, 27- 56% of upper-body amputees use a prosthetic arm to regain limited mobility of their arm pre-amputatio…

Implementing Nontoxic Modified Biochar Enhanced Filtration for the Efficient Removal of Emerging Contaminants in an Aqueous Solution

Many water sources contain emerging contaminants that currently lack sufficient regulation but lead to debilitating health and environmental effects, yet current standard water treatment pro…

Implementing Quantum-Classical Machine Learning Architectures to Optimize Convolutional Neural Networks

Larger sets of data and information in computational systems are oftentimes misinterpreted or tedious to analyze because of human error. Classical machine learning (ML) can be sufficient in…

Improved Generalizability and Performance on Small Datasets Using Hyper-Connected Neural Architectures, C. elegans-Inspired Networks, and Evolutionary Modeling

Computational Biology and Bioinformatics Second Award

Neural networks are fundamentally flawed. In even the most trivial tasks like digit recognition, they require tens of thousands of training examples to achieve near-human accuracy. In contra…

Improved System for Hazardous Gas and Heat Detection and an Alert System for Households

Embedded Systems

With many fires happening daily in communities and homes the need for inexpensive, reliable, saleable warning systems, more than just a simple audible fire alarm that is currently used, is h…

Improvements on Schlieren Imaging

Physics and Astronomy

Schlieren imaging is used to show gradients in the temperature and density of air, water, and other materials. It does so by sending light through the test area and filtering out the light t…

Improvements to the Design of Bridges for Resilience During Atmospheric Events in Puerto Rico

Engineering Technology: Statics & Dynamics

Several public roads and bridges across the world provide travel between locations. In Puerto Rico they are mainly impacted by atmospheric events that impact the region in certain season. Du…

Improving Aquilaria crassna callus Sesquiterpenoid Production Using MOFs

Plant Sciences Fourth Award

Specialty metabolites used in food, medicine, pesticides, and fragrances are valuable in virtue of their unique properties, but they face challenges in production due to high costs associate…

Improving Bitcoin's Post-Quantum Transaction Efficiency with a Novel Lattice-Based Aggregate Signature Scheme Based on CRYSTALS-Dilithium and a STARK Protocol

Quantum computing is revolutionizing cryptography, but it will render the classical digital signature schemes such as ECDSA (Elliptic Curve Digital Signature Algorithm) insecure. Therefore,…

Improving Bitcoin's Post-Quantum Transaction Efficiency With a Novel Lattice-Based Aggregate Signature Scheme Based on CRYSTALS-Dilithium and a STARK Protocol

Mathematics Third Award

Quantum computing is revolutionizing cryptography, as it will render the classical digital signature schemes such as Bitcoin's ECDSA (Elliptic Curve Digital Signature Algorithm) insecure. Th…

Improving Contemporary Mathematical Models of Metastatic Cancer to Predict Optimal Treatment: Analyzing Glycolysis, Treatment, and PACC Quiescence

Mathematics

Pancreatic metastatic cancer prompts the aggressive emergence of a subsect of cancer cells known as Poly-aneuploid Cancer Cells (PACCs) which sustain a state of dormancy called quiescence wh…